SYNTHESIS OF NOVEL CHALCONES OF SCHIFF'S BASES AND TO STUDY THEIR EFFECT ON BOVINE SERUM ALBUMIN

Authors

  • Shweta Garg
  • Neera Raghav

Abstract

Objective: Some novel chalcones consisting –unsaturated carbonyl group and C=N bond were synthesized i.e. 1-(4-(benzylideneamino)phenyl)-3-phenylprop-2-en-1-ones and studied the influence of their  presence on bovine serum albumin.

Methods: 1-(4-(benzylideneamino)phenyl)-3-phenylprop-2-en-1-ones were synthesized by the reaction of substituted benzaldehydes with 1-((4-benzylideneamino)phenyl)ethanone and in the presence of a base. The structures were confirmed by their IR and 1HNMR spectra. After establishing the structures of 1-(4-(benzylideneamino)phenyl)-3-phenylprop-2-en-1-ones, their effect were observed on BSA in solution.

Results: Out of synthesized chalcones, 1-(4-(4-(3-phenylallylideneamino)phenyl)-3-p-tolylprop-2-en-1-one is most reactive chalcone as it decreased the availability of BSA in solution to maximum extent.

Conclusion: 1-(4-(benzylideneamino)phenyl)-3-phenylprop-2-en-1-ones interact with the bovine serum albumin which is responsible for the transportation of a number of compounds.

Keywords: Bovine serum albumin, interaction studies, chalcones.

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Published

2013-09-01

How to Cite

Garg , S., and N. Raghav. “SYNTHESIS OF NOVEL CHALCONES OF SCHIFF’S BASES AND TO STUDY THEIR EFFECT ON BOVINE SERUM ALBUMIN”. Asian Journal of Pharmaceutical and Clinical Research, vol. 6, no. 8, Sept. 2013, pp. 181-4, https://innovareacademics.in/journals/index.php/ajpcr/article/view/382.

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