HEPATOPROTECTIVE ACTIVITY OF METHANOLIC EXTRACT OF LEAVES OF ROSTELLULARIA PROCUMBENS BY USING ETHANOL INDUCED MODEL IN RATS
The present study was carried out to evaluate the hepatoprotective activity of leaves of Rostellularia procumbens (Acanthaceae) .The plant extract was prepared and examined against ethanol induced liver damage in wistar rats using silymarin as standard. The extract was screened for alkaloids, steroids, proteins, flavanoides, saponins, carbohydrates, tannins and glycosides. Enzyme activities of Serum glutamate oxaloacetate (SGOT), Serum glutamate pyruvate transaminase (SGPT), Alkaline phosphatase, Total bilirubin and Total protein levels are analysed. Results indicate that the methanolic leaf extract had protective activity over ethanol induced hepatotoxicity when compared with toxic control and silymarin groups. Results of present investigation confirm the hepatoprotective activity of MERP at 250mg/kg and 500mg/kg doses. The statistical analysis was carried out using one way analysis of varience (ANOVA) followed by Dunnet's t-test. P â€“values <0.05 were considered as significant.Key words: Rostellularia procumbens , SGOT, SGPT, TB, TP,ALP, ethanol
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