• Ashni Verma Chandigarh College of Pharmacy, Landran, Mohali, Punjab-140307


Objective: The aim of the study was to formulate Clobetasol propionate into a gel formulation using carbopol-934, Hydroxypropyl methylcellulose K4M, sodium alginate, Carboxymethylcellulose Sodium as gelling agents.

Method: In all the gels formulated, the concentration of propylene glycol and ethanol was kept constant at 15% and 40 % respectively. Clobetasol propionate was used in the concentration of 0.05% in all the gel formulations. Propylene glycol served as a co-solvent for drug. Triethanolamine was used to neutralize carbopol gel systems. Methyl paraben and propyl paraben were used as preservatives. A total of twenty two formulations were prepared with 6 formulation containing combination of various gelling agents. The total concentration of gelling agent in these six formulations was kept constant at 2%. The remaining sixteen formulations were prepared with the use of four different gelling agents viz., Carbopol-934, Hydroxypropyl methylcellulose K4m, Carboxymethylcellulose Sodium and Sodium Alginate.Formulations were evaluated for pH, homogeneity, grittiness, viscosity, spreadability, drug content and In-Vitro drug release studies.

Results: Drug content was high (>98 %) in gels. Carbopol-934 and Hydroxypropyl methylcellulose K4M gels showed higher release of .the drug compared to Carboxymethylcellulose Sodium and Sodium Alginate The viscosity of carbopol-934 gels was very high as compared to Hydroxypropyl methylcellulose K4M gels but both gels showed decrease in drug release with increase in polymer concentration. Similarly, gels prepared with combination of carbopol-934 and Hydroxypropyl methylcellulose K4M showed better drug release than gels prepared with Carboxymethylcellulose sodium and sodium alginate.

Conclusion: The study indicated that the polymer concentration significantly affects the drug release and rheological properties of the gel formulation. The study holds promise for further investigation in the development stable topical gels of clobetasol propionate.

Author Biography

Ashni Verma, Chandigarh College of Pharmacy, Landran, Mohali, Punjab-140307
Department of Pharmaceutics


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How to Cite
Verma, A. “FORMULATION AND EVALUATION OF CLOBETASOL PROPIONATE GEL”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 6, no. 9, Nov. 2013, pp. 15-18,