• Sowmyalakshmi Venkataraman 1Department of Pharmaceutical Chemistry and Analysis, School of Pharmaceutical Sciences, Vels Institute of Science, Technology and Advanced Studies (VISTAS), Pallavaram, Chennai, Tamil Nadu, India.
  • Gunda Srilakshmi 2Research Scholar, Department of Pharmaceutical Chemistry and Analysis, School of Pharmaceutical Sciences, Vels Institute of Science, Technology and Advanced Studies (VISTAS), Pallavaram, Chennai,Tamil Nadu, India


Context: The focus of the present review is to compile the different phytochemical constituents and pharmacological activities of bignoniaceous plants, namely Kigelia africana and Mansoa alliacea.

Objective: Medicinal plants are routinely used in clinical practice for the treatment of various diseases of human beings over thousands of years across the world. In rural areas of the developing countries, they are still used in practice due to the easy availability of the medication. The main objective of this work is to explore the phytochemical studies and biological activities of plants belonging to Bignoniaceae family.

Methods: The present study also discusses about the different phytochemical constituents of K. africana and M. alliacea that were isolated and characterized using various analytical methods. Different extracts of these plants were subjected to different in vitro anticancer, analgesic, antimicrobial, and antimalarial activities using earlier reported methods were also discussed.

Results: K. africana is commonly referred to as sausage or cucumber tree due to its huge sausage or cucumber-like fruit. These plants find application as traditional medicine for treating several ailments such as malignant tumor, ulcer, aging, and malaria among others. It is conjointly used for the treatment of reproductive organ infections, renal ailments, dizziness, epilepsy, sickle cell disease, depression, metabolism disorders, skin grievance, leprosy, impetigo, helminthic infections, athlete’s foot, tumors, etc. These plant extracts have also been used as a cosmetic by enhancing the collagen action and thus exhibit antiaging properties.

Conclusion: The present study attempts to provide collective information on various phytochemical constituents and pharmacological actions of K. africana and M. alliacea belonging to Bignoniaceae. This review in its present form is believed to help the researchers to provide adequate information about the chemical constituents and biological uses of these plants.

Keywords: Bignoniaceae, Kigelia africana, Mansoa alliacea, Phytochemical studies, Pharmacological studies.


1. Cragg GM, Newman DJ. Medicinals for the millennia: The historical record. Ann N Y Acad Sci 2001;953:3-25.
2. Otimenyin SO, Uzochukwu DC. Spasmolytic and anti-diarrhea effects of the bark of Erythrina senegalensis and the root of Kigelia africana. Asian J Pharm Clin 2012;3:11-4.
3. Olatunji AG, Atolani O. The comprehensive scientific demystification of Kigelia africana: A review. Nat Prod Rad 2009;8:190-7.
4. Jackson S, Beckett K. Sausage tree Kigelia pinnata: An ethnobotanical and scientific review, herbal gram. Am Bot Counc 2012;94:48-59.
5. Khan SS, Malhotra D. Plantagentic diversity exploration evaluation, conservation: Angiospermic diversity in Bhopal-reassessment with particular reference to endangered species and their conservation. Vol. 232. East: West Press Pvt Ltd.; 2002. p. 234.
6. Mathad P, Shrishail C. Floristic diversity of a famous historical barid-shahi fort of boidarin Karnataka. Indian J For 2008;31:577-80.
7. Arana VF. Control de Hipsiphyla grandella Zeller en plantaciones de Cedrela odorata L. (cedro rojo) con Mansoa alliacea (Lam) A. H Gentry (ajo sacha). Conocimiento 2005;8:59-67.
8. Agra MF, Silva KN, Basilo IJ, Franca PF, Barbosa-Filho JM. Survey of medicinal plants used in the region Northeast of Brazil. Rev Bras Famacogn 2008;18:472-508.
9. Ariga T, Seki T. Antithrombotic and anticancer effects of garlic-derived sulfur compounds: A review. Biofactors 2006;26:93-103.
10. Burkil HM. The Useful Plants of Tropical West Africa. 2nd ed. England: Royal Botanical Garden Kew; 1985. p. 254-57.
11. Gill LS. Ethnomedicinal Uses of Plants in Nigeria. Benin City: Uniben Press; 1992. p. 143.
12. Pooley E. The Completed Guide to Trees of Natal, Zululand, and Transkei. Durban: Natal Flora Publications Trust; 1993. p. 22-4.
13. Irvine FR. Woody Plants of GHANA, with Special References to their Uses. London, United Kingdom: Oxford Univesity Press; 1961. p. 736-40.
14. Walt JM, Breyer-Bradwijk MG. The Medicinal and Poisonous Plants of Southern and Eastern Africa. Livingstone: E. & S. Livingstone; 1962. p. 52.
15. Lanalice RF, Tavares-Martins AC. Chemical and ethnopharmacology mystical plants in an amazonian community. Rev Fitos 2016;10:220-372.
16. Abril RV, Vasquez TE, Lazo JA, Banguera DV, Guyasamin PD, Vargas JK, et al. The use of medicinal plants by rural populations of Pastaza Province in the Ecuadorian amazon. Acta Amazonica 2016;46:355-66.
17. Gouda YG, Abdel-Baky AM, Mohamed KM, Darwish FM, Kasai R, Yamasaki K, et al. Phenylpropanoid and phenylethanoid derivatives from Kigelia pinnata DC. Fruits. Nat Prod Res 2006;20:935-9.
18. Gouda YG, Gouda YG, Abdel-Baky AM, Mohamed KM, Darwish FM, Kasai R, et al. Iridoids from Kigelia pinnata DCC, fruits. Phytochemistry 2003;63:887-92.
19. Govindachari TR, Patankar SJ, Viswanathan N. Isolation and structure of new dihydroios coumarins from Kigelia pinnata. Phytochemistry 1971;10:1603-6.
20. Joshi KC, Singh P, Taneja S, Cox PK. New terpenoid aldehydes from Kigelia pinnata crystal structure of pinnatal. Tetrahedron 1982;38:2703-8.
21. Zoghbi MG, Ramos LS, Maia JG, Miriam L, da Silva ML, Luz AI. Volatile sulfides of the amazonian garlich bush. J Agric Food Chem 1904;32:1009-10.
22. Zoghbi MG, Oliveira J, Skelding GM, Guilhon P. The genus Mansoa (Bignoniaceae): A source of organosulphur compounds. Rev Bras Farmacogn 2009;19:795-804.
23. Zoghbi MD, Andrade EH, Maia JG. Volatile constituents from Adenocalymma alliaceum Miers and Petiveria alliaceae L. Two medicinal herbs of the amazon. Flavour Fragr J 2009;2002:133-5.
24. da Silverira GD, Motta MJ, Muller LS, Lameira O, Athayde ML, Piana M, et al. Determination of phenolic antioxidants in amazonian medicinal plants by HPLC with pulsed amperometric detection. J Liq Chromatogr Relat Technol 2015;3:1-8.
25. Gobo LA, Viana C, Lameira OA, de Carvalho LM. A liquid chromatography-atmospheric pressure photoionization tandem mass spectrometric (LC-APPI-MS/MS) method for the determination of triterpenoids in medicinal plant extracts. J Mass Spectrom 2016;51:558-65.
26. Saez AL, Soto JP. Fitoquimica y valor ecologico del olor a ajo en los vegetables. Med Naturista 2010;4:15-23.
27. Pires FB, Dolwitsch CB, Pra VD, Monego DL, Schneider VM, Loose RF, et al. An overview about the chemical composition and biological activity of medicinal species found in the Brazilian amazon. J Appl Pharm Sci 2016;6:233-8.
28. Jackson SJ, Houghton PJ, Retsas S, Photiou A. In vitro cytotoxicity of norviburtinal and isopinnatal from Kigelia pinnata against cancer cell lines. Planta Med 2000;66:758-61.
29. Inoue K, Inoue H, Chen C. Quinones and related compounds in higher plants, a naphthoquinone and a lignin from the wood of Kigelia pinnata. Phytochemistry 1981;20:2271-6.
30. Hussain H, Krohn K, Ahmad UV, Miana GA, Green IR. Lapachol: An overview. ARKIVOC 2007;2:145-71.
31. Houghton PJ, Photiou A, Uddin S, Shah P, Browning M, Jackson SJ, et al. Activity of extract of Kigelia pinnata against melanoma and renal carcinoma cell lines. Planta Med 1994;60:430-3.
32. Rao MM, Kingston DG. Plant anticancer agents: Isolation and structure elucidation of new cytotoxic quinines from Tabebuia cassinoides. J Nat Prod 1982;45:600-4.
33. Towne CM, Dudt JF, Ray DB. Effect of Mansoa alliacea (Bignoniaceae) leaf extract on embryonic and tumorigenic mouse cell line. J Med Plants Res 2015;9:799-805.
34. Owolabi OJ, Omogbai EK. Analgesic and anti-inflammatory activities of the ethanolic stem bark extract of Kigelia africana (Bignoniaceae). Afr J Biotechnol 2007;6:582-5.
35. Forschung N. Use of Mixtures, Which Contain Parts of the Plant Kigelia africana. Hans Knoll Institute for Naturstoff Patent Number DE10200490; 2003.
36. Pires FB, Dolwitsch CB, Pra VD, Monego DL, De Carvalho LM, Viana C, et al. Qualitative and quantitative analysis of the phenolic content of Connarus var angustifolius, Cecropia obtuse, Ceropial palmata and Mansoa alliacea based on HPLD-DAD and UHP;LC-ESI-MS/MS. Rev Bras Farmacogn 2017;27:426-33.
37. Weiss CR, Moideen SV, Croft SL, Houghton PJ. Activity of extract and isolated naphthoquinones from Kigelia pinnata against Plasmodium falciparum. J Nat Prod 2000;63:1306-9.
38. Ruiz L, Maco M, Cobos M, Gutierrez-Choquevilca AL, Roumy V. Plants used by native amazonian groups from many rivers (Peru) for the treatment of malaria. J Ethnopharmacol 2011;133:917-21.
39. Owolabi OJ, Amaechina FC, Eledan AB. Central nervous system stimulant effect of the ethanolic extract of Kigelia africana. J Med Plants Res 2008;2:20-3.
40. Akunyili DN, Houghton PJ, Raman A. Antimicrobial activities of the stem bark of Kigelia pinnata. J Ethnopharmacol 1991;35:173-7.
41. Binutu OA, Adesogan KE, Okogun JI. Antibacterial and antifungal compounds from Kigelia pinnata. Planta Med 1996;62:352-3.
42. Grace OM, Light ME, Lindsey KI, Mulholland DA, Vanstaden J, Jager AK. Antibacterial activity and isolation of active compounds from the fruit of the traditional African medicinal tree Kigelia africana. S Afr J Bot 2002;68:220-2.
43. Freixa B, Vila R Vargas L, Lozano N, Adzet T, Canigueral S. Screening for antifungal activity of nineteen Latin American plants. Phytother Res 1998;12:427-30.
44. Akah PA. The antidiarrheal activity of Kigelia africana in experimental animals. J Herbs Spices Med Plants 1998;2:31-8.
45. Kela SL, Ogunsusi RA, Ogbogu VC, Nwude N. Screening of some Nigerian plants for molluscicidal activity. Rev Elev Med Vet Pays Trop 1989;42:195-202.
46. Sharma RK. Phytosterols: Wide spectrum antibacterial agents. Bioorg Chem 1993;21:49-60.
47. Dampier C. Cosmetic Compositions with High Viscosity for Female Breast Care Containing Kigelia Extract. Patent Number: US 2002/0176874; 2002.
48. Isamu M. Skin Care Preparation. Patent Number: JP2003137763; 2003.
49. Martins N, Petropoulos S, Ferreira IC. Chemical composition and bioactive compounds of garlic (Allium sativum L), as affected by pre and post-harvest conditions-a review. Food Chem 2016;211:41-50.
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How to Cite
Venkataraman, S., and G. Srilakshmi. “PHYTOCHEMICAL CONSTITUENTS AND PHARMACOLOGICAL ACTIVITIES OF Kigelia Africana AND Mansoa Alliacea - A COMPREHENSIVE REVIEW”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 11, no. 16, Dec. 2018, pp. 29-32, doi:10.22159/ajpcr.2018.v11s4.31703.
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