• Vijey Aanandhi M Department of Pharmaceutical Chemistry and Analysis, School of Pharmaceutical Sciences, Vels Institute of Science, Technology and Advanced Studies, Chennai, Tamil Nadu, India.
  • Anbhule Sachin J Department of Pharmaceutical Chemistry and Analysis, School of Pharmaceutical Sciences, Vels Institute of Science, Technology and Advanced Studies, Chennai, Tamil Nadu, India.


Objective: The aim of the present study is to synthesize novel benzimidazole derivatives as potent antifungal agents.

Methods: 2-chloromethyl-1H-benzimidazole has been synthesized by refluxing o-phenylenediamine with chloroacetic acid in the presence of 5N HCL. Further, N-substituted benzimidazole derivatives containing various heteroamines and aromatic compounds were synthesized. These, finally, prepared derivatives were kept for in vitro antifungal property.

Results: A novel series of antifungal agents, containing benzimidazole nucleus as a basic skeleton, has been synthesized.

Conclusion: The synthesized novel benzimidazole derivatives exhibit moderate activity (VMSA 1, 2, 8), some compounds showed significant activity (VMSA 6, 9, and 10), and compound VMSA 4 and 5 exhibits maximum activity.

Keywords: Benzimidazole, In vitro, Significant, Antifungal activity, Aromatic.


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How to Cite
M, V. A., and A. S. J. “SYNTHESIS, CHARACTERIZATION, AND EVALUATION OF ANTIFUNGAL PROPERTIES OF SUBSTITUTED BENZIMIDAZOLE ANALOG”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 11, no. 16, Dec. 2018, pp. 66-69, doi:10.22159/ajpcr.2018.v11s4.31677.
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