• GAGANDEEP SINGH Department of Pharmaceutical Sciences, Guru Nanak Dev University, Amritsar, Punjab, India.
  • NAVJOT SINGH Department of Pharmaceutical Sciences, Guru Nanak Dev University, Amritsar, Punjab, India.
  • RANDEEP KUMAR Department of Pharmaceutical Sciences, Guru Nanak Dev University, Amritsar, Punjab, India.
  • NEENA BEDI Department of Pharmaceutical Sciences, Guru Nanak Dev University, Amritsar, Punjab, India.


Objective: The present study entails the development of nevirapine (NVP)-loaded solid dispersions for improvement of solubility and in vitro profile.

Methods: Solid dispersions were prepared through blending with a hydrophilic polymer and Vitamin E tocopherol polyethylene glycol succinate (TPGS) using the solvent evaporation method. The optimized formulations were characterized by Fourier transform infrared spectroscopy, differential scanning calorimetry, X-ray diffraction, and morphological investigations by scanning electron microscopy. The optimized formulation was converted into fast dissolving tablets (FDTs) through direct compression technique and was characterized for pre- and post-compression parameters. Both amorphous dispersions and FDTs were evaluated for in vitro drug release.

Results: NVP showed pH-dependent solubility in different pH media. Above 0.002% w/v Vitamin E TPGS, a linear relationship was observed between the NVP solubility and Vitamin E TPGS concentration. According to the study, the most suitable formulation was NVP:Vitamin E TPGS (1:0.75) in 30 ml solvent with a drug release of 82.96% in 2 h. The analysis of dissolution data of optimized formulation indicated the best fitting with the Higuchi model. FDTs exhibited faster drug release of about 50% in 5 min indicating desired attributes for the immediate dosage form.

Conclusion: The present study vouches for better in vitro profile of NVP from solid dispersion based FDTs.

Keywords: Nevirapine, Vitamin E tocopherol polyethylene glycol succinate, Solid dispersion, Fast dissolving tablets


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