STATUS OF URINARY 15-F2t-ISOPROSTANE LEVELS IN GTCS PATIENTS WITH LEVETIRACETAM IN A TERTIARY CARE HOSPITAL

Abstract

ABSTRACT:

Objectives: To analyse urinary 15-2t-isoprostane levels in epileptic patients with Levetiracetam. To compare the urinary 15-2t-isoprostane levels between the different age groups, smokers and alcoholics.

Materials and Methods: The study was conducted in a tertiary care hospital. Urinary 15-2t-isoprostane levels were assayed in epileptic patients taking Levetiracetam. 20 patients were recruited. Urinary levels of 15-F2t-isoprostane determined by ELISA. The patient’s age, gender, height, weight, smoking and alcoholic history was collected using proforma. Statistical analysis of data was performed using SPSS version 23.0.

Results: A total of 20 participants recruited for the study. Among these 70% were males, 30% were females. The mean weight and height was more in males compared to females. The mean 15-F2t-isoprostane level was significantly higher in males compared to females. More than 40 % of the participants were in the age group greater than 40 years. However the Mean urinary 15-F2t-isoprostane level is higher in the age group of 19-30 years. Only 20% of the participants were smokers and alcoholics. Non-smokers and no-alcoholics had higher urinary 15-F2t-isoprostane levels compared to smokers and alcoholics.

Conclusion: The urinary 15-F2t-isoprostane levels were more in males, the age group of 19-30 years, non-smokers and non-alcoholics. However the levels are lesser when compared to earlier meta-analysis study. There is need for further studies with more sample size and correlation of Levetiracetam and urinary 15-F2t-isoprostane levels.