BIOMARKER POTENTIAL OF IQ-DOMAIN GTPASE-ACTIVATING PROTEINS FAMILY PROTEIN IN PANCREATIC CANCER: A MINI REVIEW
Objectives: Our present study was done to understand molecular regulatory mechanisms of IQGAP proteins and their potentials as biomarker in pancreatic cancer.
Methods: In this review, relevant studies were obtained by assessing the PubMed database using the combination of words that included â€œIQGAPâ€ and â€œpancreatic cancerâ€.
Results: There is an increasing evidence showing that the expression of IQGAP1 and IQGAP3 is positively correlated with tumorigenesis; however, IQGAP2 might play a role to suppress tumor progression.
Conclusion: IQGAP proteins might have potentials as predictive and prognostic biomarker for human pancreatic cancer.
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