COMPARATIVE STUDY TO ASSESS THE EFFECTIVENESS OF NEBULIZED 3% HYPERTONIC SALINE AND NEBULIZED LEVOSALBUTAMOL IN THE MANAGEMENT OF BRONCHIOLITIS

  • SARA SHIREEN Department of Pharmacy Practice, Deccan School of Pharmacy, Hyderabad, Telangana, India.
  • SAFURA SULTANA Department of Pharmacy Practice, Deccan School of Pharmacy, Hyderabad, Telangana, India.
  • KHADIJA AKHTAR OMER Department of Pharmacy Practice, Deccan School of Pharmacy, Hyderabad, Telangana, India.
  • ATIKA BEGUM QUTUB Department of Pharmacy Practice, Deccan School of Pharmacy, Hyderabad, Telangana, India.
  • NARAYAN REDDY U Department of Paediatrics, Princess Esra Hospital, Deccan College of Medical Sciences, Hyderabad, Telangana, India.

Abstract

Objective: The objective of the study was to compare the effects of nebulized 3% hypertonic saline and nebulized levosalbutamol in the management of bronchiolitis.


Methods: Seventy children of age 1–24 months admitted into the hospital with the diagnosis of bronchiolitis. Participants were divided into two groups of 35 each. Group A was given nebulized 3% hypertonic saline and Group B was given nebulized levosalbutamol. Modified respiratory distress assessment instrument (RDAI) is used at admission, at 48 h after admission, and at the time of discharge to identify the reduction in scores between two groups.


Results: The mean age of patients in the study population was 10.1±6.4 months. The mean birth weight of patients in Group A and Group B was 3.00±0.61 and 3.12±0.75. The percentage of male patients was 57.1% and the percentage of female patients was 42.8%. The modified RDAI score in Group A and Group B at admission, 48 h of admission, and at the time of discharge was 4.34±0.87, 2.4±1.03, and 0.67±0.05 (p=0.04) and 4.11±0.58, 3.60±1.00, and 2.51±0.96 (p=0.12). The hospital stay was observed to be lowered in Group A (3.77±0.88) compared to Group B (5.43±0.92; p=0.04).


Conclusion: From the findings of our study, we conclude that nebulized 3% hypertonic saline, as it acts by hindering the pathophysiologic mechanism of bronchiolitis, is more effective in reducing the clinical severity score and length of hospital stay. Further 3% hypertonic saline also have the additional benefit of decreasing the economic burden of disease as it is safe, inexpensive, reduces the inpatient hospital charges by reducing the length of stay.

Keywords: Bronchiolitis, 3% hypertonic saline, Levosalbutamol, Modified respiratory distress assessment instrument, Nebulization

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SHIREEN, S., S. SULTANA, K. A. OMER, A. B. QUTUB, and N. REDDY U. “COMPARATIVE STUDY TO ASSESS THE EFFECTIVENESS OF NEBULIZED 3% HYPERTONIC SALINE AND NEBULIZED LEVOSALBUTAMOL IN THE MANAGEMENT OF BRONCHIOLITIS”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 13, no. 10, Aug. 2020, pp. 93-95, doi:10.22159/ajpcr.2020.v13i10.38103.
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