Stability Indicating Method Development and Validation of Fimasartan by RP-HPLC in Bulk and Pharmaceutical Dosage form.

Method Development and Validation of Fimasartan by RP-HPLC in Bulk and Pharmaceutical Dosage form.

  • UTTAM PRASAD PANIGRAHY UTTAM CMR COLLEGE OF PHARMACY

Abstract

Objective: A rapid, sensitive and specific reverse phase High performance liquid Chromatography (RP-HPLC) method was developed for the estimation of Fimasartan in bulk and pharmaceutical dosage form.


Method: The RP-HPLC analysis was performed isocratically on a Primacel C18 column (150 mm×4.6mm internal diameter, 5μm particle size) using mobile phase of composition Acetonitrile and 0.1% orthophosphoric Acid in 80:20, v/v proportions with a flow rate of 0.8ml/min.


Results: The analyte was monitered with UV- detector at 265nm. In the developed method Fimasartan elutes at a typical retention time of 2.4min. The proposed method is having linearity in the concentration ranging from 5-30μg/ml of Fimasartan.


Conclusion: The method was statistically validated and had been applied to analysis of the drug in bulk and pharmaceutical dosage form.

Keywords: Fimasartan, RP-HPLC, C18 column.

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UTTAM, U. P. P. “Stability Indicating Method Development and Validation of Fimasartan by RP-HPLC in Bulk and Pharmaceutical Dosage form.: Method Development and Validation of Fimasartan by RP-HPLC in Bulk and Pharmaceutical Dosage Form.”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 14, no. 2, Feb. 2021, https://innovareacademics.in/journals/index.php/ajpcr/article/view/39919.
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