Effects EFFECTS OF PUMPKIN (CUCURBITA MOSCHATA DURCH) SEED POWDER ON BLOOD GLUCOSE LEVEL IN STREPTOZOTOCIN-INDUCED MICE
Objective: The aim of this research is to evaluate the antidiabetic effect of pumpkin seed powder in streptozotocin (STZ)-induced diabetic mice.
Methods: Pumpkin seed was used in seed powder suspension form and then evaluate the phytochemical screening and induced diabetic mice using STZ.
Results: The phytochemical screening showed that pumpkin seed powder has various of phytochemical compounds. The pumpkin seed powder (dose level 100, 150, and 200 mg/kg bw) showed a significant reduction of blood glucose.
Conclusions: Pumpkin seed powder significantly decreases blood glucose level in STZ-induced mice.
2. Ijaola TO, Osunkiyesi AA, Taiwo AA, Oseni OA, Lanrelyanda YA, Ajayi JO, et al. Antidiabetic effect of Ipomoea batatas in normal and alloxan induced diabetic rats. IOSR J Appl Chem 2014;7:16-25.
3. Giacco R, Giulio BD, Vitale M, Cozzoliono R. Functional foods: Can food technology help in the prevention and treatmen of diabetes. Food Nutr Sci 2013;4:827-37.
4. Marbun N. Comparison of Blood Glucose Levels Decrease Effectiveness of Pumpkin Flesh and Seeds toward Diabetic Mice. Thesis, Faculty of Pharmacy, University of Sumatera Utara No. 1-106; 2017.
5. Rumanti RM. Characterization of Simplicia and Chromatographic Analysis of Active Extract Lotus (Nelumbo nucifera Gaertn) which can Reduce Blood Glucose in Mice. Thesis, Faculty of Pharmacy, University of Sumatera Utara No. 1-104; 2017.
6. Lal VK, Gupta PP, Awanish P. Hypoglycemic effect of Kyllinga triceps in STZ induced diabetic rats. J Diabetes Metab 2012;3:1-3.
7. McCarty MF. Nutraceutical resources for diabetes prevention an update. Med Hypotheses 2005;64:151-8.
8. Teugwa CM, Boudjeko T, Tchinda BT, Mejiato PC, Zofou D. Anti-hyperglycaemic globulins from selected Cucurbitaceae seeds used as antidiabetic medicinal plants in Africa. BMC Complement Altern Med 2013;13:63.
9. Xiaotian C, Changyin W, Jianxin C, Gbago O, Yuanda S. Antibacterial activity of lotus leaves (Nelumbo nucifera) against food-borne pathogens. Am J Biochem Biotechnol 2015;11:11-6.
10. Ditjen PO. Farmakope Indonesia. Vol. 4. Jakarta: Depkes RI; 1995. p. 896-8.
11. Depkes RI. Materia Medika. Vol. 6. Jakarta: Ditjen POM; 1995. p. 297 307.
12. Farnsworth NR. Biological and phytochemical screening of plants. J Pharm Sci 1966;55:225-76.
13. Bharathi TR, Prakash HS. Comparative evaluation of antidiabetic and antioxidant potency of different extracts obtained from Memecylon species. Int J Pharm Pharm Sci 2017;9:187-91.
14. Priyanka P, Singh R. A systematic review on Indian floral biodiversity as eminent reserves fpr alternative treatment strategy of diabates mellitus. Int J Pharm Pharm Sci 2016;8:10-9.
15. Kar MK, Swain TR, Mishra SK. Antidiabetic activity of Clerodendrum serratum moon leaves un streptozotocin-induced diabetic rats. Asian J Pharm Clin Res 2014;7:260-3.
16. Mujic A, Grdovic N, Mujic I, Mihailovic M, Zivkovic J, Poznanovic G, et al. Antioxidative effects of phenolic extracts from chestnut leaves, catkins and spiny burs in streptozotocin-treated rat pancreatic ?-cells. Food Chem 2011;125:841-9.
17. Acosta-Patiño JL, Jiménez-Balderas E, Juárez-Oropeza MA, Díaz-Zagoya JC. Hypoglycemic action of Cucurbita ficifolia on Type 2 diabetic patients with moderately high blood glucose levels. J Ethnopharmacol 2001;7799-101.
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