THE COMBINED EFFECT OF DEXAMETHASONE AND BACILLUS CALMETTE–GUÉRIN ON THE NEUROBEHAVIORAL ASPECT IN MALE MICE (MUS MUSCULUS)

  • ABDELKRIM HAOULI Department of Biology, Applied Neuroendocrinology Laboratory, Faculty of Sciences, University Badji Mokhtar, Sidi Amar, Annaba, Algeria.
  • SAMIR DJEMLI Department of Biology, Applied Neuroendocrinology Laboratory, Faculty of Sciences, University Badji Mokhtar, Sidi Amar, Annaba, Algeria.
  • ABDELKRIM TAHRAOUI Department of Biology, Applied Neuroendocrinology Laboratory, Faculty of Sciences, University Badji Mokhtar, Sidi Amar, Annaba, Algeria.

Abstract

Objective: Our study aims to evaluate the combined effect of Bacille Calmette–Guérin (BCG) and dexamethasone (DEX) on male mice undergoing behavioral testing (forced swimming test, elevated plus maze, tail suspension test, and sucrose intake). An intraperitoneal injection of 0.2 ml/mg of BCG and 0.1 ml/mg of DEX body weight was administered after all behavioral tests were applied.


Methods: This study is based on the distribution of 15 male mice in three groups: Controls, DEX, and DEX+BCG. These mice underwent behavioral tests.


Results: The result after administration of DEX and BCG was found after 10 days. We observed an increase in locomotors activity with some degree of anxiety.


Conclusion: This allowed us to conclude that the combination of DEX+BCG seems to play a depressinogenic effect that will develop to become antidepressive.

Keywords: Mice, Bacille Calmette–Guérin, Dexamethasone, Behavioral, Depressinogenic, Antidepressive

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ABDELKRIM HAOULI, SAMIR DJEMLI, and ABDELKRIM TAHRAOUI. “THE COMBINED EFFECT OF DEXAMETHASONE AND BACILLUS CALMETTE–GUÉRIN ON THE NEUROBEHAVIORAL ASPECT IN MALE MICE (MUS MUSCULUS)”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 12, no. 8, June 2019, pp. 195-01, https://innovareacademics.in/journals/index.php/ajpcr/article/view/32609.
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