OPTIMIZATION AND CHARACTERIZATION OF FORMULATION SELF NANOEMULSIFYING DRUG DELIVERY SYSTEM (SNEDDS) ETHANOL EXTRACT OF ROMANG PARANG LEAVES (Boehmeria virgata)

  • Magfirah sekolah tinggi ilmu farmasi pelita mas palu
  • Indah Kurnia Utami College of Pharmaceutical Sciences Pelita Mas Palu

Abstract

Objective : Parang romang (Boehmeria virgata) is one of the traditional medicines that is used empirically by Makassar tribal healers, South Sulawesi as an anti-tumor drug. This traditional medicine contains secondary metabolites such as alkaloids, flavonoids, tannins and saponins. However, secondary metabolites of those leaves extract have low solubility in water. Hence, to be formula Self-Nanoemulsifying Drug Delivery System (SNEDDS) is one of the solutions to increase the extract solubility.


Method : The Optimazation of  two formula optimum SNEDDS parang romang leaves (T80PGMZ, T20PGMZ) were using the simple lattice design (SLD) method will give 28 SNEDDS formula parang romang leaves each of which the formula is tested for its characteristics as a critical point include emulsification time, % transmittance, drug loading, particle size, zeta potential, polydipersity index and morfology particle.


Result : The results of SNEDDS characterization obtained the optimum formula T80PGMZ with emulsification time 12.6 seconds, % transmittance 92.21%, drug loading  68.21 ppm, particle size 370.26 nm, zeta potential -31.4 mV, polydipersity index of 0.615 and regular particle morphology with spherical chunks at a magnification of 10,000 times with a particle size of 10 µm.


Conclusion : SNEDDS of parang romang leaves extracts that used olive oil as oil phase, tween 80 as surfactant, and propylene glycol as the co-surfactant provided nanoemulsion with good characteristics


Keywords : Optimization, Characterization, Self-Nanoemulsifying Drug Delivery System,  Ethanol Extract Of Parang Romang  Leaves.

Keywords: Optimization, Characterization, Self-Nanoemulsifying Drug Delivery System, Ethanol Extract Of Parang Romang Leaves.

References

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Magfirah, and I. K. Utami. “OPTIMIZATION AND CHARACTERIZATION OF FORMULATION SELF NANOEMULSIFYING DRUG DELIVERY SYSTEM (SNEDDS) ETHANOL EXTRACT OF ROMANG PARANG LEAVES (Boehmeria Virgata)”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 14, no. 1, Jan. 2021, pp. 207-12, https://innovareacademics.in/journals/index.php/ajpcr/article/view/39922.
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