PROTECTIVE OF ETHANOLIC EXTRACT OF SAUSSUREA LAPPA AGAINST PARACETAMOL-INDUCED HEPATIC AND RENAL DAMAGE IN MALE RABBITS
Objective: The objective of our study is to investigate the effect of the ethanolic extract of Saussurea lappa against paracetamol-induced hepatorenal toxicity in male rabbits.
Methods: Eighteen male rabbits were used for this study and were divided into three groups of six rabbits each. Group 1: Rabbits were the normal (negative control), Group 2: (Positive control) Rabbits were administered paracetamol at dose 300 mg/kg body weight (B.W) for 14 day, and Group 3: Rabbits received paracetamol at dose 300 mg/kg B.W then treated with ethanolic extract of S. lappa at dose 300 mg/kg B.W for 14 day.
Results: The obtained results showed a significant decrease (p≤0.05) in B.W, red blood cells count, white blood cells count, neutrophil, total protein, and albumin with significant (p≤0.05) increase in lymphocyte, alanine aminotransferase, aspartate aminotransferase, creatinine, urea, and malondialdehyde in rabbits of positive control group, histological studies showed many pathological changes in liver and kidney when compared with negative control group. The oral administration of the ethanolic extract of S. lappa significantly protected the hepatic and kidney cells from damage, the hematological and biochemical parameters were also almost normal in extract treated rabbits compared to the control group.
Conclusion: Our study indicates that the roots of S. lappa act as antioxidant substance and have hepato and renoprotective effect against toxicity induced by paracetamol.
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