SMOKING CARCINOGENS AND LUNG CANCER – A REVIEW

  • VINAY S Department of Biotechnology and Bioinformatics, School of Life Sciences, JSS Academy of Higher Education and Research, Mysuru, Karnataka, India.
  • CHANDAN DHARMASHEKARA Department of Biotechnology and Bioinformatics, School of Life Sciences, JSS Academy of Higher Education and Research, Mysuru, Karnataka, India.
  • ASHWINI PRASAD Department of Microbiology, School of Life Sciences, JSS Academy of Higher Education and Research, Mysuru, Karnataka, India.
  • KOLLUR SHIVA PRASAD Department of Sciences, Amrita School of Arts and Sciences, Amrita Vishwa Vidyapeetham, Mysuru Campus, Mysuru, Karnataka, India.
  • CHANDRASHEKAR SRINIVASA Department of Biotechnology, Davangere University, Shivagangotri, Davangere, Karnataka, India
  • KAVITHA GC Department of Biotechnology, Davangere University, Shivagangotri, Davangere, Karnataka, India
  • POOJITHA B. SRIDHARA SETTY Department of Biotechnology, Davangere University, Shivagangotri, Davangere, Karnataka, India
  • CHANDAN SHIVAMALLU Department of Biotechnology and Bioinformatics, School of Life Sciences, JSS Academy of Higher Education and Research, Mysuru, Karnataka, India.

Abstract

Smoking ambiguity contributes to a certain revelation regarding the process by which cancer is induced. In the laboratory, carcinogens induce clear lung tumor to lung cancer induction. For instance, carcinogenic chemicals, namely, 4(methyl nitrosomine)-1-(3-pyridyl)-1-butanol, and nitrosonornicotine (NNN) cause tumor malignancy. It is evident from the mechanistic studies that the carcinogens have a stronger tendency to mutate the genes like suppresser gene, a gene that encodes the receptor of the cell surface to the nucleus, thus, giving way to the proliferation of mutation leading to neoplastic cells. In this analysis article, we have discussed molecular mechanics that can cause cancer by nitrosamines such as nicotine-derived nitrosamine ketone and NNN regarding a variety of significant cigarette combustion carcinogens and the effort to introduce a different dimensional approach to the prevention of cancer, by understanding the perspective of various treatments.

Keywords: 4(methylnitrosomine)-1-(3-pyridyl)-1-butano nitrosonornicotine, Carcinogen, Cigarette, Mutant, Nitrosamine ketone, P53, Tumor

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S, V., C. DHARMASHEKARA, A. PRASAD, K. S. PRASAD, C. SRINIVASA, K. GC, P. B. S. SETTY, and C. SHIVAMALLU. “SMOKING CARCINOGENS AND LUNG CANCER – A REVIEW”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 14, no. 1, Jan. 2021, pp. 5-12, doi:10.22159/ajpcr.2021.v14i1.39811.
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