ARSENIC: A HARMFUL AND DESECRATE COMPOUND FOR THE HUMANS

  • SURESH CHANDRA Department of Pharmacy, Pranveer Singh Institute of Technology, Kanpur, Uttar Pradesh, India.
  • ARYENDU KUMAR SAINI Department of Pharmacy, Pranveer Singh Institute of Technology, Kanpur, Uttar Pradesh, India.
  • AKASH KUMAR GUPTA Department of Pharmacy, Rajiv Gandhi Proudyogiki Vishwavidyalaya, Bhopal, Madhya Pradesh, India.

Abstract

Arsenic toxicity has become a burgeoning concern as several millions of people are exposed to this chemical through drinking water contamination by arsenic remains a major public health problem. Acute and chronic arsenic exposure through drinking water has been reported in many countries of the world, where a large proportion of drinking water is contaminated with high concentrations of arsenic. As contamination in groundwater has been found in more than 105 countries around the world, it has become the worldwide health problem as several millions of people are exposed to this toxicant. Arsenic contamination of different countries includes Bangladesh, India, Vietnam, Nepal, Thailand, and Chili is the major affected countries where inorganic arsenic in the groundwater with high concentration is seen. Arsenic is one of the most toxic metals which is originated from the natural environment. The catastrophe is that the majority of human arsenic toxicity is from polluted drinking water rather than agricultural sources (fertilizers or pesticides). The different areas across the Gangetic plains in Nepal and India also recently reported being affected by the arsenic. The hippocampus is a part of the limbic system that is crucial to memory function and spatial navigation. Hippocampus lesions in humans produce devastating impairments in declarative memory, and similar results have been seen in non-human primates with hippocampus neurobehavioral disorders.

Keywords: Heavy metal, Neurotoxicity, Poisoning, Pollution

Author Biography

SURESH CHANDRA, Department of Pharmacy, Pranveer Singh Institute of Technology, Kanpur, Uttar Pradesh, India.

Research Scholar, Pharmacy Department, Pranveer Singh Institute of Technology

References

1. Velu V. Efficacy of microdoses potentized homeopathic drug, arsenicum album induced by arsenic trioxide in zebrafish (Danio rerio) a FTIR study in gills. Int J Pharm Pharm Sci 2017;9:48-51.
2. Hanchett S, Nahar Q, Van Agthoven A, Geers C, Rezvi MD. Increasing awareness of arsenic in Bangladesh: Lessons from a public education programme. Health Policy Plan 2002;17:393-401.
3. Rahman MM, Chowdhury UK, Mukherjee SC, Mondal BK, Paul K, Lodh D, et al. Chronic arsenic toxicity in Bangladesh and West Bengal, India a review and commentary. J Toxicol Clin Toxicol 2001;39:683-700.
4. Ghosh P, Roy C, Das NK, Sengupta SR. Epidemiology and prevention of chronic arsenicosis: An Indian perspective. Indian J Dermatol Venereol Leprol 2008;74:582-93.
5. Spallholz JE, Mallory Boylan L, Rhaman MM. Environmental hypothesis: Is poor dietary selenium intake an underlying factor for arsenicosis and cancer in Bangladesh and West Bengal, India? Sci Total Environ 2004;323:21-32.
6. Pastorelli AA, Baldini M, Stacchini P, Baldini G, Morelli S, Sagratella E, et al. Human exposure to lead, cadmium and mercury through fish and seafood product consumption in Italy: A pilot evaluation. Food Addit Contam Part A Chem Anal Control Expo Risk Assess 2012;29:1913-21.
7. Llobet JM, Falcó G, Bocio A, Domingo JL. Human exposure to polychlorinated naphthalenes through the consumption of edible marine species. Chemosphere 2007;66:1107-13.
8. Hackenmueller SA, Strathmann FG. Total arsenic screening prior to fractionation enhances clinical utility and test utilization in the assessment of arsenic toxicity. Am J Clin Pathol 2014;142:184-9.
9. Komorowicz I, Bara?kiewicz D. Arsenic and its speciation in water samples by high performance liquid chromatography inductively coupled plasma mass spectrometry last decade review. Talanta 2011;84:247-61.
10. Castillo A, Roig-Navarro AF, Pozo OJ. Capabilities of microbore columns coupled to inductively coupled plasma mass spectrometry in speciation of arsenic and selenium. J Chromatogr A 2008;1202:132-7.
11. B’Hymer C, Caruso JA. Arsenic and its speciation analysis using high-performance performance liquid chromatography and inductively coupled plasma mass spectrometry. J Chromatogr A 2004;1045:1-3.
12. Benramdane L, Bressolle F, Vallon JJ. Arsenic speciation in humans and food products: A review. J Chromatogr Sci 1999;37:330-44.
13. Mahajan L, Verma PK, Raina R, Sood S. Toxic effects of imidacloprid combined with arsenic: Oxidative stress in rat liver. Toxicol Ind Health 2018;34:726-35.
14. Brayer AF, Callahan CM, Wax PM. Acute arsenic poisoning from ingestion of “snakes”. Pediatr Emerg Care 1997;13:394-6.
15. Anawar HM, Akai J, Mostofa KM, Safiullah S, Tareq SM. Arsenic poisoning in groundwater: Health risk and geochemical sources in Bangladesh. Environ Int 2002;27:597-604.
16. Wasserman GA, Liu X, Parvez F, Ahsan H, Factor-Litvak P, van Geen A, et al. Water arsenic exposure and children’s intellectual function in Araihazar, Bangladesh. Environ Health Perspect 2004;112:1329-33.
17. Carrizales L. The effects of sodium arsenite exposure on behavioral parameters in the rat. Brain Res 2010;1:21-2.
18. Chen U. Health effects of arsenic longitudinal study. J Expo Sci Environ Epidemiol 2004;16:195-204.
19. Cen Z. Reliability of a commercial kit to test groundwater for arsenic in Bangladesh. Environ Sci 2004;21:1-11.
20. Ambasta SK, Kumari S, Sinha SK. Anticlastogenic of Tinospora cordifolia stem extract against arsenic genotoxicity in Mus musculus bone marrow erythrocytes using micronucleus assay. Int J Pharm Pharm Sci 2017;9:260-4.
21. Zhou DX. Investigation of chronic arsenic poisoning caused by high arsenic coal pollution. Zhonghua Yu Fang Yi Xue Za Zhi 1993;27:147-50.
22. Shih YH, Islam T, Hore SK, Sarwar G, Shahriar MH, Yunus M, et al. Associations between prenatal arsenic exposure with adverse pregnancy outcome and child mortality. Environ Res 2017;158:456-61.
23. Rahman A, Persson LÅ, Nermell B, El Arifeen S, Ekström EC, Smith AH, et al. Arsenic exposure and risk of spontaneous abortion, stillbirth, and infant mortality. Epidemiology 2010;21:797-804.
24. von Ehrenstein OS, Mazumder DN, Hira-Smith M, Ghosh N, Yuan Y, Windham G, et al. Pregnancy outcomes, infant mortality, and arsenic in drinking water in West Bengal, India. Am J Epidemiol 2006;163:662-9.
25. Yoshida T, Yamauchi H, Fan Sun G. Chronic health effects in people exposed to arsenic via the drinking water: Dose-response relationships in review. Toxicol Appl Pharmacol 2004;198:243-52.
26. Yu HS, Lee CH, Chen GS. Peripheral vascular diseases resulting from chronic arsenical poisoning. J Dermatol 2002;29:123-30.
27. Tseng WP. Effects and dose response relationships of skin cancer and Blackfoot disease with arsenic. Environ Health Perspect 1977;19:109-19.
28. Yang CY. Does arsenic exposure increase the risk of development of peripheral vascular diseases in humans? J Toxicol Environ Health A 2006;69:1797-804.
29. Liu J. Chronic arsenic poisoning from burning high-arsenic-containing coal in Guizhou. N Engl J Med 2000;1:100.
30. Gorby MS. Arsenic poisoning. West J Med 1988;149:308-15.
31. Montelescaut E, Vermeersch V, Commandeur D, Huynh S, des Deserts MD, Sapin J, et al. Acute arsenic poisoning. Ann Biol Clin (Paris) 2014;72:735-8.
32. Vahidnia A, van der Voet GB, de Wolff FA. Arsenic neurotoxicity--a review. Hum Exp Toxicol 2007;26:823-32.
33. Thomas DJ, Styblo M, Lin S. The cellular metabolism and systemic toxicity of arsenic. Toxicol Appl Pharmacol 2001;176:127-44.
34. Cohen SM, Arnold LL, Eldan M, Lewis AS, Beck BD. Methylated arsenicals: The implications of metabolism and carcinogenicity studies in rodents to human risk assessment. Crit Rev Toxicol 2006;36:99-133.
35. Dopp E, Hartmann LM, Florea AM, von Recklinghausen U, Pieper R, Shokouhi B, et al. Uptake of inorganic and organic derivatives of arsenic associated with induced cytotoxic and genotoxic effects in Chinese hamster ovary (CHO) cells. Toxicol Appl Pharmacol 2004;201:156-65.
36. Hirano S, Kobayashi Y, Cui X, Kanno S, Hayakawa T, Shraim A, et al. The accumulation and toxicity of methylated arsenicals in endothelial cells: Important roles of Thiol compounds. Toxicol Appl Pharmacol 2004;198:458-67.
37. Aposhian HV, Zakharyan RA, Avram MD, Kopplin MJ, Wollenberg ML. Oxidation and detoxification of trivalent arsenic species. Toxicol Appl Pharmacol 2003;193:1-8.
38. Shen J, Wanibuchi H, Waalkes MP, Salim EI, Kinoshita A, Yoshida K, et al. A comparative study of the sub-chronic toxic effects of three organic arsenical compounds on the urothelium in F344 rats; gender-based differences in response. Toxicol Appl Pharmacol 2006;210:171-80.
39. Shen J, Wanibuchi H, Salim EI, Wei M, Doi K, Yoshida K, et al. Induction of glutathione S-transferase placental form positive fociin liver and epithelial hyperplasia in urinary bladder, but no tumor development in male Fischer 344 rats treated with monomethylarsonic acid for 104 weeks. Toxicol Appl Pharmacol 2003;193:335-45.
40. Chakraborti D, Rahman MM, Paul K, Chowdhury UK, Sengupta MK, Lodh D, et al. Arsenic calamity in the Indian subcontinent what lessons have been learned? Talanta 2002;58:3-22.
41. Das D, Chatterjee A, Mandal BK, Samanta G, Chakraborti D, Chanda B, et al. Arsenic in ground water in six districts of West Bengal, India: The biggest arsenic calamity in the world. Part 2. Arsenic concentration in drinking water, hair, nails, urine, skin-scale and liver tissue (biopsy) of the affected people. Analyst 1995;120:917-24.
42. Bhadauria S, Flora SJ. Response of arsenic-induced oxidative stress, DNA damage, and metal imbalance to combined administration of DMSA and monoisoamyl-DMSA during chronic arsenic poisoning in rats. Cell Biol Toxicol 2007;23:91-104.
43. Abu-taweel GM. Curcumin attenuates lead (Pb) induced neurobehavioral and neurobiochemical dysfunction: A review. Int J Pharm Pharm Sci 2018;10:23-8.
44. Tewtrakul S, Subhadhirasakul S. Anti-allergic activity of some selected plants in the Zingiberaceae family. J Ethnopharmacol 2007;109:535-8.
45. Taylor V, Goodale B, Raab A, Schwerdtle T, Reimer K, Conklin S, et al. Human exposure to organic arsenic species from seafood. Sci Total Environ 2017;580:266-82.
46. Molin M, Ydersbond TA, Ulven SM, Holck M, Dahl L, Sloth JJ, et al. Major and minor arsenic compounds accounting for the total urinary excretion of arsenic following intake of blue mussels (Mytilus edulis): A controlled human study. Food Chem Toxicol 2012;50:2462-72.
47. Lai VW, Sun Y, Ting E, Cullen WR, Reimer KJ. Arsenic speciation in human urine: Are we all the same? Toxicol Appl Pharmacol 2004;198:297-306.
48. Moreda-Piñeiro A, Peña-Vázquez E, Hermelo-Herbello P, Bermejo- Barrera P, Moreda-Piñeiro J, Alonso-Rodríguez E, et al. Matrix solid-phase dispersion as a sample pretreatment for the speciation of arsenic in seafood products. Anal Chem 2008;80:9272-8.
49. Hsieh YJ, Jiang SJ. Application of HPLC-ICP-MS and HPLC-ESI-MS procedures for arsenic speciation in seaweeds. J Agric Food Chem 2012;60:2083-9.
50. Rahman M, Sohel N, Hore SK, Yunus M, Bhuiya A, Streatfield PK, et al. Prenatal arsenic exposure and drowning among children in Bangladesh. Glob Health Action 2015;8:28702.
51. Marchettini P, Lacerenza M, Mauri E, Marangoni C. Painful peripheral neuropathies. Curr Neuropharmacol 2006;4:175-81.
52. Hilz MJ, Marthol H, Neundörfer B. Diabetic somatic polyneuropathy. Pathogenesis, clinical manifestations and therapeutic concepts. Fortschr Neurol Psychiatr 2000;68:278-88.
53. Chen Y, Parvez F, Gamble M, Islam T, Ahmed A, Argos M, et al. Arsenic exposure at low-to-moderate levels and skin lesions, arsenic metabolism, neurological functions, and biomarkers for respiratory and cardiovascular diseases: Review of recent findings from the health effects of arsenic longitudinal study (HEALS) in Bangladesh. Toxicol Appl Pharmacol 2009;239:184-92.
54. Yunus M, Sohel N, Hore SK, Rahman M. Arsenic exposure and adverse health effects: A review of recent findings from arsenic and health studies in Matlab, Bangladesh. Kaohsiung J Med Sci 2011;27:371-6.
55. Rodríguez VM, Jiménez-Capdeville ME, Giordano M. The effects of arsenic exposure on the nervous system. Toxicol Lett 2003;145:1-8.
56. Si?czuk-Walczak H. Nervous system disorders induced by occupational exposure to arsenic and its inorganic compounds: A literature review. Med Pr 2009;60:519-22.
57. Halatek T, Sinczuk-Walczak H, Rabieh S, Wasowicz W. Association between occupational exposure to arsenic and neurological, respiratory and renal effects. Toxicol Appl Pharmacol 2009;239:193-9.
58. Rossy KM, Janusz CA, Schwartz RA. Cryptic exposure to arsenic. Indian J Dermatol Venereol Leprol 2005;71:230-5.
59. Tyler CR, Allan AM. The effects of arsenic exposure on neurological and cognitive dysfunction in human and rodent studies: A review. Curr Environ Health Rep 2014;1:132-47.
60. Davey JC, Bodwell JE, Gosse JA, Hamilton JW. Arsenic as an endocrine disruptor: Effects of arsenic on estrogen receptor-mediated gene expression in vivo and in cell culture. Toxicol Sci 2007;98:75-86.
61. Kannan GM, Tripathi N, Dube SN, Gupta M, Flora SJ. Toxic effects of arsenic (III) on some hematopoietic and central nervous system variables in rats and guinea pigs. J Toxicol Clin Toxicol 2001;39:675-82.
62. Bolt HM. Current developments in toxicological research on arsenic. EXCLI J 2013;12:64-74.
63. Hong YS, Song KH, Chung JY. Health effects of chronic arsenic exposure. J Prev Med Public Health 2014;47:245-52.
64. Liu H, Song N. Molecular mechanism of adult neurogenesis and its association with human brain diseases. J Cent Nerv Syst Dis 2016;8:5-11.
65. Grote HE, Hannan AJ. Regulators of adult neurogenesis in the healthy and diseased brain. Clin Exp Pharmacol Physiol 2007;34:533-45.
66. Curtis MA, Low VF, Faull RL. Neurogenesis and progenitor cells in the adult human brain: A comparison between hippocampal and subventricular progenitor proliferation. Dev Neurobiol 2012;72:990-1005.
67. Brandt MD, Storch A. Neurogenesis in the adult brain: From bench to bedside? Fortschr Neurol Psychiatr 2008;76:517-29.
68. Low VF, Dragunow M, Tippett LJ, Faull RL, Curtis MA. No change in progenitor cell proliferation in the hippocampus in Huntington’s disease. Neuroscience 2011;199:577-88.
69. Gil-Mohapel J, Simpson JM, Ghilan M, Christie BR. Neurogenesis in Huntington’s disease: Can studying adult neurogenesis lead to the development of new therapeutic strategies? Brain Res 2011;1406:84-105.
70. Goggin SL, Labrecque MT, Allan AM. Perinatal exposure to 50 ppb sodium arsenate induces hypothalamic-pituitary-adrenal axis dysregulation in male C57BL/6 mice. Neurotoxicology 2012;33:1338-45.
71. Shoener JA, Baig R, Page KC. Prenatal exposure to dexamethasone alters hippocampal drive on hypothalamic-pituitary-adrenal axis activity in adult male rats. Am J Physiol Regul Integr Comp Physiol 2006;290:R1366-73.
72. Ahmad SA, Khan MH, Haque M. Arsenic contamination in groundwater in Bangladesh: Implications and challenges for healthcare policy. Risk Manag Healthc Policy 2018;11:251-61.
73. Atoum M, Alzoughool F. Vitamin D and breast cancer: Latest evidence and future steps. Breast Cancer (Auckl) 2017;11:1178223417749816.
74. Holick MF. Vitamin D: A millenium perspective. J Cell Biochem 2003;88:296-307.
75. Hosain M. Sustainability of arsenic mitigation interventions an evaluation of different alternative safe drinking water options provided in Matlab, an arsenic hot spot in Bangladesh. Front Environ Sci 2015;1:1-3.
76. Jiang JQ, Ashekuzzaman SM, Jiang A, Sharifuzzaman SM, Chowdhury SR. Arsenic contaminated groundwater and its treatment options in Bangladesh. Int J Environ Res Public Health 2012;10:18-46.
77. Shankar S, Shanker U, Shikha. Arsenic contamination of groundwater: A review of sources, prevalence, health risks, and strategies for mitigation. ScientificWorldJournal 2014;2014:304524.
78. Randall PM. Arsenic encapsulation using Portland cement with ferrous sulfate/lime and terra-bond™ technologies microcharacterization and leaching studies. Sci Total Environ 2012;420:300-12.
79. Moloudi K, Neshasteriz A, Hosseini A, Eyvazzadeh N, Shomali M, Eynali S, et al. Synergistic effects of arsenic trioxide and radiation: Triggering the intrinsic pathway of apoptosis Iran Biomed J 2017;21:330-7.
80. Poon IK, Hulett MD, Parish CR. Molecular mechanisms of late apoptotic/necrotic cell clearance. Cell Death Differ 2010;17:381-97.
81. Ratnaike RN. Acute and chronic arsenic toxicity. Postgrad Med J 2003;79:391-6.
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SURESH CHANDRA, ARYENDU KUMAR SAINI, and AKASH KUMAR GUPTA. “ARSENIC: A HARMFUL AND DESECRATE COMPOUND FOR THE HUMANS”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 12, no. 8, June 2019, pp. 24-29, https://innovareacademics.in/journals/index.php/ajpcr/article/view/34004.
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