HISTOMORPHOMETRY OF THE THYROID GLAND IN RAT AFTER LITHIUM ADMINISTRATION

  • Dalvinder Singh Jamia Millia Islamia ( A Central University) Jamia Nagar, New Delhi-110025
  • Mahindra Nagar Professor & Head Department of Anatomy UCMS & GTB Hospital Shahdara, Delhi-110095
  • Ram Prakash Professor Department of Anatomy UCMS & GTB Hospital Shahdara, Delhi-110095

Abstract

Objectives: Lithium carbonate is being used for various psychiatric and non-psychiatric illness, and has been recently observed to produce goitre and in some cases thyrotoxicosis. Most of these are based on clinical and laboratory observations. The present study was undertaken to observe the histomorphological changes in the thyroid gland after administration of lithium carbonate in rats.

Methods: Adult Wistar rats (150-250 gms) were administered 40mg/kg body weight/day lithium carbonate by intraperitoneal injection for thirty days. Controls were maintained. The animals were sacrificed fifteen hours after the last injection. Thyroids were removed and processed for routine histological studies.

Results: The size of the follicles were increased and showed an abundance of colloid. Statistically significant decrease in the epithelial cell size was also observed.

Conclusion: The present study is probably suggestive of development of hypothyroidism after chronic administration of lithium carbonate in albino rats. So, it is advised that patients on lithium therapy should be periodically evaluated for thyroid function.

Keywords: Thyroid gland, Lithium, Rat.

Author Biography

Dalvinder Singh, Jamia Millia Islamia ( A Central University) Jamia Nagar, New Delhi-110025

Associate Professor & Incharge

Department of Anatomy

References

1. Cade J. F. J.: Lithium salts in the treatment of psychotic excitement. Medical Journal of Australia 1949; 36: 349 – 352.
2. Aydin I., Aslan I., Bahceci M. and Aydin M.: Morphologic and functional alterations of the thyroid gland in rabbits treated with lithium. Hormone and Metabolic Research 1996; 28: 323 – 325.
3. Bschor T. and Bauer M.: Thyroid gland functions in lithium treatment: Nervenarzt 1998; Mar, 69(3): 189-195.
4. Chatterjee S., Roden K. and Banerji K. Tapan : Morphological changes in some endocrine organs in rats following chronic lithium treatment. Anatomischer Anzeiger 1990; 170: 31 – 37.
5. Yassa R., Saunders A. Nastase C. and Camille Y.: Lithium induced thyroid disorders: A Prevalence study. Journal of Clinical Psychiatry 1998; 49(1): 14-16.
6. Todd J. and Jerram T.C.: Thyrotoxicosis during lithium treatment. The British Journal of Clinical Practice 1978; 32: 201-203.
7. Kontozoglou T., Mambo N.: The histopathologic features of lithium-associated thyroiditis. Human Pathology 1983; 14: 737-739
8. Mizukami Y., Michigishi T., Nonomura A., Nakamura S., Noguchi M. and Takazakura E.: Histological features of the thyroid gland in a patient with lithium induced thyrotoxicosis. Journal of Clinical Pathology 1995; 48(6): 582 – 584.
9. Shou M.: Biology and Pharmacology of the lithium ion. Pharmacological Reviews 1957; 9: 17-58.
10. Corbett C. E.: Uso de litio. In Farmacodinamica, 7 Ed. Editora Guanabara Koogan. Rio de Janeiro – RJ, 1982, 23 p.
11. Schreiber V., Rohacova J. and Pribyl T.: Endocrine changes after chronic lithium carbonate administration in rats. Physiologia Bohemoslovaca 1971; Vol 20: 249 – 259.
12. Hansen H. E., Pedersen B. and Amdisen A.: Renal function and plasma aldosterone during acute lithium intoxication. Acta Med Scand, Stockholm 1979; 205: 593 – 597.
13. Jacobsen N. O., Olesen O. V., Thomsen K., Ottosen P. D. and Olsen S.: Early changes in renal distal convoluted tubule and collecting ducts of lithium treated rats. Laboratory Investigation, New York 1982; .46: 298 – 305.
14. Hestbech J., Hansen H. E., Amdisen A. and Olsen S.: Chronic renal lesions following long term treatment with lithium. Kidney International 1977; 12: 205 – 213.
15. Carl E. Heltne and Dwayne A. Ollerich: Morphometric and electron microscopic studies of goitre induced by lithium in the rat. American Journal of Anatomy 1972; 136: 297 – 304.
16. Dhawan D., Sharma R., Sharma R. R. and Dash R. J.: Serum thyroxine and triiodothyronine concentrations in rats receiving lithium carbonate. Hormone and Metabolic Research 1985; 17: 109 – 110.
17. Berens S. C., Wolff J. and Murphy D. L.: Lithium concentration by the thyroid. Endocrinology 1970; 87: 1085.
18. Transbol I., Christiansen C. and Baastrup P.: Endocrine effects of lithium, 1. Hypothyroidism prevalence in long-term treated patients. Acta Endocrinology 1978; 87:759-767.
19. Candy J.: Severe hypothyroidism – an early complication of lithium therapy. British Medical Journal. 1972; 3: 277.
20. Shopsin B., Shenkman L., Blum M. and Hollander C. S.: Iodine and lithium-induced hypothyroidism. Documentation of synergism. The American Journal of Medicine 1973; Nov, Vol 55: 695 – 699.
21. Brownlie B. E. W.,Chambers S. T.,Sadler W. A. and Donald R. A. : Lithium associated thyroid disease – A report of 14 cases of hypothyroidism and 4 cases of thyrotoxicosis. Australian and New Zealand Journal of Medicine 1976; 6: 223 – 229.
22. Goran Lindstedt, Lars-Ake Nilsson, Jan Walinder, Annika Skott and Rolf Ohmman: On the prevalence, diagnosis and management of lithium-induced hypothyroidism in psychiatric patients. British Journal of Psychiatry 1977; 130: 452 – 458.
Statistics
262 Views | 409 Downloads
How to Cite
Singh, D., M. Nagar, and R. Prakash. “HISTOMORPHOMETRY OF THE THYROID GLAND IN RAT AFTER LITHIUM ADMINISTRATION”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 8, no. 1, Jan. 2015, pp. 339-41, https://innovareacademics.in/journals/index.php/ajpcr/article/view/3288.
Section
Original Article(s)