• SWETHA PADIGELA Department of Pharmaceutical Chemistry, Vishnu Institute of Pharmaceutical Educational and Research, Narsapur, Telangana, India.
  • BHAGAVAN RAJU RM Department of Pharmaceutical Chemistry, Sri Venkateshwara College of Pharmacy, Hyderabad, Telangana, India.
  • RAJENDRA PRASAD VVS Center for Molecular Cancer Research, Vishnu Institute of Pharmaceutical Educational and Research, Narsapur, Telangana, India.


Objective: The objective of the study was to synthesize and evaluate the anticancer activity of some novel acridine derivatives.

Methods: The present works involve condensation of acridine and various 2, 4-Thiazolidine-2,4-dione derivatives (2a–2h) with chloroacetyl chloride to give a novel acridine derivatives (5a–5l), respectively.

Results: All the newly synthesized molecules (5a–5l) were characterized by FTIR, H1-NMR, and mass spectral analysis along with physical data. The biological potentials of the new synthesized compounds are evaluated for their in vitro anticancer activity by MTT assay.

Conclusion: The synthesized compounds 5a, 5f, and 5h exhibited good anticancer activity against MCF-7 and SKVO3 cancer cell lines at a concentration of 0.5 mg/mL-1.

Keywords: Acridine, 2, 4-Thiazolidinedione, Substituted aldehydes, Chloroacetyl chloride, Anticancer activity, MCF-7, SKVO3 cells


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How to Cite
PADIGELA, S., B. R. RM, and R. P. VVS. “SYNTHESIS, CHARACTERIZATION, AND ANTICANCER ACTIVITY OF SOME NOVEL ACRIDINE DERIVATIVES”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 13, no. 6, Apr. 2020, pp. 166-9, doi:10.22159/ajpcr.2020.v13i6.35794.
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