ANTIHYPERLIPIDEMIC EFFECT OF ASPARAGUS GONOCLADOS BAKER AGAINST CHOLESTEROL DIET INDUCED HYPERLIPIDEMIA IN RATS.

  • NALLAM JAHNAVI Department of pharmacology, Krishna Teja College of Pharmacy, Tirupati-517501, Andhra Pradesh, India.
  • PRASAD. P. NAIDU Department of Biotechnology & Bioinformatics, Yogi Vemana University, Kadapa-516003 Andhra Pradesh, India.
  • KOTESWARA RAO. A Department of Biotechnology & Bioinformatics, Yogi Vemana University, Kadapa-516003 Andhra Pradesh, India.
  • KARUNASREE. C. P Department of pharmacology, Krishna Teja College of Pharmacy, Tirupati-517501, Andhra Pradesh, India.

Abstract

Objective: To evaluate the antihyperlipidemic potential of the Ethanolic Extract of Root tubers of Asparagus gonoclados (EERAG) in cholesterol diet induced hyperlipidemic rats.


Methods: Wistar albino rats were randomly divided into five groups of six each. Group-I served as normal control. Groups II to V were given 5% cholesterol diet for 3 months to induce hyperlipidemia, and for last 28 days were administered either: 0.5ml water/saline for Group- I; cholesterol diet (5%) for Group-II; Standard drug Rosuvastatin (20mg/kg body weight) for Group-III; A.gonoclados extract at 250 mg/kg bodyweight for Group-IV and 500mg/kg body weight for Group-V. The effects of EERAG on serum lipid profile, Body Weight and antioxidant enzymes (Superoxide Dismutase and Catalase) were assessed and compared.


Results: Cholesterol diet induced hyperlipidemic rats showed an significant (P<0.001) increase in the plasma concentration of Total Cholesterol (TC), Triglycerides (TG), Low-Density Lipoprotein cholesterol (LDL-c), Very Low-Density Lipoprotein cholesterol (VLDL-c) and body weight. Decrease in High Density Lipoproteins Cholesterol (HDL-c) and antioxidant enzymes were observed when compared to normal control rats. Co-administration of EERAG and standard drug Rosuvastatin with high cholesterol diet caused a significant decrease (p<0.001) in the concentration of serum TC, VLDL, TG, body weight and increase in the HDL-c and antioxidant enzymes when compared with cholesterol fed control rats.


Conclusion: The result suggests lipid lowering and antioxidant potential of effect of A. gonoclados, which serves as a new potential herbal product for preventing hyperlipidemia.

Keywords: Asparagus gonoclados, Cholesterol, Hyperlipidaemia, Lipid profile, Antioxidant enzymes
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How to Cite
NALLAM JAHNAVI, PRASAD. P. NAIDU, KOTESWARA RAO. A, and KARUNASREE. C. P. “ANTIHYPERLIPIDEMIC EFFECT OF ASPARAGUS GONOCLADOS BAKER AGAINST CHOLESTEROL DIET INDUCED HYPERLIPIDEMIA IN RATS.”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 12, no. 12, Dec. 2019, p. 262, https://innovareacademics.in/journals/index.php/ajpcr/article/view/36564.
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Erratum