EVALUATION OF ACID HYDROLYSED STARCH DERIVED FROM DIGITARIA IBURUA AS BINDER

Authors

  • GIDEON O OKPANACHI
  • Hassan Musa
  • Adamu B Isah

Abstract

 

 Objective: This research work was aimed at investigating the binding properties of Digitaria iburua starch (DS) and acid hydrolyzed starch or microcrystalline starch (MCS) in the formulation of metronidazole (MET) tablet comparing it with gelatin (GLT) as a standard binder.

Methods: DS was obtained from steeping the D. iburua grains in water. MCS was produced using 6 N HCl at 50°C for 24 hrs. The dilution potential test was conducted. MET granules of binder concentrations (2.5, 5.0, 7.5, 10.0 and 12.5% w/v) of DS and MCS was prepared by wet granulation method and compared with GLT. The granules flow properties were evaluated. The particle size distribution of the granules was determined. The quality of tablets was assessed by standard methods.

Results: A yield of 62.88% w/w DS was obtained whereas MCS was found to be 85.14% w/w. The MCS was unable to bind MET at all ratios. The granules had good flow and compressible properties and are uniformly distributed. The crushing strength (CS) of the binder types is ranked: GLT>MCS>DS. The friability (FR) values decreased with increase in binder concentration for all binder types. Only FR at 12.5% w/v of MCS and GLT was <1%. The disintegration time (DT) increased with increase in binder concentration. The (CS/FR)/DT values of DS and MCS obtained >2.

Conclusion: The Carr's index, Hausner's ratio and (CS/FR)/DT values suggests that DS and MCS are poor binders.

Keywords: Acid hydrolyzed starch, Excipients, Digitaria iburua, Metronidazole.

 

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Published

2014-11-01

How to Cite

OKPANACHI, G. O., H. Musa, and A. B. Isah. “EVALUATION OF ACID HYDROLYSED STARCH DERIVED FROM DIGITARIA IBURUA AS BINDER”. Asian Journal of Pharmaceutical and Clinical Research, vol. 7, no. 5, Nov. 2014, pp. 160-3, https://innovareacademics.in/journals/index.php/ajpcr/article/view/3043.

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