ASSESSING THE CHARACTERIZATIONS OF KETOPROFEN LOADED AND UNLOADED VIRGIN COCONUT OIL (VCO) BASED CREAMY NANOEMULSION
Objective: The aim was to analyze the characterization of the formulations prepared with and without ketoprofen in virgin coconut oil (VCO) based
Methods: The primary emulsions were prepared by magnetic stirring, and the process was continued with high sheer homogenization, aiming
for nanoemulsion. The present study evaluated the characteristic properties of emulsions such as; droplets size, pH, viscosity, creaming index and
Results: Droplets size falls within the range; 144.9-664.7 nm and pH value was 4.91-5.66. It was noted homogenization process improved the
characteristics of the emulsion, mainly droplets size and viscosity. Further, found the incorporation of ketoprofen affects the droplets size of emulsions
significantly, this could be due to the amphiphilic nature of drug that can affect the core of the surfactants. Characteristic properties of VCO based
emulsions were affected by high shear homogenization and incorporation of drug.
Conclusion: Characteristic properties of 2.5% (w/w) ketoprofen loaded 23.60% VCO: 30.53%, Tween 80Â®: 45.87% water creamy emulsion is suitable
for topical application.
Keywords: Ketoprofen, Virgin coconut oil, Nanoemulsion.
2. Rybunski WV, Foster T. Fundamentals of the development and applications of new emulsion types. Prog Coll Polym Sci 1998;109:126.
3. Aichele CP. Characterizing Water-in-oil Emulsions with Application to Gas Hydrate Formation. 1st ed. Unites States: ProQuest LLC; 2009.
4. Langley CA, Belcher D. Emulsions. Pharmaceutical Compounding and Dispensing. 1st ed. UK: Pharmaceutical Press; 2008.
5. Bernardi DS, Pereira TA, Maciel NR, Bortoloto J, Viera GS, Oliveira GC, et al. Formation and stability of oil-in-water nanoemulsions containing rice bran oil: In vitro and in vivo assessments. J Nanobiotechnology 2011;9:44.
6. Sharma N, Bansal M, Visht S, Sharma PK, Kulkarni GT. Nanoemulsion: A new concept of delivery system. Chron Young Sci 2010;1 Suppl 2:2â€‘5.
7. Koteswari P, Krishna SR, Reddy VP, Narasu LM. Formulation and preparation of felodipine nanoemulsions. Asian J Pharm Clin Res 2011;4 Suppl 1:116-7.
8. Kabri TH, Arab-Tehrany E, Belhaj N, Linder M. Physico-chemical characterization of nano-emulsions in cosmetic matrix enriched on omega-3. J Nanobiotechnology 2011;9:41.9. Bouchemal K, BrianÃ§on S, Perrier E, Fessi H. Nano-emulsion formulation using spontaneous emulsification: Solvent, oil and surfactant optimisation. Int J Pharm 2004;280(1-2):241-51.
10. Al-Edresi S, Baie S. Formulation and stability of whitening VCO-in-water nano-cream. Int J Pharm 2009;373(1-2):174-8.
11. Jones D. Pharmaceutics â€“ Dosage Form and Design. 1st ed. UK: Pharmaceutical Press; 2008.
12. Khan BA, Akhtar N, Khan HS, Waseem K, Mahmood T, Rasul A, et al. Basics of pharmaceutical emulsions: A review. Afr J Pham Pharmacol 2011;5 Suppl 25:2615-25.
13. McClements DJ. Critical review of techniques and methodologies for characterization of emulsion stability. Crit Rev Food Sci Nutr 2007;47(7):611-49.
14. Sanjeewani NA, Sakeena MH. Formulation, characterization and stability evaluation of virgin coconut oil based emulsion. Peradeniya University Research Sesssions. Vol. 17. 2012. p. 170.
15. Mauludin R, Pamudji JS, Ruyanti D. Dissolution improvement of ketoprofen tablets by solid dispersion method. Asian J Pharm Clin Res 2011;4(4):119.
16. Sakeena MH, Muthanna FA, Ghassan ZA, Kanakal MM, Elrashid SM, Munavvar AS, et al. Formulation and in vitro evaluation of ketoprofen in palm oil esters nanoemulsion for topical delivery. J Oleo Sci 2010;59(4):223-8.
17. Rhee YS, Choi JG, Park ES, Chi SC. Transdermal delivery of ketoprofen using microemulsions. Int J Pharm 2001;228(1-2):161-70.
18. Dhamankar AK, Manwar JV, Kumbhar DD. The novel formulation design of O/W microemulsion of ketoprofen for improving transdermal absorption. Int J PharmTech Res 2009;1-4:1449-57.
19. Gullapalli RP, Sheth BB. Influence of an optimized non-ionic emulsifier blend on properties of oil-in-water emulsions. Eur J Pharm Biopharm 1999;48(3):233-8.
20. Suraweera RK, Pasansi HG, Herath HM, Wickramaratne DB, Sudeshika SH, Niyangoda D, et al. Formulation and stability evaluation of ketoprofen loaded virgin coconut oil based creamy emulsion. Int J Pharm Pharm Sci 2014;6-8:249-54.
21. Pasansi HG, Suraweera RK, Sakeena MH. Pre-formulation srtudies by constructing ternary phase diagrams for virgin coconut oil (VCO) based emulsions. Proceedings of Peradeniya University International Research Sessions, Sri Lanka. Vol. 18. 2014. p. 349.
22. Suraweera RK, Pasansi HG, Sakeena MH. Effect of drug concentration on droplets size in virgin coconut oil (VCO) based emulsion. Proceedings of Peradeniya University International Research Sesssions, Sri Lanka. Vol. 18. 2014. p. 351.
23. Mandal A, Samanta A, Bera A, Ojha K. characterization of oil- water emulsion and its use in enhanced oil recovery. Ind Eng Chem Res 2010;49:12756-61.
24. Anisa AN, Nour AH. Affect of viscosity and droplet diameter on water-in-oil (w/o) emulsions: An experimental study. World Acad Sci Eng Technol 2010;38:692-4.
25. Almutairi SH. Effect of droplets size on the behavior and characteristics of emulsified acid. Petroleum Engineering of Texas A&M University; 2008. p. 88.
26. Foster T. Microemulsions as Compartmentalised Reaction Media: Structural Characterization of Water-in-Oil Microemulsions. Vol. 7. Gottingen: Cuvillier Verlag; 2007.
27. Worachun N. Development of microemulsion for transdermal drug delivery of ketoprofen. Unpublished Manuscript. Thailand: Silpakorn University; 2010. p. 1-42.
28. Akhtar N, Yazan Y. Formulation and characterization of a cosmetic multiple emulsion systems containing macadamia nut oil and two antiaging agents. Turk J Pharm Sci 2005;2-3:173-84.
29. Paudel KS, Milewski M, Swadley CL, Brogden NK, Ghosh P, Stinchcomb AL. Challenges and opportunities in dermal/transdermal delivery. Ther Deliv 2010;1(1):109-31.
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