ATOMIC ABSORPTION SPECTROPHOTOMETER – A VERSATILE TOOL FOR THE ESTIMATION OF NICKEL CONTENT IN DRONEDARONE

  • VASAVI DEVI DASARI JNTUA, Ananthapuramu, Andhra Pradesh, India.
  • SWARNALATHA DUGASANI Department of Pharmaceutical Sciences, Annamacharya College of Pharmacy, Rajampeta, Andhra Pradesh, India.
  • VENKATASUBBA REDDY GOPIREDDY Department of Chemistry, Jawaharlal Nehru Technological University Anantapur College of Engineering, Pulivendula, Andhra Pradesh, India.

Abstract

Objective: The present investigation is to develop a validated analytical method for the determination of nickel content in dronedarone hydrochloride bulk drug by atomic absorption spectrophotometer (AAS).


Methods: Samples were analyzed after a preparation of sample solution by dissolving in suitable diluents of nitric acid and perchloric acid. In the present method, AAS with 0.2 nm slit width, nickel hollow cathode lamp with a wavelength of 232 nm has been employed.


Results: The system suitability parameters were performed to assess the system performance. The limit of detection and limit of quantification (LOQ) were found to be 0.051 ppm and 0.15 ppm, respectively. The percentage recovery at LOQ, 50%, 100%, and 150% levels of nickel in dronedarone was found to be 95.55, 109.33, 96, and 97.55, respectively.


Conclusion: With the developed method, the nickel content in dronedarone bulk sample was found to be 3.0 ppm.

Keywords: Dronedarone, Nickel, \Atomic absorption spectrophotometer, Validation

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How to Cite
VASAVI DEVI DASARI, SWARNALATHA DUGASANI, and VENKATASUBBA REDDY GOPIREDDY. “ATOMIC ABSORPTION SPECTROPHOTOMETER – A VERSATILE TOOL FOR THE ESTIMATION OF NICKEL CONTENT IN DRONEDARONE”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 12, no. 8, June 2019, pp. 187-90, https://innovareacademics.in/journals/index.php/ajpcr/article/view/33921.
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