ASSESSMENT OF COMPARATIVE PATIENT SATISFACTION AND SIDE-EFFECTS ASSOCIATED WITH TAMSULOSIN VERSUS SILODOSIN THERAPY IN BENIGN PROSTATE HYPERPLASIA

  • VINEETH JAYAKUMAR Kerala University of Health Sciences

Abstract

Objective: The aim of our study is to assess the comparative patient satisfaction and side-effects of the currently prescribed drugs- Tamsulosin and Silodosin for BPH.


Method: A Prospective study was conducted in a total of 110 BPH patients from the department of Urology for a period of 6 months. 55 patients in each group received Silodosin 8 mg or Tamsulosin 0.4 mg once daily. Data was collected by using a suitably designed proforma and the patient satisfaction was assessed with Patient’s Perception of Study Medication (PPSM) scale. International Prostate Symptom Score (IPSS) was used for assessing severity of symptoms.


Result: The current study found that the treatment had a significant effect on improving scores of PPSM and IPSS at which all changes were significant at P values <0.01(paired t-test). An independent t-test showed that Silodosin group has a greater improvement in PPSM scores- PPSM Total by 40.4%, PPSM Global by 43.7% and PPSM Pain by 0.39% which was supported by corresponding decline in IPSS scores. The reported side effects of Tamsulosin were headache (5.5%), dizziness (5.5%), dry mouth (3.6%), postural hypotension (14.4%) and those reported for Silodosin were myalgia (5.5%), dizziness (7.3%), diarrhea (1.8%) and postural hypotension (10.9%).


 Conclusion: Patient satisfaction was improved by both the alpha blockers but Silodosin showed a significantly greater increase in patient satisfaction than Tamsulosin. Thus, Silodosin is the better drug of choice.

Keywords: Benign Prostate Hyperplasia, International Prostate Symptom Score, Patient Perception of Study Medication, Silodosin, Tamsulosin.
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JAYAKUMAR, V. “ASSESSMENT OF COMPARATIVE PATIENT SATISFACTION AND SIDE-EFFECTS ASSOCIATED WITH TAMSULOSIN VERSUS SILODOSIN THERAPY IN BENIGN PROSTATE HYPERPLASIA”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 14, no. 2, Jan. 2021, https://innovareacademics.in/journals/index.php/ajpcr/article/view/39931.
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