ANTIFUNGAL AND ANTIBIOFILM ACTIVITY OF 2-BROMO-N-PHENYLCETAMIDE AGAINST CRYPTOCOCCUS NEOFORMANS

THAMARA RODRIGUES DE MELO; LAÍSA VILAR CORDEIRO; HELIVALDO DIÓGENES DA SILVA SOUZA; PETRÔNIO FILGUEIRAS DE ATHAYDE-FILHO; ABRAHÃO ALVES DE OLIVEIRA-FILHO; SÁVIO BENVINDO FERREIRA; EDELTRUDES DE OLIVERIA LIMA

doi:10.22159/ajpcr.2020.v13i12.39834

Authors

THAMARA RODRIGUES DE MELO Department of Pharmaceutical Science, Health Sciences Center, Federal University of Paraíba, João Pessoa, Paraíba, Brazil. https://orcid.org/0000-0001-6540-9585
LAÍSA VILAR CORDEIRO Department of Pharmaceutical Science, Health Sciences Center, Federal University of Paraíba, João Pessoa, Paraíba, Brazil. https://orcid.org/0000-0002-8884-7331
HELIVALDO DIÓGENES DA SILVA SOUZA Department of Chemistry, Exact and Natural Sciences Center, Federal University of Paraíba, João Pessoa, Brazil. https://orcid.org/0000-0002-1708-4066
PETRÔNIO FILGUEIRAS DE ATHAYDE-FILHO Department of Chemistry, Exact and Natural Sciences Center, Federal University of Paraíba, João Pessoa, Brazil. https://orcid.org/0000-0003-0982-8261
ABRAHÃO ALVES DE OLIVEIRA-FILHO Department of , Federal University of Campina Grande, Patos, Brazil. https://orcid.org/0000-0002-7466-9933
SÁVIO BENVINDO FERREIRA Federal University of Campina Grande, Cajazeiras, Brazil. https://orcid.org/0000-0001-8838-4755
EDELTRUDES DE OLIVERIA LIMA Department of Pharmaceutical Science, Health Sciences Center, Federal University of Paraíba, João Pessoa, Paraíba, Brazil. https://orcid.org/0000-0002-9547-0886

DOI:

https://doi.org/10.22159/ajpcr.2020.v13i12.39834

Keywords:

Antifungal, Biofilm, 2-bromo-N-phenylcetamide, Cryptococcus neoformans, in vitro

Abstract

Objective: This study aimed to evaluate the antifungal and antibiofilm of 2-bromo-N-phenylacetamide (A1Br) against Cryptococcus neoformans in vitro.

Methods: The compound was characterized by infrared and 1H-nuclear magnetic resonance spectrometry data. Minimum inhibitory concentration (MIC) was determined using the plate dilution method and biofilm formation inhibition of the crystal violet assay.

Results: A1Br inhibited the growth of C. neoformans with MIC of 0.25 and 0.5 μg/ml and has good antibiofilm activity MIC ×4, with ≥80% inhibition growth.

Conclusions: Thus, A1Br shows potential antifungal and antibiofilm agents for the treatment of infections caused by C. neoformans, as well as the eradication of cryptococcal colonization of medical prosthetic devices.

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Author Biography

ABRAHÃO ALVES DE OLIVEIRA-FILHO, Department of , Federal University of Campina Grande, Patos, Brazil.

³ Academic Unit of Biological Sciences, Health Center and Rural Technology, Federal University of Campina Grande, Patos, Paraíba, Brazil.

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