ACUTE TOXICITY STUDY OF (Z)-1-BENZHYDRYL-4- CINNAMYLPIPERAZINES IN SWISS ALBINO MICE


Chandrasekara G Reddy, Anaxee Barman, Shivaprakash S, Latha Diwakar

Abstract


 

Objective: The objective was to study the acute toxicity of (Z)-1-benzhydryl-4-cinnamylpiperazine derivatives (1a-c) using Swiss Albino mice.
Methods: The acute oral and dermal toxicity studies were carried out based on OECD guidelines by adopting fixed dosage method (the limit dose
is 2000 mg/kg body weight of test animal in case of dermal toxicity and 5000 mg/kg in oral toxicity). Toxicity and mortality rates were studied at
intervals of 6 hrs and 14 hrs after administration of test compounds for 14 days.
Results: (Z)-1-benzhydryl-4-cinnamyl piperazine derivatives (1a-c) at oral treatment of 5000 mg/kg BW and dermal toxicity study of 2000 mg/kg
BW did not show any pronounced toxicity indicating their potential use for therapeutic purposes.
Conclusion: All compounds 1a-c did not cause any mortality or changes in general behavior of the test animals at oral treatment of 5000 mg/kg BW
indicating no conspicuous toxicity at the highest dose administered.
Keywords: (Z)-1-benzhydryl-4-cinnamyl piperazine derivatives, Acute toxicity, Albino mice, Cinnarizine, Flunarizine.


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About this article

Title

ACUTE TOXICITY STUDY OF (Z)-1-BENZHYDRYL-4- CINNAMYLPIPERAZINES IN SWISS ALBINO MICE

Date

01-01-2015

Additional Links

Manuscript Submission

Journal

Asian Journal of Pharmaceutical and Clinical Research
Vol 8 Issue 1 (January-February) 2015 Page: 223-224

Print ISSN

0974-2441

Online ISSN

2455-3891

Authors & Affiliations

Chandrasekara G Reddy
Vittal Mallya Scientific Redearch Foundation
India

Anaxee Barman

Shivaprakash S

Latha Diwakar


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