ROLE OF ANTIDEPRESSANT ON THE GLYCAEMIC CONTROL OF UNCONTROLLED TYPE 2 DIABETES MELLITUS PATIENTS

  • ALLU HARSHAVARDHINI Department of General Medicine, JSS Medical College and Hospital, JSS Academy of Higher Education and Research, Mysuru, Karnataka, India.
  • BHANUKUMAR MUTHAIAH Department of General Medicine, JSS Medical College and Hospital, JSS Academy of Higher Education and Research, Mysuru, Karnataka, India.
  • TIRIN BABU Department of Pharmacy Practice, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Mysuru, Karnataka, India.
  • GEORGE MATHEW PANACHIYIL Department of Pharmacy Practice, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Mysuru, Karnataka, India.
  • SISIRA SANTHOSH Department of Anaesthesiology, IMS and SUM Hospital, Bhubaneswar, Odisha, India.
  • SARAYU SANTHOSH Department of General Medicine, Adichunchanagiri Institute of Medical Sciences, Mandya, B.G Nagara, Karnataka, India.

Abstract

Background: Depression incidence is higher in diabetic patients when compared to the non-diabetic individuals and there exist a two-directional relationship between depression and the development of type 2 diabetes mellitus.


Objectives: This study aimed to estimate the frequency of depression and the effect of antidepressant on glycemic control in type 2 diabetes mellitus patients.


Methods: This prospective interventional study was conducted in type 2 diabetes mellitus patients with a sample size of 100. These patients were diagnosed with depression using WHO-ICD10 criteria. All study patients had uncontrolled blood glucose levels and were on an optimized maximal dose of combination oral hypoglycemic agents with stable glycoregulation (HbA1c 8.4 ±0.5) were taken up for the intervention with antidepressant. These patients were started on with antidepressant after enrollment and followed up for fasting blood sugar (FBS), post-prandial blood sugar (PPBS), and HbA1c at the end of 3 months and 6 months. And also Hamilton depression rating scale scores were estimated at the beginning of the study and at the end of 6 months.


Results: The frequency of depression among the type 2 diabetes mellitus patients was found to be 42%. There were reduction of mean FBS levels from baseline value of 177 mg/dl to follow-up value of 160 mg/dl (p<0.001), mean PPBS levels from 251.16 mg/dl to 217.84 mg/dl (p<0.001), and mean HbA1c dropped from 8.41 to 7.57 (p<0.001) after the treatment with antidepressant.


Conclusion: Our study concluded that patient started on antidepressant showed a reduction in the blood sugar levels and HbA1c levels from their baseline values, which was clinically and statistically significant.

Keywords: Type 2 diabetes mellitus, Depression, Antidepressant, Glycemic control

Author Biographies

ALLU HARSHAVARDHINI, Department of General Medicine, JSS Medical College and Hospital, JSS Academy of Higher Education and Research, Mysuru, Karnataka, India.

M.D. General Medicine, Department of General Medicine, JSS Medical College and Hospital, JSS Academy of Higher Education & Research, Mysuru, Karnataka – 570015, India.

BHANUKUMAR MUTHAIAH, Department of General Medicine, JSS Medical College and Hospital, JSS Academy of Higher Education and Research, Mysuru, Karnataka, India.

Professor, Department of General Medicine, JSS Medical College and Hospital, JSS Academy of Higher Education & Research, Mysuru, Karnataka – 570015, India.

TIRIN BABU, Department of Pharmacy Practice, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Mysuru, Karnataka, India.

Department of Pharmacy Practice, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Mysuru, Karnataka – 570015, India

GEORGE MATHEW PANACHIYIL, Department of Pharmacy Practice, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Mysuru, Karnataka, India.

Department of Pharmacy Practice, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Mysuru, Karnataka – 570015, India

SISIRA SANTHOSH, Department of Anaesthesiology, IMS and SUM Hospital, Bhubaneswar, Odisha, India.

MBBS, Adichunchanagiri Institute of Medical Sciences, Mandya Dist, B.G Nagara, Karnataka 571448.

SARAYU SANTHOSH, Department of General Medicine, Adichunchanagiri Institute of Medical Sciences, Mandya, B.G Nagara, Karnataka, India.

MBBS, Adichunchanagiri Institute of Medical Sciences, Mandya Dist, B.G Nagara, Karnataka 571448.

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HARSHAVARDHINI, A., B. MUTHAIAH, T. BABU, G. M. PANACHIYIL, S. SANTHOSH, and S. SANTHOSH. “ROLE OF ANTIDEPRESSANT ON THE GLYCAEMIC CONTROL OF UNCONTROLLED TYPE 2 DIABETES MELLITUS PATIENTS”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 13, no. 7, May 2020, pp. 111-4, doi:10.22159/ajpcr.2020.v13i7.37809.
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