PREPARATION AND INVITRO EVALUATION OF METOPROLOL LOADED BOVINE SERUM ALBUMIN NANOPARTICLES
The aim of present research was to prepare metoprolol loaded nanospheres.Metoprolol loaded bovine albumin nanospheres were prepared by nanoprecipitation method.metoprolol is beta-1-adrenergic receptor inhibitor specific to cardiac cells thus producing negative chronotropic and ionotropic effect.
Methods:Metoptolol Nanospheres were prepared by Nanoprecipitation method,using bovine serum albumin as polymer.The prepared nanospheres are evaluated for particle size evaluation , drug entrapment efficiency, Zeta potential.Drug excipient compatibility was determined using fourier transform infrared spectroscopy. Invitro release and solubility of the drug from nanoparticles were determined.
Results:The particle size of prepared metoprolol nano spheres was found to be always less than 200nm.maximum particle size was found to be 196±2.03nm of batch 4 nanoparticles .Entrapment efficiency of prepared nanospheres was above 80% and maximum percentage entrapment efficiency was found to be 80.4±0.51%.It was found that the percentage entrapment efficiency and drug release was extended with increase in polymer concentration.Zeta potential of the optimized formulation was found to be -20.4mV.Invitro drug release studies has shown the prolonged release of 94.5±0.54 upto 10 hrs. Drug release rate is extended with an increase in polymer concentration.
Conclusion:Results has concluded that the albumin nanospheres loaded with metoprolol has reduced the blood pressure within 24hrs and the prepared nanospheres are effective compared to other formulations and drug delivery.
This work is licensed under a Creative Commons Attribution 4.0 International License.
The publication is licensed under CC By and is open access. Copyright is with author and allowed to retain publishing rights without restrictions.