• RUPALI CHANDA Department of Pharmaceutics, The Oxford College of Pharmacy, Hongasandra, Bengaluru, Karnataka, India.
  • LAVANYA NALLAGUNTLA Department of Pharmaceutics, The Oxford College of Pharmacy, Hongasandra, Bengaluru, Karnataka, India.


Objective: The objective of the present work was to formulate and evaluate lozenges for a sore throat using Loratadine. Loratadine is a long-acting peripheral H1-receptor antagonist which is mainly used as an antihistamine. Loratadine lozenges were prepared to prevent the itching and inflammation in sore throat.

Methods: Solid dispersion of Loratadine was prepared using β-cyclodextrin in the ratios of 1:1, 1:2, and 1:3 to enhance the solubility of Loratadine. The prepared solid dispersion of Loratadine was analyzed for solubility enhancement. Loratadine lozenges were then formulated with mannitol, sucrose, acacia, xanthan gum, liquid glucose by heat, and congealing technique. The prepared lozenges were evaluated for drug-excipient incompatibility study, diameter, thickness, weight variation, hardness, friability, in vitro release study, and drug content.

Results: The results of the Fourier transform infrared study showed that there was no interaction between the selected drug and excipients. In vitro drug release study of Loratadine lozenges were performed in pH 6.8 phosphate buffer, wherein >90% of the drug was released within 30 min for all the formulations. The lozenges were optimized based on in vitro release data. Formulation F7 of Loratadine lozenges exhibited 99.1% release in 30 min. Stability studies revealed that the formulation was stable.

Conclusion: From the present work, it was concluded that the Loratadine lozenges can be considered as a suitable delivery system for the treatment of sore throat.

Keywords: Lozenge, Loratadine, Heat and congealing method, Sore throat

Author Biography

RUPALI CHANDA, Department of Pharmaceutics, The Oxford College of Pharmacy, Hongasandra, Bengaluru, Karnataka, India.



1. Gupta H, Bhandari D, Sharma A. Recent trends in oral drug delivery: A review. Recent Pat Drug Deliv Formul 2009;3:162-73.
2. Purushotham RK, Venkateshwarlu P, Shashikala P, Saran SV, Ravindranath A, Ashok KC. Medicated lollipops for the treatment of oral thrush in children. Int J Life Sci Biotechnol Pharm Res 2012;1:95-102.
3. Pundir S, Varma AM. Formulation development and evaluation of antiemetic lozenges of ondansetron hydrochloride. Int J Pharm Biol Sci 2014;1:365-72.
4. Phaechamud T, Tuntarawongsa S. Clotrimazole soft lozenges fabricated with melting and mold technique. Res J Pharm Bio Chem Sci 2010;1:579-86.
5. Dahiya J, Jalwal P, Arora S, Singh B. Formulation and evaluation of chewable tablets of loratadine by direct compression method. Pharma Innov 2015;4:97.
6. Sastry SV, Nyshadham JR, Fix JA. Recent technological advances in oral drug delivery-a review. Pharm Sci Tech Today 2000;3:138-45.
7. McElhiney LF. Education, training, and evaluation of hospital compounding personnel. Int J Pharm Compd 2006;10:361.
8. Jagadeesh P, Ahammad DA, Devi GG, Mohiddin YK, Naveen R, Lakshmi BP, et al. Review on medicated lozenges. Int J Innov Pharm Sci Res 2019;7:11-25.
9. Controller of Publication. Pharmacopoeia. Vol. 1. New Delhi, Indian: Controller of Publication; 2007. p. 1576.
10. Ghosh PK, Sharma HK, Boruah N. Different methods used in solid dispersion. J Pharm 2018;8:28-38.
11. Chaudhari PD, Chaudhari SP, Lanke SD, Nakul P. Formulation and in vitro evaluation of taste masked orodispersible dosage form of levocetirizine dihydrochloride. Indian J Pharm Educ 2007;41:319-28.
12. Rao KP, Kumar CA, Afshanlaheji AK, Manjunath P, Baburao NC. Formulation and evaluation of anti-asthmatic theophylline tablet lozenges. Int J Pharm Sci 2011;3:125-8.
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How to Cite
CHANDA, R., and L. NALLAGUNTLA. “FORMULATION AND EVALUATION OF MEDICATED LOZENGES FOR SORE THROAT”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 13, no. 10, Oct. 2020, pp. 62-67, doi:10.22159/ajpcr.2020.v13i10.38660.
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