Objective : Eclipta alba (Asteraceae) is a traditional medicinal plant known as Bhringaraj.This plant  has been used for the treatment of a variety of diseases. The leaves of Eclipta alba showed antihyperglycemic activity. The roots of Eclipta alba were found effective in wound healing .

Methods : This study was undertaken to evaluate the possible antidepressant effect of  Eclipta alba leaf extract (EALE)  using Tail suspension test(TST) & Forced swim test (FST).  36 albino rats of either sex weighing between 20-25gm were randomly selected divided into 6 equal groups.  Group-I (control) received polyethyleneglycol (1ml/100gm),Group-II, III & IV received EALE in doses of 100,200,400 mg/kg orally (P.O.) respectively. Group V & VI (positive control) received Fluoxetine & Imipramine at doses of 20mg/kg & 15mg/kg p.o respectively.  Drug treatment was given for seven & fourteen successive days.  60 minutes after last dose of drug or standard the immobility period was recorded.

Results : EALE produced significant antidepressant like effect at dose of 200 & 400 mg/kg administered for 7 & 14 consecutive days as indicated by reduction in immobility times of mice in TST & FST (P<0.05). The efficacy of EALE at 200mg/kg was found to be comparable to that of Fluoxetine & Imipramine at doses of 20mg/kg & 15mg/kg. Conclusion: The results of the present study indicate that EALE possesses significant antidepressant activity compared to that of both Fluoxetine & Imipramine.


Eclipta alba , Forced swim test, Tail suspension test, Antidepressants, Immobolity time


Chopra RN, Nayar SL, Chopra IC. Glossary of Indian Medicinal Plants. Council of Scientific and Industrial Research, New Delhi, India 1956.

Gold PW, Goodwin FK. Clinical manifestations of depression in relation to neurobiology of stress: N Engl j Med 1988;319; 348-353.

Zhang ZJ. Therapeutic effects of herbal extracts and constituents in animal models of psychiatric disorders. Life Science 2004; 75: 1659–99.

Mehra P N, Nanda S S: Pharmacognosy of Bhringaraja. Antihepatotoxic drug of Indian origin. Ind. J. Pharm, 1968; 30: 284.

Chandra T, Sadique J and Soma Sundram S: Effect of Eclipta alba on inflammation and liver injury. Fitoterapia, 1987; 58(1): 23-32.

Wagner H, Geyer B, Yoshinobu K et al. Coumestans as the main active principles of the liver drugs Eclipta alba and Wedelia calendula. Planta Med 1986;52:370-4.[Pubmed]

Reddy KRK, Tehara SS, Goud PV et al. Comparison of anti-inflammatory activity of Eclipta alba and Solanum nigrum (mako Kushk) in rats. J Res Edu Indian Med1990;9:43-6.

Lin SC, Yao CJ, Lin CC et al. Hepatoprotective activity of Taiwan folk medicine: Eclipta prostrata Linn. Against various hepatotoxin induced acute hepatotoxicity. Phytother Res1996;10:483-90.

Puri HS. Rasayana: Ayurvedic Herbs for longevity and rejuvenation. London, Taylor&Francis,2003.

Porsolt RD, Bertin. A, Behaviour despair in mice: A primary screening test for antidepressants .Archives Internationales de Pharmacodynamie et de therapie 1977;229:327-36

Steru. L, Chemat. R, The tail suspension test: A novel method for screening antidepressants in mice. Psychopharmacology 1985;85:367-70

Vikas gupta, P.bansal, P.kumar, R.shri:Anxiolytic and antidepressant activities of different extracts from Citrus paradisi var. Duncan Asian journal of pharmaceutical &clinical research :Vol.3 Issue 2, Aprilâ€June 2010

D. Dhingra, A. Sharma et al. Alt &complementary therapies,Feb2005(51-52)

M. Jesupillai, S. Jasemine, M. Palanivelu. Diuretic activity of leaves of Erythrina indica Lam. International Journal of Green Pharmacy. October-December 2008:218.



How to Cite

SWATI, M., J. MONALISA, and P. ABHISEK. “EVALUATION OF ANTIDEPRESSANT ACTIVITY OF ECLIPTA ALBA USING ANIMAL MODELS”. Asian Journal of Pharmaceutical and Clinical Research, vol. 6, no. 7, Aug. 2013, pp. 118-20, https://innovareacademics.in/journals/index.php/ajpcr/article/view/295.