ANTIFUNGAL AND ANTIBIOFILM ACTIVITY OF 2-BROMO-N-PHENYLCETAMIDE AGAINST CRYPTOCOCCUS NEOFORMANS

Abstract

Objective: This study aimed to evaluate the antifungal and antibiofilm of 2-bromo-N-phenylacetamide (A1Br) against Cryptococcus neoformans in vitro.


Methods: The compound was characterized by infrared and 1H-nuclear magnetic resonance spectrometry data. Minimum inhibitory concentration (MIC) was determined using the plate dilution method and biofilm formation inhibition of the crystal violet assay.


Results: A1Br inhibited the growth of C. neoformans with MIC of 0.25 and 0.5 μg/ml and has good antibiofilm activity MIC ×4, with ≥80% inhibition growth.


Conclusions: Thus, A1Br shows potential antifungal and antibiofilm agents for the treatment of infections caused by C. neoformans, as well as the eradication of cryptococcal colonization of medical prosthetic devices.

Keywords: Antifungal, Biofilm, 2-bromo-N-phenylcetamide, Cryptococcus neoformans, in vitro

Author Biography

ABRAHÃO ALVES DE OLIVEIRA-FILHO, Department of , Federal University of Campina Grande, Patos, Brazil.

3 Academic Unit of Biological Sciences, Health Center and Rural Technology, Federal University of Campina Grande, Patos, Paraíba, Brazil.

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DE MELO, T. R., L. V. CORDEIRO, H. D. DA SILVA SOUZA, P. F. DE ATHAYDE-FILHO, A. A. DE OLIVEIRA-FILHO, S. B. FERREIRA, and E. D. OLIVERIA LIMA. “ANTIFUNGAL AND ANTIBIOFILM ACTIVITY OF 2-BROMO-N-PHENYLCETAMIDE AGAINST CRYPTOCOCCUS NEOFORMANS”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 13, no. 12, Dec. 2020, pp. 173-6, doi:10.22159/ajpcr.2020.v13i12.39834.
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