ADVANCED MOLECULAR AND CELL BASED THERAPIES FOR ATHEROSCLEROSIS


Md Rahmathulla S. B, K. Lakshmi Devi

Abstract


Cardiovascular disease (CVD) is the most frequent cause of premature death in modern industrialized countries, accounting for 4.35 million deaths each year in Europe, and 35% of deaths in the United Kingdom. Atherosclerosis is pathological process characterized by formation of subintimal plaques that can reduce or obstruct blood flow through the vessel. It is a result of normal blood vessels ageing, with initial lesion developing before age 30 (so-called fatty streaks). Risk factors that significantly accelerate this process are serum lipid impairment, hypertension, cigarette smoking, diabetes mellitus, obesity, physical inactivity and hereditary factors i.e. positive family history of cardiovascular disorders. . Compelling experimental and clinical evidence has demonstrated that both systemic and local inflammation might play a prominent role in the pathogenesis of atherosclerosis and its clinical complications. Since inflammatory processes accompany all stages of atherosclerosis, measurement of plasma/serum concentrations of circulating inflammatory biomarkers might aid in identifying individuals at high risk for cardiovascular disease (CVD). Currently employed treatment strategies include risk factor modification, conventional pharmacotherapy, and percutaneous or surgical revascularization. Yet despite these interventions disease progression often results in recurrent symptoms, with many patients exhausting all therapeutic options.

KEY WORDS: Atherosclerosis, Risk Factors, Pathophysiology, Inflammation. Biomarkers for Atherosclerosis, Polyphenols, Molecular and Cell Based Therapies

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References


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About this article

Title

ADVANCED MOLECULAR AND CELL BASED THERAPIES FOR ATHEROSCLEROSIS

Date

01-01-2015

Additional Links

Manuscript Submission

Journal

Asian Journal of Pharmaceutical and Clinical Research
Vol 8 Issue 1 (January-February) 2015 Page: 54-59

Print ISSN

0974-2441

Online ISSN

2455-3891

Authors & Affiliations

Md Rahmathulla S. B
1Department of Biochemistry, Sri Krishnadevaraya University, Anantapuramu, India 2Department of Biochemistry, College of Medicine and Health Sciences, Gondar (Ethiopia).
India

K. Lakshmi Devi


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