PREDNISOLONE ENCAPSULATED SUPERPARAMAGNETIC IRON OXIDE NANOPARTICLES FOR TARGET DRUG DELIVERY – DESIGN AND QUANTIFICATION

  • SUBASHINI RAJARAM Department of Pharmaceutics and Research, Swamy Vivekanandha College of Pharmacy (Tamil Nadu DR. M.G.R. Medical University, Chennai),Namakkal, Tamil Nadu, India.
  • SENTHIL RAJAN DHARMALINGAM Department of Pharmaceutics and Research, Swamy Vivekanandha College of Pharmacy (Tamil Nadu DR. M.G.R. Medical University, Chennai),Namakkal, Tamil Nadu, India.
  • SANTHOSE RANI A Department of Pharmaceutics and Research, Swamy Vivekanandha College of Pharmacy (Tamil Nadu DR. M.G.R. Medical University, Chennai),Namakkal, Tamil Nadu, India.
  • SAPTHASRI R Department of Pharmaceutics and Research, Swamy Vivekanandha College of Pharmacy (Tamil Nadu DR. M.G.R. Medical University, Chennai),Namakkal, Tamil Nadu, India.
  • VARSHA D Department of Pharmaceutics and Research, Swamy Vivekanandha College of Pharmacy (Tamil Nadu DR. M.G.R. Medical University, Chennai),Namakkal, Tamil Nadu, India.
  • VINODHINI V Department of Pharmaceutics and Research, Swamy Vivekanandha College of Pharmacy (Tamil Nadu DR. M.G.R. Medical University, Chennai),Namakkal, Tamil Nadu, India.

Abstract

Objective: The present study aimed to develop a novel type of superparamagnetic iron oxide nanoparticles (SPIONs) to deliver prednisolone at colon as a target site for the treatment of inflammatory bowel disease (IBD) such as ulcerative colitis and Crohn’s disease which may further progress to cancer.


Methods: SPIONs were synthesized using a coprecipitation method. Further, it was encapsulated with prednisolone-polyethylene glycol by double emulsion method (W1/O/W2). The prepared formulations were characterized for its physicochemical characterization such as scanning electron microscopy, X-ray diffraction, particle size and zeta potential, encapsulation efficiency, and in vitro drug release.


Results: The results reveal that the physicochemical property of the formulations complies with the standard values and in vitro release of prednisolone in the first 18 h, attains 57 and 58% and it reaches 71 and 75% at 24 h, and this is statistically significant (p˂0.0177). This release result implies that the drug release from the formulations is controllable and sustains manner.


Conclusion: Our findings could be a promising approach for the delivery of prednisolone with enhanced half-life for the treatment of IBD through colon targeting.

Keywords: Superparamagnetic iron oxide nanoparticles, Prednisolone, Colon target drug delivery system, Polyethylene glycol, Coprecipitation method, Double emulsion method

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SUBASHINI RAJARAM, SENTHIL RAJAN DHARMALINGAM, SANTHOSE RANI A, SAPTHASRI R, VARSHA D, and VINODHINI V. “PREDNISOLONE ENCAPSULATED SUPERPARAMAGNETIC IRON OXIDE NANOPARTICLES FOR TARGET DRUG DELIVERY – DESIGN AND QUANTIFICATION”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 12, no. 11, Sept. 2019, pp. 126-31, doi:10.22159/ajpcr.2019.v12i11.35439.
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