FORMULATION OPTIMIZATION AND EVALUATION OF MOUTH DISSOLVING FILM OF APREPITANT

  • ADITI D BAVISKAR Department of Pharmaceutics, Shree Sureshdada Jain Institute of Pharmaceutical Education and Research, Jamner, Maharashtra, India.
  • BARI MM Department of Pharmaceutics, Shree Sureshdada Jain Institute of Pharmaceutical Education and Research, Jamner, Maharashtra, India.
  • BARHATE SD Department of Pharmaceutics, Shree Sureshdada Jain Institute of Pharmaceutical Education and Research, Jamner, Maharashtra, India.

Abstract

Objectives: The aim of the present research is to prepare mouth dissolving film of aprepitant used in the prevention and treatment of post-operative nausea and vomiting.


Methods: The MDF was prepared using Kollicoat IR, PEG 400, and spraying technique. Formulation was optimized by central composite design. Compatibility study was carried out using Fourier-transform infrared and differential scanning calorimetry. The films were evaluated for thickness, folding endurance, weight variation, disintegration time, dissolution studies, drug content, and in vitro diffusion test.


Results: From the results, it was found that there was no drug excipient interaction. The prepared optimized batch AP2 showed disintegration time 18 sec, highest dissolution rate 101.53%, drug diffused 39.58 mg/cm2 within 10 min and also passes all the physicochemical parameters. It was concluded that plasticizer PEG 400 plays a very much important role in the preparation of aprepitant MDF.


Conclusion: MDF of aprepitant was found to be a better option in the prevention and treatment of post-operative nausea and vomiting by the way of fast onset of action for patient convenience and compliance. In the near future, the MDF market will expand very fastly to treat various diseases.

Keywords: Aprepitant, Kollicoat IR, PEG-400, Mouth Dissolving Film, Spraying Technique, Central Composite Design

References

1. Irfan M, Rabel S, Bukhtar Q. Orally disintegrating film: A modern expansion in drug delivery system. Saudi Pharm J 2016;24:537-46.
2. Ankita DC, Bhagawati ST, Udupa N. An overview on fast dissolving oral films. Asian J Pharm Technol 2015;5:129-37.
3. Venkateswarlu K. Preperation and evaluation of fast dissolving buccal thin films of bufotenin. J In Silico In Vitro Pharmacol 2016;2:1-5.
4. Deepak H, Geeta A, Kumar SL. Recent trends of fast dissolving drug delivery system-an overview of formulation technology. Pharmacophore 2013;4:1-9.
5. Vanksha K, Juber A, Shazia U. A review on fast dissolving formulation technologies. World J Pharm Pharm Sci 2015;4:574-85.
6. Available from: https://www.pharmatutor.org/articles/review-fast-dissolving-drug-delivery-system.
7. Mohamed HR, Jane B. Post-operative nausea and vomiting. Pharm J 2008;273:786.
8. Puja C, Rajesh K. A review on oral fast dissolving films a novel drug delivery system. Asian J Res Chem Pharm Sci 2016;4:165-75.
9. Shweta K, Mayank B. Recent trends in the development of oral dissolving film. Int J Pharm Tech Res 2012;4:725-33.
10. Yassin GE, Abass HA. Design and evaluation of fast dissolving Oro-dispersible films of metoclopramide hydrochloride using 32 multifactorial designs. Int J Pharm Pharm Sci 2016;8:218-22.
11. Rajni B, Shailesh S. Formulation and evaluation of fast dissolving film of aprepitant by using design of experiment. Bull Fac Pharm Cario Univ 2018;56:159-68.
12. Prabhakara P, Akhilesh D, Karthik K. Formulation and evaluation of fast-dissolving films of lisinopril. Egypt Pharm J 2015;14:56-64.
13. Dias RJ. Laboratory Manual of Biopharmaceutics and Pharmacokinetics. Satara: Trinity Publishing House; 2010. p. 22-4.
14. Viney C, Kamlesh U. Formulation and evaluation of mouth dissolving films of paracetamol. Int J Pharm Pharm Sci 2014;6:200-2.
Statistics
91 Views | 26 Downloads
How to Cite
ADITI D BAVISKAR, BARI MM, and BARHATE SD. “FORMULATION OPTIMIZATION AND EVALUATION OF MOUTH DISSOLVING FILM OF APREPITANT”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 12, no. 9, July 2019, pp. 154-63, https://innovareacademics.in/journals/index.php/ajpcr/article/view/34553.
Section
Original Article(s)