PREVALENCE OF EXTENDED SPECTRUM BETA LACTAMASE PRODUCING UROPATHOGENS IN PREGNANT WOMEN


Pramila Lamichhane, Rekha Thapa, Megha Raj Banjara, Ganesh Prasad Acharya

Abstract


 

Objective: This study aims to determine the prevalence of urinary tract infection (UTI) among pregnant women and multidrug-resistant (MDR)
uropathogens with reference to extended spectrum beta-lactamase (ESBL) producers.
Methods: Three hundred urine specimens collected from pregnant women were studied. A semi-quantitative method was used for diagnosis of UTI.
Isolation, identification, and antimicrobial susceptibility of an organism was done by standard microbiological procedure. ESBLs production was
detected by double-disc synergy test method.
Results: UTI was found among 30.5% of pregnant women. Among 137 Gram-negative bacterial isolates, 72.0% were found to be MDR while only
7.30% were ESBL producers. Among total of Escherichia coli and Klebsiella pneumoniae isolates, 7.69% and 15.38%, respectively, were found
to be ESBL producers. Parity (odds ratio [OR]: 1.58, p<0.05), education status (OR: 4.07, p<0.01), occupation of pregnant women (OR: 1.86,
p<0.05), times of bathing (OR: 3.45, p<0.01), history of UTI (OR: 20.79, p<0.01) were found to be significantly associated with UTI from both
univariate and multivariate analysis. Gentamicin, nitrofurantoin, ceftazidime, and amikacin were found to be the most effective antibiotic against
uropathogens.
Conclusion: Frequent and consistent evaluation of the prevalence, etiologic agents, and predisposing factors of UTI during pregnancy is necessary in
developing countries like Nepal in order to reduce its devastation effects during pregnancy on both maternal and fetal health. It is essential to have a
regular and routine monitoring of ESBL producing clinical isolates in laboratory practice.
Keywords: Pregnant women, Urinary tract infection, Multidrug resistance, Extended spectrum beta-lactamase.


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About this article

Title

PREVALENCE OF EXTENDED SPECTRUM BETA LACTAMASE PRODUCING UROPATHOGENS IN PREGNANT WOMEN

Date

01-01-2015

Additional Links

Manuscript Submission

Journal

Asian Journal of Pharmaceutical and Clinical Research
Vol 8 Issue 1 (January-February) 2015 Page: 207-210

Print ISSN

0974-2441

Online ISSN

2455-3891

Authors & Affiliations

Pramila Lamichhane
Tribhuvan University Universal College of Medical Sciences
Nepal

Rekha Thapa
Tribhuvan University
Nepal

Megha Raj Banjara
Tribhuvan University
Nepal

Ganesh Prasad Acharya
Paropakar Maternity and Women's Hospital
Nepal


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