STUDY ON MULTIPOTENT MEDICINAL ASPECTS OF SCHIMA WALLICHII (BARK) FROM NAGALAND, NE INDIA
DOI:
https://doi.org/10.22159/ajpcr.2019.v12i3.29288Keywords:
Schima wallichii, Antioxidants, 2,2-diphenyl-1-picrylhydrazylhydrate, Phytochemicals, Anticoagulase, AntimicrobialAbstract
Objective: The present study focuses on the multipotent medicinal aspects of Schima wallichii bark.
Methods: The ethanol and water extracts of the plant were investigated its phytochemical, antibacterial, antioxidant, and anticoagulant as per the standard method.
Results: S. wallichii bark extract was effective against Staphylococcus aureus. It was also found to be a good antioxidant having an IC50 value of 98.7 in ethanolic extract. Further, the water extract increased in prothrombin time to 57.7 s against normal (12.3 s). The different phytochemicals, namely tannin, saponins, steroids, terpenoids, flavonoids, and glycosides, were present. Since the findings showed very less percent inhibition in comparison to curcumin-treated cells, thus both the extracts were both not effective in the antiproliferative assay.
Conclusion: We conclude that this plant is a good candidate for developing a natural drug.
Downloads
References
Available from: http://www.kerenvis.nic.in/Database/Hotspot_1804.aspx. [Last accessed on 2018 Jun 26].
Shimray UA. Naga Population and Integration Movement. New Delhi: Mittal Publications; 2007. p. 25-33.
Cragg GM, Newman DJ. Natural products: A continuing source of novel drug leads. Biochim Biophys Acta 2013;1830:3670-95.
Saranya TK, Gowrie SU. Phytochemical analysis and in vitro studies on antibacterial, antioxidant and anti-inflammatory activities using Casuarina equisetifolia bark extracts. Int J Pharm Pharm Sci 2017;10:118-25.
Bair S, Remakanthan A, Kumar HH, Aryakrishna UK. Comparative study of the phytochemicals, antioxidant and antibacterial potential of methanolic extracts of Trichosanthes cucumerina (l) Var Cucumerina under in vitro culture and natural conditions. Int J Pharm Pharm Sci 2017;10:147-54.
Min T, Bartholomew B. Schima wallichi Missouri Botanical Garden, Flora of China. St Louis MO. China, Cambridge, MA: Harvard University Herbaria; 2014.
Trease G, Evans SM. Pharmacognosy. 15th ed. London: Bailer Tindal; 2002. p. 23-67.
Harbourne JB. Phytochemical methods a Guide to Modern Techniques of Plant Analysis. 2nd ed. London: Chapman and Hall; 1984. p. 4-16.
Kaur S, Mondal P. Study of total phenolic and flavonoid content, antioxidant activity and antimicrobial properties of medicinal plants. J Microbiol Exp 2014;1:23-8.
Bauer AW, Kirby WM, Sherris JC, Turck M. Antibiotic susceptibility testing by a standardized single disk method. Am J Clin Pathol 1966;45:493-6.
Miale JB. The fibrometer system for routine coagulation tests: Prothrombin time and partial thromboplastin time, macro and micro. Am J Clin Pathol 1965;43:475-80.
Berridge MV, Herst PM, Tan AS. Tetrazolium dyes as tools in cell biology: New insights into their cellular reduction. Biotechnol Annu Rev 2005;11:127-52.
Lalrinzuali K, Vabeiryureilai M, Chandra G. Ethnomedicinal use and phytochemical analysis of selected medicinal plants of Mizoram India. Trends Green Chem 2015;1:1-9.
Available from: https://www medlineplus.gov.bloodthinners.html. [Last accessed on 2018 Jun 26].
Saikat D, Anup M, Rupa M, Avijit M, Subhash MC. Evaluation of antimicrobial activity of hydroalcoholic extract Schima wallichii bark. Pharmacology 2008;1:523-8.
Shantabi L, Jagetia GC, Vabeiryureilai M, Lalrinzuali K. Phytochemical screening of certain medicinal plants of Mizoram, India and their folklore use. J Bio Biopros Dev 2014;1:136.
Lalhminghlui K, Chandra JG. Evaluation of the anticancer activity of chilauni, Schima wallichii (DC.) Korth. In vitro. Int Res J Pharm Biosci 2017;2017:30-51.
Published
How to Cite
Issue
Section
The publication is licensed under CC By and is open access. Copyright is with author and allowed to retain publishing rights without restrictions.
