DEVELOPMENT AND CHARACTERIZATION OF NEVIRAPINE LOADED AMORPHOUS SOLID DISPERSIONS FOR SOLUBILITY ENHANCEMENT

  • GAGANDEEP SINGH Department of Pharmaceutical Sciences, Guru Nanak Dev University, Amritsar, Punjab, India.
  • NAVJOT SINGH Department of Pharmaceutical Sciences, Guru Nanak Dev University, Amritsar, Punjab, India.
  • RANDEEP KUMAR Department of Pharmaceutical Sciences, Guru Nanak Dev University, Amritsar, Punjab, India.
  • NEENA BEDI Department of Pharmaceutical Sciences, Guru Nanak Dev University, Amritsar, Punjab, India.

Abstract

Objective: The present study entails the development of nevirapine (NVP)-loaded solid dispersions for improvement of solubility and in vitro profile.


Methods: Solid dispersions were prepared through blending with a hydrophilic polymer and Vitamin E tocopherol polyethylene glycol succinate (TPGS) using the solvent evaporation method. The optimized formulations were characterized by Fourier transform infrared spectroscopy, differential scanning calorimetry, X-ray diffraction, and morphological investigations by scanning electron microscopy. The optimized formulation was converted into fast dissolving tablets (FDTs) through direct compression technique and was characterized for pre- and post-compression parameters. Both amorphous dispersions and FDTs were evaluated for in vitro drug release.


Results: NVP showed pH-dependent solubility in different pH media. Above 0.002% w/v Vitamin E TPGS, a linear relationship was observed between the NVP solubility and Vitamin E TPGS concentration. According to the study, the most suitable formulation was NVP:Vitamin E TPGS (1:0.75) in 30 ml solvent with a drug release of 82.96% in 2 h. The analysis of dissolution data of optimized formulation indicated the best fitting with the Higuchi model. FDTs exhibited faster drug release of about 50% in 5 min indicating desired attributes for the immediate dosage form.


Conclusion: The present study vouches for better in vitro profile of NVP from solid dispersion based FDTs.

Keywords: Nevirapine, Vitamin E tocopherol polyethylene glycol succinate, Solid dispersion, Fast dissolving tablets

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GAGANDEEP SINGH, NAVJOT SINGH, RANDEEP KUMAR, and NEENA BEDI. “DEVELOPMENT AND CHARACTERIZATION OF NEVIRAPINE LOADED AMORPHOUS SOLID DISPERSIONS FOR SOLUBILITY ENHANCEMENT”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 12, no. 8, June 2019, pp. 176-82, https://innovareacademics.in/journals/index.php/ajpcr/article/view/34097.
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