FORMULATION AND EVALUATION OF BILAYERMATRIX TABLET OF PIOGLITAZONE HCL METFORMIN HCL USP 15MG&500MG

  • KOTTA KRANTHI KUMAR
  • M. Narasimha reddy
  • R.NAGA KISHORE

Abstract

ABSTRACT

The aim of present study was to design the concept of bilayered tablets containing Pioglitazone hydrochloride for immediate release using cross Povidone as super disintegrant and Metformin hydrochloride for sustained release using poly ethylene oxide (PEO-303) as matrix forming polymer. The tablets were evaluated for physicochemical properties. All the values are found to be satisfactory. In vitro release studies were carried out as per USP in pH 1.2 and phosphate buffer pH 6.8 using the USP apparatus II. The release kinetics of Metformin hydrochloride was evaluated using the regression coefficient analysis. The formulated tablets (F5) shows first order release and diffusion was the dominant mechanism of drug release. The polymer Polyethylene oxide (PEO- 303) had significant effect on the release of Metformin HCl matrix tablets (F5).Thus formulated bilayer tablets proved immediate release of Pioglitazone and Metformin HCl as sustained release over a period of 12 hours. The stability studies and FT-IR studies were also indicating the absence of strong interactions between the components and suggesting drug-excipient compatibility in all the formulations examined.

Keywords: Bilayered tablets, Sustained release, Metformin HCl, Pioglitazone HCl, Matrix tablets, PEO-303.

References

1. Lechman, L., Liberman, H.A., Kanig, J.L.,In., The Theory and Practice of Pharmacy, 3rd Ed., Varghese Publishing House,Bombay, 1987, p 430-453.
2. Notari, R., Biopharmaceutics and Clinical Pharmacokinetics, An Introduction, 3rd Ed., Marcel Dekker Inc. New York, 1980, p152-54.
3. Dr P.K. Sahoo.Pharmaceutical technology,Delhi Institute of Pharmaceutical Sciences and research. New Delhi:Page no 1-3.
4. Remington,The Science and Practicen of pharmacy”, 20th Edition, Volume I, Pg.No.903-913.
5. Raymand C Rowe, Paul J Sheskey, Paul J Weller, Handbook of Pharmaceutical Excipients”, 4th edition, publish by Pharmaceutical Press, 297-300.
6. Brahmankar D.M. and Jaiswa S.B.inBiopharmaceutics and Pharmacokinetics”, "A Treatise,” Vallabh Prakashan, 1st Edition, 1995, Pg.No.347- 3
7. Raymand C Rowe, Paul J Sheskey, Paul J Weller, Handbook of Pharmaceutical Excipients”, 4th edition, publish by Pharmaceutical Press, 297-300.
8. Mr. ashish a pahade, dr. mrs. v.m.jadhav and dr. mr. v.j.kadam, Formulation and development of a bilayer sustained released tablets of isosorbide mononitrate” international journal of pharma and bio sciencesvol.1/issue-4/oct-dec.2010.
9. Chinam niranjan patra, Arethi bharani kumar, Hemant kumar pandit, Satya prakash singh Meduri vimala devi, Design and evaluation of sustained release bilayer tablets of propranolol hydrochloride”, Acta Pharm., 2007; 479–489.
10. Chitra karthikeyini.S, Jayaprakash.S, Abirami.A, Mohamed Halith.S, Formulation and Evaluation of Aceclofenac sodium Bilayer sustained release tablets”, International Journal of ChemTech Research, Oct-Dec 2009; vol-1, No.4, 1381-1385.
11. Madhusudan Rao Yamsani et; al, Factors Influencing the Design and Performance of Oral Sustained/Controlled Release Dosage Forms”, International Journal of Pharmaceutical Sciences and Nanotechnology, vol-2, Issue-3, October- December 2009; 583-593.
12. Patel D, Patel A, Solanki T. Formulation and evaluation of bilayer tablet by using melt granulation technique for treatment of diabetes mellitus. J Pharm Bioallied Sci. 2012 Mar;4(Suppl 1):S37-9. doi: 10.4103/0975-7406.94135.
13. Mandal U, Gowda V, Ghosh A, Selvan S, Solomon S, Pal TK. Formulation and optimization of sustained release matrix tablet of metformin HCl 500 mg using response surface methodology.
Yakugaku Zasshi. 2007 Aug;127(8):1281-90.
14. Shahi, SaAdhaana; Shivanikar, Shantanu; Zadbuke et al Formulation and evaluation of Bilayer Tablet of Metformin Hcl and Pioglitozone Hcl International Journal of Pharmacy & Pharmaceutical Sciences;Dec2012 Supplement 5, Vol. 4, p380.
15. Patra CN, Kumar AB, Pandit HK, Singh SP, Devi MV. Design and evaluation of sustained release bilayer tablets of propranolol hydrochloride” Acta Pharm. 2007 Dec; 57(4):479-89.
16.Divya.A,K.kavitha,M.Rupesh kumar,Dakshayani S,Jagadesh Singh SD Bilayer tablet technology:An overview”Journal of applied pharmaceutical science 2011.
17. Nirmal J, Saisivam S, Peddanna C, Muralidharan S, Godwinkumar S, Nagarajan M Bilayer tablets of atorvastatin calcium and nicotinic acid: formulation and evaluation”. Chem Pharm Bull (Tokyo). 2008 Oct;56(10):1455-8.
18. Kumar VB,Prasad G,Ganesh B,Swathi C,Rashmi A,Reddy AG.Development and evaluation of Guafenesin bilayer tablet,Int.J.Pharm.Sci.NanoTech.2010;3(3):1122-1128.
19. Rao NGR,Yadav A,Kulkarni U.Formulation and evaluation of zero order release glipizide bilayer matrix tablet using natural and synthetic polymers.2010;2(1):34-42.
20.Kartheikeyini CS,Jayaprakash S,Abirami A,Halith MS, Formulation and evaluation of Aceclofenac sodium bilayer tablets.Int.J.ChemTech.Res.2009;1(4):1381-1385.
21. Shirwaikar AA,Shrinatha A, sustained release bilayer tablet Of diltiazem Hcl us Insoluble matrix system. Int.J.Pharm.Sci.2004;6(4):433-437.
22. Prasanthi NL,Manikiran SS,Rao NR, Fomulation and evaluate bilayer tablet of propranolol Hcl by using natural gums. Asian J.Pharma.Clin.Res.2010;3(2):104-105.
23. Nagaraju R,Kaza R. Fomulation and evaluate bilayer sustained release tablets of Salbutamol and Theophylline International journal of pharmaceutical sciences and nanotechnology 2009;vol.2.
24.Sale V.V,P.K. Choudhari, A.M.Avachat,S.M.Sheikh,‘Development and characterization of bilayer controlled release tablet of Tramadol Hcl ‘In AAPS-000667,2008.
25.N.G.Raghavendra rao,Ashok yadav,et al.Formulation and evaluation of zero order release glipizide bilayered matrix tablets using natural and synthetic polymers.International journal of current pharmaceutical research 2010;2(1):pp 34-42.
26. Mandal U, Pal TK. Formulation and in vitro studies of a fixed-dose combination of a bilayer matrix tablet containing metformin HCl as sustained release and glipizide as immediate release”. Drug Dev Ind Pharm. 2008 Mar; 34(3):305-13
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How to Cite
KUMAR, K. K., M. Narasimha reddy, and R. KISHORE. “FORMULATION AND EVALUATION OF BILAYERMATRIX TABLET OF PIOGLITAZONE HCL METFORMIN HCL USP 15MG&500MG”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 6, no. 7, Aug. 2013, pp. 155-61, https://innovareacademics.in/journals/index.php/ajpcr/article/view/300.
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