• DYAH UTAMI CAHYANING RAHAYU Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Indonesia, Depok 16424, Indonesia.
  • DWI AYU SETYANI Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Indonesia, Depok 16424, Indonesia.
  • HANHAN DIANHAR Chemistry Study Program, Faculty of Mathematics and Natural Sciences, Universitas Negeri Jakarta, Jakarta 13220, Indonesia.
  • PURWANTININGSIH SUGITA Department of Chemistry, Faculty of Mathematics and Natural Sciences, Institut Pertanian Bogor, Dramaga Bogor 16680, Indonesia.


Objective: The aim of the present study is to isolate phenolic compounds from Curcuma zedoaria rhizomes grown in Bogor, West Java, Indonesia, which will enrich phytochemical information from this plant.

Methods: C. zedoaria rhizomes were macerated in methanol then followed by increasing polarity partitions with n-hexane, ethyl acetate (EtOAc), and methanol, respectively. EtOAc fraction was further fractionated using various chromatography techniques to yield two isolated fractions, Z1 and Z2. These two isolated fractions were then characterized to determine their compound structures.

Results: According to Fourier transform-infrared, ultraviolet-vis, and liquid chromatography–mass spectrometry (MS)/MS data, Z1 fraction was elucidated as curcuminoid derivative, that is, dimethoxycurcumin (DiMC, 1), while Z2 fraction was yielded as a mixture consisted of flavonoid and coumarin derivatives, that is, 3,5,7-trihydroxy-4’-methoxyflavon (kaempferide, 2) and 7-methoxy coumarin (herniarin, 3).

Conclusion: This study reveals useful information regarding phenolic constituents of Indonesian C. zedoaria rhizomes. Further research needs to be carried out to purify other compounds contained and to conduct bioactivity assays.

Keywords: Curcuma zedoaria, Dimethoxycurcumin (DiMC, 1), Phenolic, 7-methoxy coumarin (herniarin, 3), 3,5,7-trihydroxy-4’-methoxyflavon (kaempferide, 2), White turmeric


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How to Cite
DYAH UTAMI CAHYANING RAHAYU, DWI AYU SETYANI, HANHAN DIANHAR, and PURWANTININGSIH SUGITA. “PHENOLIC COMPOUNDS FROM INDONESIAN WHITE TURMERIC (CURCUMA ZEDOARIA) RHIZOMES”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 13, no. 7, June 2020, pp. 194-8, doi:10.22159/ajpcr.2020.v13i7.38249.
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