ALOE VERA: AN ASSURED WEIGHT LOSS DIET – AN APPROACH TOWARD IMPROVING THE JUICE PALATABILITY AND IN SILICO ANALYSIS

  • DISALVA X Department of Hotel and Catering Management, Vels Institute of Science, Technology and Advanced Studies, Chennai, Tamil Nadu, India.
  • SHARANYA M Department of Bioinformatics, Vels Institute of Science, Technology and Advanced Studies, Chennai, Tamil Nadu, India.
  • MAHENDRAN RADHA Department of Bioinformatics, Vels Institute of Science, Technology and Advanced Studies, Chennai, Tamil Nadu, India.

Abstract

Objective: Obesity is an epidemic disease act as causative for global death. The principal aim of this study is to create an obesity treatment beverage that is palatable and readily acceptable to the public. Aloe vera juice is one such drink known to assist in reducing obesity. This juice is sold at several places in Chennai and more easily available for morning walkers along the Marina beach. Although known for its benefits in promoting a slim and fit physique, its taste is less palatable. The objective of this study is to develop a concoction that will make the A. vera juice tasty without compromising its nutritive value.


Materials and Methods: The taste is achieved by the addition of various fruit juices such as orange, lime, sweet lime, muskmelon, and pineapple with honey and stevia for sweetening. The weight loss ability of the prepared drinks is evaluated using pancreatic lipase inhibitory and the presence of phytochemicals. To the credit, the present study also determines the efficiency of A. vera compounds for its antiobesity property through in silico techniques. The significant interaction exhibited by the compounds with the antiobesity target inositol hexakisphosphate kinase 1 (IP6K1) was discussed.


Results: The recipe B containing orange juice: A. vera juice: stevia in the ratio 3:3:1 had good taste and the significant lipase activity. The phytochemicals present in the A. vera are tannins, flavonoids, alkaloids, steroids, and polyphenols, and these phytochemicals are observed having significant interaction with protein IP6K1. Aloin A and aloe emodin had significant Glide score and interactions with active site residues.


Conclusion: Natural herbal products for weight reduction may be effective in the treatment of obesity and associated disorders. The potential lipase inhibition activity of juice may be due to the presence of various phytochemicals such as flavonoids, polyphenol etc. in the Aloe vera.

Keywords: Obesity,, Aloe vera,, Weight loss,, Aloe vera juice,, In silico analysis,, Docking studies,, Inositol hexakisphosphate kinase 1.

References

1. Berthoud HR, Klein S. Advances in obesity: Causes, consequences, and therapy. Gastroenterology 2017;152:1635-7.
2. Guthold R, Stevens GA, Riley LM, Bull FC. Worldwide trends in insufficient physical activity from 2001 to 2016: A pooled analysis of 358 population-based surveys with 1•9 million participants. Lancet Glob Health 2018;6:e1077-86.
3. Karam JG, McFarlane SI. Secondary causes of obesity. Therapy 2007;4:641-50.
4. Bollapragada MK, Shantaram M, Kumar RS. Obesity: Development, epidemiology, factors affecting, quantity, health hazards, management and natural treatment a review. Int J Pharm Pharm Sci 2017;9:12-26.
5. Christaki EV, Florou-Paneri PC. Aloe vera: A plant for many uses. J Food Agric Environ 2010;8:245-9.
6. Ahlawat KS, Khatkar BS. Processing, food applications and safety of Aloe vera products: A review. J Food Sci Technol 2011;48:525-33.
7. Subhashis P, Dutta S, Chaudhuri TK, Bhattacharjee SB. Anti-inflammatory and protective properties of Aloe vera leaf leaf crude gel in carrageenan induced acute inflammatory rat models. Int J Pharm Pharm Sci 2014;6:368-71.
8. Singh A, Singh AK. Optimization of processing variables for the preparation of herbal bread using Aloe vera gel. J Food Sci Technol 2009;46:335-8.
9. Vinson JA, Al Kharrat H, Andreoli L. Effect of Aloe vera preparations on the human bioavailability of Vitamins C and E. Phytomedicine 2005;12:760-5.
10. Borrelli F, Izzo AA. The plant kingdom as a source of anti-ulcer remedies. Phytother Res 2000;14:581-91.
11. Chakraborty A, Koldobskiy MA, Bello NT, Maxwell M, Potter JJ, Juluri KR, et al. Inositol pyrophosphates inhibit akt signaling, thereby regulating insulin sensitivity and weight gain. Cell 2010;143:897-910.
12. Zhu Q, Ghoshal S, Rodrigues A, Gao S, Asterian A, Kamenecka TM, et al. Adipocyte-specific deletion of ip6k1 reduces diet-induced obesity by enhancing AMPK-mediated thermogenesis. J Clin Invest 2016;126:4273-88.
13. Balunas MJ, Kinghorn AD. Drug discovery from medicinal plants. Life Sci 2005;78:431-41.
14. Liu J, Pei M, Zheng C, Li Y, Wang Y, Lu A, et al. A systems-pharmacology analysis of herbal medicines used in health improvement treatment: Predicting potential new drugs and targets. Evid Based Complement Alternat Med 2013;2013:938764.
15. Sofowora A. Medicinal Plants and Traditional Medicinal in Africa. 2nd ed. Sunshine House, Ibadan, Nigeria: Spectrum Books Ltd.; 1993.
16. Trease GE, Evans WC. Pharmacognosy. 13th ed. London: ELBS/ Bailliere Tindall; 1989.
17. Harborne JB. Phytochemical methods. London chapman and Hall Ltd., 1984.
18. Choi SJ, Hwang JM, Kim SI. A colorimetric microplate assay method for high throughput analysis of lipase activity. J Biochem Mol Biol 2003;36:417-20.
19. Kekuda TR, Raghavendra HL, Mallikarjun N, Venugopal TM, Kumar HS. Elemental composition, anticarcinogenic, pancreatic lipase inhibitory and cytotoxic activity of Artocarpus lakoocha Roxb pericarp. Int J Drug Dev Res 2012;4:330-6.
20. Prakash D, Gupta C, Sharma G. Importance of phytochemicals in nutraceuticals. J Chin Med Res Dev 2012;1:70-8.
21. Birari RB, Bhutani KK. Pancreatic lipase inhibitors from natural sources: Unexplored potential. Drug Discov Today 2007;12:879-89.
22. Shimoda H, Seki E, Aitani M. Inhibitory effect of green coffee bean extract on fat accumulation and body weight gain in mice. BMC Complement Altern Med 2006;6:9-13.
23. Ellrichmann M, Kapelle M, Ritter PR, Holst JJ, Herzig KH, Schmidt WE, et al. Orlistat inhibition of intestinal lipase acutely increases appetite and attenuates postprandial glucagon-like peptide-1- (7-36)-amide-1, cholecystokinin, and peptide YY concentrations. J Clin Endocrinol Metab 2008;93:3995-8.
24. Nakai M, Fukui Y, Asami S, Toyoda-Ono Y, Iwashita T, Shibata H, et al. Inhibitory effects of oolong tea polyphenols on pancreatic lipase in vitro. J Agric Food Chem 2005;53:4593-8.
25. Li F, Li W, Fu H, Zhang Q, Koike K. Pancreatic lipase-inhibiting triterpenoid saponins from fruits of Acanthopanax senticosus. Chem Pharm Bull (Tokyo) 2007;55:1087-9.
26. Fiser A. Template-based protein structure modeling. Methods Mol Biol 2010;673:73-94.
27. Fernandez-Fuentes N, Madrid-Aliste CJ, Rai BK, Fajardo JE, Fiser A. M4T: A comparative protein structure modeling server. Nucleic Acids Res 2007;35:W363-8.
28. Rajeswari R, Umadevi M, Rahale S, Pushpa R, Selvavenkadesh S, Kumar KP, et al. Aloe vera: The miracle its medicinal and traditional uses in India. J Pharmacogn Phytochem 2012;1:118-24.
Statistics
191 Views | 64 Downloads
Citatons
How to Cite
DISALVA X, SHARANYA M, and MAHENDRAN RADHA. “ALOE VERA: AN ASSURED WEIGHT LOSS DIET – AN APPROACH TOWARD IMPROVING THE JUICE PALATABILITY AND IN SILICO ANALYSIS”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 12, no. 6, May 2019, pp. 331-6, doi:10.22159/ajpcr.2019.v12i6.32380.
Section
Original Article(s)