FORMULATION AND EVALUATION OF CREAMS CONTAINING CELECOXIB INCLUSIONS FOR TREATING PSORIATIC ARTHRITIS

  • ROOPA RANI N Department of Pharmaceutics, Dr. K.V. Subba Reddy Institute of Pharmacy, Kurnool, Andhra Pradesh, India.
  • SUDHARSHAN B Department of Pharmaceutics, Dr. K.V. Subba Reddy Institute of Pharmacy, Kurnool, Andhra Pradesh, India.
  • SHIVA PULLA REDDY G Department of Pharmaceutics, Dr. K.V. Subba Reddy Institute of Pharmacy, Kurnool, Andhra Pradesh, India.
  • PADMINI IRIVENTI Department of Pharmaceutics, Dr. K.V. Subba Reddy Institute of Pharmacy, Kurnool, Andhra Pradesh, India.

Abstract

Objective: The main objective of the present work was to prepare and evaluate creams of celecoxib inclusions which are nonsteroidal anti-inflammatory drug to treat psoriatic arthritis.


Methods: Celecoxib inclusions were prepared using β-cyclodextrin to increase the solubility. These inclusions were incorporated in creams. Cocoa butter, triethanolamine, stearic acid, methylparaben, gum acacia, and coconut oil were used in cream preparation. Fourier transform infrared and differential scanning calorimetry studies were carried out for pure celecoxib and inclusions. Viscosity, pH, homogeneity, and type of emulsion under dye test were evaluation parameters done for creams.


Results: All the results obtained were within the limits and confirmed increased solubility of celecoxib inclusions.


Conclusion: From the results obtained, increase in solubility of celecoxib drug was confirmed by forming inclusions using β-CD as polymer.

Keywords: β-cyclodextrin, Psoriatic Arthritis, Creams, Celecoxib, Inclusions

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RANI N, R., S. B, S. P. REDDY G, and P. IRIVENTI. “FORMULATION AND EVALUATION OF CREAMS CONTAINING CELECOXIB INCLUSIONS FOR TREATING PSORIATIC ARTHRITIS”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 13, no. 6, Apr. 2020, pp. 41-45, doi:10.22159/ajpcr.2020.v13i6.37469.
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