PREPARATION OF MUCOADHESIVE GASTRORETENTIVE DRUG DELIVERY SYSTEM OF ALGINATE BEADS CONTAINING TURMERIC EXTRACT AND ANTI-GASTRIC ULCER ACTIVITY

Authors

  • Hakim Bangun Department of Pharmaceutical Technology, Faculty of Pharmacy, Nanomedicine Centre of Innovation, University of Sumatera Utara, Medan, Indonesia.
  • Fadlina Aulia Department of Pharmaceutical Technology, Faculty of Pharmacy, Nanomedicine Centre of Innovation, University of Sumatera Utara, Medan, Indonesia.
  • Anayanti Arianto Department of Pharmaceutical Technology, Faculty of Pharmacy, Nanomedicine Centre of Innovation, University of Sumatera Utara, Medan, Indonesia.
  • Marline Nainggolan Department of Pharmaceutical Biology, Faculty of Pharmacy, University of Sumatera Utara, Medan, Indonesia.

DOI:

https://doi.org/10.22159/ajpcr.2019.v12i1.29715

Keywords:

Turmeric extract, Alginate beads, Mucoadhesive, Gastroretentive, Anti-gastric ulcer

Abstract

Objectives: The objectives of this study were to prepare the mucoadhesive mucoadhesive gastroretentive drug delivery system of alginate beads containing turmeric extract and to evaluate its anti-gastric effect.

Methods: Turmeric extract was made by macerating turmeric powder in ethanol 96% and evaporated using rotary evaporator at 50°C to obtained concentrated extract. Then, it was prepared alginate beads containing 5% turmeric extract by gelation method. The mucoadhesive properties of alginate beads containing turmeric extract were tested in vitro in male rats and the anti-gastric ulcer effect was tested on HCl-induced gastric ulcer in rats.

Results: The mean diameter of alginate beads obtained was 1.13±0.19 mm. Bioadhesion test showed that alginate beads containing turmeric extract could be attached on gastric rats mucosa. Anti-gastric ulcer test showed that the healing of gastric lesions in rats was faster using alginate beads containing turmeric extract compared to untreated ones.

Conclusions: The results of this study suggest that mucoadhesive drug delivery systems of alginate beads containing turmeric extract are potentially developed as an anti-gastric ulcer.

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Published

07-01-2019

How to Cite

Bangun, H., F. Aulia, A. Arianto, and M. Nainggolan. “PREPARATION OF MUCOADHESIVE GASTRORETENTIVE DRUG DELIVERY SYSTEM OF ALGINATE BEADS CONTAINING TURMERIC EXTRACT AND ANTI-GASTRIC ULCER ACTIVITY”. Asian Journal of Pharmaceutical and Clinical Research, vol. 12, no. 1, Jan. 2019, pp. 316-20, doi:10.22159/ajpcr.2019.v12i1.29715.

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