SYNTHESIS, CHARACTERIZATION, AND ANTICANCER ACTIVITY OF SOME NOVEL ACRIDINE DERIVATIVES

  • SWETHA PADIGELA Department of Pharmaceutical Chemistry, Vishnu Institute of Pharmaceutical Educational and Research, Narsapur, Telangana, India.
  • BHAGAVAN RAJU RM Department of Pharmaceutical Chemistry, Sri Venkateshwara College of Pharmacy, Hyderabad, Telangana, India.
  • RAJENDRA PRASAD VVS Center for Molecular Cancer Research, Vishnu Institute of Pharmaceutical Educational and Research, Narsapur, Telangana, India.

Abstract

Objective: The objective of the study was to synthesize and evaluate the anticancer activity of some novel acridine derivatives.


Methods: The present works involve condensation of acridine and various 2, 4-Thiazolidine-2,4-dione derivatives (2a–2h) with chloroacetyl chloride to give a novel acridine derivatives (5a–5l), respectively.


Results: All the newly synthesized molecules (5a–5l) were characterized by FTIR, H1-NMR, and mass spectral analysis along with physical data. The biological potentials of the new synthesized compounds are evaluated for their in vitro anticancer activity by MTT assay.


Conclusion: The synthesized compounds 5a, 5f, and 5h exhibited good anticancer activity against MCF-7 and SKVO3 cancer cell lines at a concentration of 0.5 mg/mL-1.

Keywords: Acridine, 2, 4-Thiazolidinedione, Substituted aldehydes, Chloroacetyl chloride, Anticancer activity, MCF-7, SKVO3 cells

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PADIGELA, S., B. R. RM, and R. P. VVS. “SYNTHESIS, CHARACTERIZATION, AND ANTICANCER ACTIVITY OF SOME NOVEL ACRIDINE DERIVATIVES”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 13, no. 6, Apr. 2020, pp. 166-9, doi:10.22159/ajpcr.2020.v13i6.35794.
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