• Mohib Khan
  • Rana Tabassum


Objective: The aim of the present investigation was to evaluate the anti-inflammatory activity of Ficus dalhousiae Miq roots ethanolic extract (FDREE)
in Wistar albino rats using carrageenan and formalin induced paw edema model.
Methods: Plant material was collected from Tirupati, A.P, during the month of June 2014.The roots were made free from dust and foreign material and
dried under shade at room temperature. After a week, the roots were powdered and passed through a sieve. The powder was weighed (500 g) and
was extracted by successive solvent extraction process. The total yield of the ethanolic extract was 17.6%. Phytochemical screening was carried out
for the detection of the phytoconstituents by simple qualitative methods. The dosing was designed as per the acute toxicity study reported earlier.The
anti-inflammatory activity was performed by carrageenan and formalin induced paw edema model at three different doses, 150 mg/kg, 300 mg/ kg
and 600 mg/kg. Wistar rats weighing (130-150 g) of either sex were used for the study.
Results: There was a significant reduction of elevated paw volume in the test groups observed in both carrageenan and formalin induced paw edema
models. The percentage inhibition of inflammation was also high in the test groups compared with the negative control.
Conclusion: FDREE exhibited anti-inflammatory activity in both acute and subacute experimental models which provides the evidence of its use as
a potent anti-inflammatory drug.

Keywords: Ficus dalhousiae roots ethanolic extract, Carrageenan, Formalin, Intraperitonial.

Author Biography



1. Vodovotz Y, Constantine G, Rubin J, Csete M, Voit EO, An G. Mechanistic simulations of inflammation: current state and future prospects. Math Biosci 2009;217(1):1-10.
2. Shock CS. Inflammation and PARP. Pharmacol Res 2005;52(1):72-82.
3. Chizzolini C. Update on pathophysiology of scleroderma with special reference to immunoinflammatory events. Ann Med 2007;39(1):42-53.
4. Serhan CN, Oliw E. Unorthodox routes to prostanoid formation: new twists in cyclooxygenase-initiated pathways. J Clin Invest 2001;107(12):1481-9.
5. Xiao J, Jiang X, Chen X. Antibacterial, anti-inflammatory and diuretic effect of flavanoids from Marchantia convoluta. Afr J Tradit Complementary Altern Med 2005;2:244-52.
6. Simoes CM, Schenkel EP, Gosmann, G, Mello JC, Mentz LA. Pharmacognosy of Plant Medicaments, 5th ed. Porto Alegre, Brazil: Editora da UFRGS; 2004. p. 424.
7. Rimbach G, Melchin M, Moehring J, Wagner AE. Polyphenols from cocoa and vascular health-a critical review. Int J Mol Sci 2009;10(10):4290-309.
8. Balunas MJ, Kinghorn AD. Drug discovery from medicinal plants. Life Sci 2005;78:431-41.
9. Khare CP. Indian Medicinal Plants an Illustrated Dictionary. New York, NY: Springer Science and Business Media; 2007. p. 266.
10. Deore SL, Khadabadi SS, Baviskar BA. Pharmacognosy and Phytochemistry. A Comprehensive Approach. Hyderabad: Pharma Med Press; 2014. p. 481.
11. Ghori SS, Khan M, Khan SA, Baig MD. Antihyperglycaemic effect of Ficus dalhousiae Miq leaf ethanolic extract in alloxan - Induced diabetic rats. Int J Pharm Pharm Sci 2014;6(9):132-6.
12. Ghori SS, Khan M, Quereshi MS, Mohiuddin M, Muqtadir MA. Gastroprotective effects of Ficus dalhousiae roots Miq ethanolic extract in indomethacin and cold restraint stress induced ulcers. Int Res J Pharm 2014;5(9):721-5.
13. Sheth UK, Dadkar NK, Kamt UG. Drugs Acting on CNS, Selected Topics in Experimental Pharmacology. 1st ed. Mumbai, India: Mohanlal. B. Kothari of the Kothari Book Depot; 1972.
14. Brownlee G. Effect of deoxycortone and ascorbic acid on formaldehyde-induced arthritis in normal and adrenalectomized rats. Lancet 1950;1:157-9.
15. Kumar V, Abbas AK, Faust N. Chronic inflammation, In: Robbins and Cotran Pathology. 7th ed. Rio de Janeiro, Brazil: Elsevier Publication; 2005. p. 49-89.
16. Dannhardt G, Kiefer W. Cyclooxygenase inhibitors – current status and future prospects. Eur J Med Chem 2001;36(2):109-26.
17. Selvi SV, Bhaskar A. Characterization of anti-inflammatory activities and antinociceptive effects of papaverine from Sauropus androgynus (L.) Merr. Glob J Pharmacol 2012;6(3):186-92.
18. Kumari TS, Lincy MP, Muthukumarasamy S, Mohan VR. Anti‑inflammatory activity of sarcostemma secamone bennet whole plant against carrageenan induced paw edema. Biosci Discov 2012;3(3):288‑91.
19. Vinegar R, Schreiber W, Hugo R. Biphasic development of carrageenin edema in rats. J Pharmacol Exp Ther 1969;166(1):96-103.
20. Namita P, Mukesh R, Tirath K. Evaluation of anti-inflammatory potential of Kigelia pinnata leaf extract in wistar rats. Asian J Pharm Clin Res 2012;5(1):95.
21. Ananthi T, Chitra M. Screening of in vitro anti-inflammatory activity of Michelia champaca Linn. flowers. Asian J Pharm Clin Res 2013;6(5):71-2.
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How to Cite
Ghori, S. S., M. Khan, and R. Tabassum. “ANTI-INFLAMMATORY ACTIVITY OF FICUS DALHOUSIAE MIQ ROOTS ETHANOLIC EXTRACT IN WISTAR ALBINO RATS”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 8, no. 1, Jan. 2015, pp. 117-9,
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