A COMPARATIVE STUDY OF ANTI-NOCICEPTIVE ACTIVITY OF CURCUMA LONGA LINN. WITH THAT OF IBUPROFEN IN EXPERIMENTAL ANIMALS

  • SWOPNA PHUKAN Department of Pharmacology, Gauhati Medical College, Guwahati, Assam.
  • SAHELI DAS Department of Pharmacology, Gauhati Medical College, Guwahati, Assam.

Abstract

Objective: The aim of the study is to evaluate and compare the analgesic activities of Curcuma longa Linn. in the experimental animals.


Methods: The present study was conducted in the Department of Pharmacology, Gauhati Medical College and Hospital, after getting approval from the Institutional Animal Ethics Committee (No MC/68F/2009/MAR-19/02). Healthy rodents weighing between 150 and 200 g were selected and randomly divided into five groups, each group consisting of six animals. Tail-flick analgesiometer was used to assess the analgesic activity of C. longa Linn. and ibuprofen in the experimental animals. Appropriate statistical analyses like Student’s t-test were used to analyze the data.


Results: The mean reaction time (s) was prolonged on gradually increasing the dose of C. longa Linn. from 200 to 400 mg/kg. At 400 mg/kg dose C. longa Linn. produced similar analgesic activity as compared to ibuprofen (30 mg/kg).


Conclusion: From the study, it can be concluded that curcumin has the capacity to attenuate pain, and when administered in high doses, may produce similar activity as other conventional NSAID’s.

Keywords: Curcuma longa, Ibuprofen, Anti-nociceptive activity

References

1. Sodhi V. Ayurvedic Science Update: Turmeric for Cancer; 2006. Available from: http://www.ayurvedicscience.com. [Last accessed on 2019 Dec 10].
2. Arora RB, Kapoor V, Basu N, Jain AP. Anti-inflammatory studies on Curcuma longa (Turmeric). Indian J Med Res 1971;59:1289-95.
3. Chandra D, Gupta S. Anti-inflammatory and anti-arthritic activity of volatile oil of Curcuma longa (Haldi). Indian J Med Res 1972;60:138-42.
4. Deodhar SD, Senthi R, Srimal RC. Preliminary study on antirheumatic activity of curcumin (diferuloyl methane). Indian J Med Res 1980;71:632-4
5. Bose S, Panda AK, Mukherjee S. Curcumin and tumor immune-editing: Resurrecting the immune system. Cell Div 2015;10:6.
6. Mehta K, Pantazis P, Mc Queen T, Aggarwall BB. Antiproliferative effect of curcumin (diferuloylmethane) against human breast tumor cell lines. Anticancer Drugs 1997;8:470-81.
7. Jagetia GC, Aggarwal BB. Spicing up of the immune system by curcumin. J Clin Immunol 2007;27:19-35.
8. Cooper SA. The relative efficacy of ibuprofen in dental pain. Compend Contin Educ Dent 1986;7:578, 580-1, 584-8.
9. Neha S, Ravir GD, Jangade CR. Analgesic and antipyretic activities of Curcuma longa rhizome extracts in Wister rats. Vet World 2009;2:304-6.
10. Sharma A, Rauniar GP. Antinociceptive effects of purified Curcuma longa in mice. Int J Basic Clin Pharmacol 2016;5:484-90.
11. Ojewole JA. Analgesic, antiinflammatory and hypoglycaemic effects of ethanol extract of Zingiber officinale (Roscoe) rhizomes (Zingiberaceae) in mice and rats. Phytother Res 2006;20:764-72.
12. Hajare SW, Chandrika S, Tandan SK, Sarma J, Lal J, Telang AG. Analgesic and antipyretic activities of Dalbergia sissoo leaves. Indian J Pharmacol 2000;32:357-60.
13. Sulthana N, Vijaya K, Madhavi BB. Effect of curcumin on chemically induced osteoarthritis. Int J Pharm Pharm Sci 2017;9:182-7.
14. Saini A, Saini G, Singh B, Vyas M, Verma S, Prakash O. Synergistic effect of Azadirachta indica and Curcuma longa with fluconazole gel against Candida albicans. Int J Pharm Pharm Sci 2018;10:692-700.
Statistics
30 Views | 48 Downloads
Citatons
How to Cite
PHUKAN, S., and S. DAS. “A COMPARATIVE STUDY OF ANTI-NOCICEPTIVE ACTIVITY OF CURCUMA LONGA LINN. WITH THAT OF IBUPROFEN IN EXPERIMENTAL ANIMALS”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 13, no. 6, Mar. 2020, pp. 51-53, doi:10.22159/ajpcr.2020.v13i6.37224.
Section
Original Article(s)