NEUROPROTECTIVE EFFECT OF HYDROALCOHOLIC EXTRACT OF AMARANTHUS TRICOLOR LEAVES ON EXPERIMENTAL ANIMALS

VIDHAN CHAND BALA; MOHD ABID

doi:10.22159/ajpcr.2020.v13i6.37181

Authors

VIDHAN CHAND BALA Department of Pharmacology, School of Pharmacy, IFTM University, Moradabad, Uttar Pradesh, India.
MOHD ABID Department of Pharmacology, School of Pharmacy, IFTM University, Moradabad, Uttar Pradesh, India.

DOI:

https://doi.org/10.22159/ajpcr.2020.v13i6.37181

Keywords:

Amaranthus tricolor, Neuroprotective effect, Scopolamine, Anti-stress activity, Nootropic activity, Anti-cataleptic activity

Abstract

Objective: The research work deals with the screening of hydroalcoholic extract of Amaranthus tricolor (HAEATL) leaves for central nervous system activity (anti-stress, nootropic, and anti-cataleptic activity).

Methods: The screening of scopolamine and different model-induced neurodisorder rats were treated with 200 and 400 mg/kg body weight dose of hydroalcoholic extract of A. tricolor lives in 7 days’ experimental schedule. It has been reported that the antioxidant, hepatoprotective, hematological, and antimicrobial activities.

Results: The result of the study reflected that HAEATL (200 and 400 mg/kg) was effective in all methods and showed anti-stress, nootropic, and anti-cataleptic activity in a dose-dependent manner. The results are represented that the HAEATL produce the significant decreased the swimming time, increased the anoxia time, decreased level of biochemical parameters such as glucose and cholesterol except blood urea nitrogen, decreased level of white blood cell and red blood cell, and more significantly decreased the catalepsies score on 7th day compared to the control group.

Conclusion: The above valuable animal study, we concluded that the HAEATL showing significantly affect compeer to the disease control group on neuroprotective activity.

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