A PROSPECTIVE OBSERVATIONAL STUDY ON PATTERN OF ADVERSE DRUG REACTION TO ANTIBIOTICS COMMONLY PRESCRIBED IN THE HOSPITALIZED PEDIATRIC PATIENTS

Authors

  • Malarkodi Velraj Department of Pharmacognosy, School of Pharmaceutical Sciences, Vel’s Institute of Sciences, Technology and Advanced Studies, Chennai, Tamil Nadu, India.
  • MOHAN BABU V

DOI:

https://doi.org/10.22159/ajpcr.2018.v11s4.31711

Keywords:

Adverse drug reactions, Antibiotics, World Health Organization causality assessment, Pediatrics

Abstract

Objective: Antibiotics are the almost usually specified or authorized medication in hospitals, and antibiotics were found to be the almost bothersome classes of drugs providing or endowing to adverse drug reactions (ADRs). Therefore, the present study was conducted to check or regulate the precautions (ADRs) of antibiotics usually specified or authorized in the pediatrics unit.

Methods: A potential, experimental, non-interventionist study was conducted or executed in the Department of Pediatrics for a time of 6 months to analyze the ADRs reported spontaneously from the hospital using patient statistics, objective and medication information, data of ADRs, onset time, causal drug details, outcome, and severity.

Results: Among 72 ADRs observed, beta-lactams and quinolones were set up to be contributing the highest number of ADRs. The duct or abdominal system was the almost commonly affected organ, followed by respiratory system and the cardiovascular system. The assessment by the World Health Organization causation estimation scale demonstrated that 5.56% ADRs were certain, 55.56% were possible, 30.56% were probable, and 8.33% were unlikely.

Conclusion: Thus, the pattern of ADRs occurring in the pediatric population was observed and assessed. Early recognition and management of ADRs are essential to reduce the burden of ADRs

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References

Tripathi KD. Adverse drug effects. In: Essentials of Medical Pharmacology. 6th ed. New Delhi: Jaypee Brothers; 2007.

Dhar K, Chauhan S, Sharma J, Gaur P, Chopra VS, Bajaj U. To monitor the adverse drug reactions and safety of medicines commonly prescribed at obstetrics and gynaecology unit in a tertiary care hospital. Indian J Pharm Biol Res 2014;2:112-92.

Stavreva G, Pendicheva D, Pandurska A, Marev R. Detection of adverse drug reactions to antimicrobial drugs in hospitalized patients. Trakia J Sci 2008;6:7-9.

Jayanthi CR, Chaithra KN, Reddy NS. A profile of adverse drug reactions to antimicrobial agents at a tertiary care hospital. Indian J Pharm Pharm 2017;4:16-21.

Raja S, Rani J, Kala R. Pattern of adverse drug reaction in a tertiary care teaching hospital: A cross-sectional study. Asian J Pharm Clin Res 2017;10:170-3.

Dhar K, Sinha A, Gaur P, Goel R, Chopra VS, Bajaj U. Pattern of adverse drug reactions to antibiotics commonly prescribed in a tertiary care teaching hospital. J Appl Pharm Sci 2015;5:78-2.

The Use of the WHO–UMC System for Standardised Case Causality Assessment. Available from: http://www.WHO-UMC.org/graphics/4409.pdf. [Last accessed on 2014 Oct 08].

Hussain MM, Girhepunje K, Pal K, Siddiqua SS. Incidence of adverse drug reactions in a tertiary care hospital. Sch Res Lib Pharm Lett 2010;2:358-68.

Oshikoyo KA, Senbanjo IO. Providing safe medicines for children in Nigeria. Ann Afr Med 2010;9:3-12.

Beard K, Lee A, editors. Adverse Drug Reaction. 1st ed. London: Pharmaceutical Press; 2006.

Horen B, Montastruc JL, Lapeyre-Mestre M. Adverse drug reactions and off-label drug use in pediatrics outpatients. Br J Clin Pharmacol 2002;54:665-70.

Novotný J, Novotný M. Adverse drug reactions to antibiotics and major antibiotic drug interactions. Gen Physiol Biophys 1999;18 Spec No:126-39.

Tünger O, Dinç G, Ozbakkaloglu B, Atman UC, Algün U. Evaluation of rational antibiotic use. Int J Antimicrob Agents 2000;15:131-5.

Pirmohamed M, Breckenridge AM, Kitteringham NR, Park BK. Adverse drug reactions. BMJ 1998;316:1295-8.

Edwards IR, Aronson JK. Adverse drug reactions: Definitions, diagnosis, and management. Lancet 2000;356:1255-9.

Alomar MJ. Factors affecting the development of adverse drug reactions (review article). Saudi Pharm J 2014;22:83-94.

Priyadharshini R, Surendiran A, Adithan C, Sreenivasan S, Sahoo FK. A study of adverse drug reactions in paediatrics patients. J Pharmacol Pharmacother 2011;2:277-80.

Palanisamy S, Kottur SG, Kumaran A, Rajasekarana A. A study on assesment, monitoring and reporting of adverse drug reactions in Indian hospital. Asian J Pharm Clin Res 2011;4:112-6.

Jindal M, Sharma AK. Antimicrobial related drug reactionin a tertiary care hospital. Asian J Pharm Clin Res 2017;10:229-31.

Published

28-12-2018

How to Cite

Velraj, M., and M. B. V. “A PROSPECTIVE OBSERVATIONAL STUDY ON PATTERN OF ADVERSE DRUG REACTION TO ANTIBIOTICS COMMONLY PRESCRIBED IN THE HOSPITALIZED PEDIATRIC PATIENTS”. Asian Journal of Pharmaceutical and Clinical Research, vol. 11, no. 16, Dec. 2018, pp. 118-20, doi:10.22159/ajpcr.2018.v11s4.31711.

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