• Anton Sumarpo Department of Biochemistry, Faculty of Medicine, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia.
  • Agnes Anania Triavika Sahamastuti Department of Pharmacy, Indonesia International Institute for Life Sciences, Jakarta, Indonesia.
  • Gisella Edny Tjugianto Department of Pharmacy, Indonesia International Institute for Life Sciences, Jakarta, Indonesia.
  • Kenny Yonathan Department of Biomedicine, Indonesia International Institute for Life Sciences, Jakarta, Indonesia.
  • David Agustriawan Department of Bioinformatics, Indonesia International Institute for Life Sciences, Jakarta, Indonesia.


Objectives: Our present study was done to understand molecular regulatory mechanisms of IQGAP proteins and their potentials as biomarker in pancreatic cancer.

Methods: In this review, relevant studies were obtained by assessing the PubMed database using the combination of words that included IQGAP†and pancreatic cancerâ€.

Results: There is an increasing evidence showing that the expression of IQGAP1 and IQGAP3 is positively correlated with tumorigenesis; however, IQGAP2 might play a role to suppress tumor progression.

Conclusion: IQGAP proteins might have potentials as predictive and prognostic biomarker for human pancreatic cancer.

Keywords: Pancreatic cancer, IQ-domain GTPase-activating proteins, Tumor biomarker, Early detection, Prognostic value.


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How to Cite
Sumarpo, A., A. A. T. Sahamastuti, G. E. Tjugianto, K. Yonathan, and D. Agustriawan. “BIOMARKER POTENTIAL OF IQ-DOMAIN GTPASE-ACTIVATING PROTEINS FAMILY PROTEIN IN PANCREATIC CANCER: A MINI REVIEW”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 11, no. 15, Oct. 2018, pp. 24-27, doi:10.22159/ajpcr.2018.v11s3.30021.
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