REVIEW OF THE TAXONOMY, ETHNOBOTANY, PHYTOCHEMISTRY, PHYTOTHERAPY AND PHYTOTOXICITY OF GERMANDER PLANT (TEUCRIUM POLIUM L.)

Authors

  • Nidal AMIN Jaradat An-Najah National UniversityFaculty of Medicine and Health SciencesDepartment of Pharmacy

Abstract

 

Medicinal plants and phytogenic products have used for treatment of various diseases from ancient times in the folklore medicine all over the world.
Crude plants extracts are now considered a valuable source for natural products used in the development of medicines against various diseases, for
the development of pharmaceutical preparations, and for novel biomedical researches.
Germander (Teucrium polium L.) is a shrubby plant widely distributed in the mountains, hills and deserts of the Mediterranean regions and
considered one of the most useful traditional medicinal plants in Palestine and other Middle Eastern countries. It has been used for centuries in
the ethnopharmacology for the treatments of many pathophysiological conditions, such as diabetes, gastrointestinal disorders, rheumatism,
inflammations, also used as diuretic, antipyretic, tonic, diaphoretic, analgesic, antihyperlipidemic and other disorders. During the last five decades,
apart from the phytochemical characterization of the components of the T. polium plant, there has been significant interest in the medicinal applications
and biological activity of this plant. This review summarizes more than 50 years of scientific knowledge of Germander. It provides an overview on
its taxonomy, biological activities, the most well-known isolated compounds from all the plants parts, clinical studies, and pharmacological activities.
Evidence-based medicinal applications of the plant extracts have been discussed along with their safety evaluation, especially the recent evidence for
hepatotoxicity secondary to the long term use of this plant.

Keywords: Teucrium polium L, Biological activity, Ethnobotany, Phytochemical constituents, Phytotherapy, Phytotoxocity.

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Author Biography

Nidal AMIN Jaradat, An-Najah National UniversityFaculty of Medicine and Health SciencesDepartment of Pharmacy

Head of the Pharmaceutical Chemistry and Technology Division

An-Najah National University Faculty of Medicine and Health Sciences Department of Pharmacy

References

Davis SC, Perez R. Cosmeceuticals and natural products: wound healing. Clinics in dermatology 2009; 27: 502-6.

Uniyal SK, Singh K, Jamwal P, Lal B. Traditional use of medicinal plants among the tribal communities of Chhota Bhangal, Western Himalaya. Journal of Ethnobiology and Ethnomedicine 2006; 2: 14.

Losoya Z. Synthetic Drugs-Emergence, Legislation, and the Criminal and Legal Aftermath of Broad Regulation. SMUL Rev 2013; 66: 401.

McKenna J. Natural Alternatives to Antibiotics: Using Nature's Pharmacy to Help Fight Infections. Penguin, 1998.

Doughari J. Antimicrobial activity of Tamarindus indica Linn. Tropical Journal of Pharmaceutical Research 2007; 5: 597-603.

El Astal Z, Ashour A, Kerrit A. Antimicrobial activity of some medicinal plant extracts in Palestine. Pak J Med Sci 2005; 21: 187-93.

Abu-Irmaileh BE, Afifi FU. Herbal medicine in Jordan with special emphasis on commonly used herbs. Journal of Ethnopharmacology 2003; 89: 193-7.

Newman DJ, Cragg GM. Natural products as sources of new drugs over the 30 years from 1981 to 2010. Journal of natural products 2012; 75: 311-35.

Patwardhan B, Vaidya AD, Chorghade M. Ayurveda and natural products drug discovery. CURRENT SCIENCE-BANGALORE- 2004; 86: 789-99.

Gurib-Fakim A. Medicinal plants: traditions of yesterday and drugs of tomorrow. Molecular aspects of Medicine 2006; 27: 1-93.

Patwardhan B, Mashelkar RA. Traditional medicine-inspired approaches to drug discovery: can Ayurveda show the way forward? Drug discovery today 2009; 14: 804-11.

Palevitch D, Price R, Yaniv Z. Medicinal plants of the Holy Land. Modan Publishing House, 2000.

Zargari A, MacDonald K. A History and Philosophy of Technology Education. Technology Teacher 1994; 53: 7-11.

Pedersen JA. Distribution and taxonomic implications of some phenolics in the family Lamiaceae determined by ESR spectroscopy. Biochemical systematics and Ecology 2000; 28: 229-53.

Evans WC. Trease and Evans' pharmacognosy. Elsevier Health Sciences, 2009.

Yazdi FT, Behbahani BA. Antimicrobial effect of the aqueous and ethanolic Teucrium polium L. extracts on gram positive and gram negative bacteria in vitroâ€. Journal of Paramedical Sciences 2013; 4.

The plant list. The Plant List.org Version 1.1.

Bedevian AK. Illustrated polyglottic dictionary of plant names. Illustrated polyglottic dictionary of plant names 1936.

McClintock E, Epling C. A revision of Teucrium in the New World, with observations on its variation, geographical distribution and history. Brittonia 1946; 5: 491-510.

Seyyednejad S, Motamedi H. A review on native medicinal plants in Khuzestan, Iran with antibacterial properties. International Journal of Pharmacology 2010; 6: 551-60.

Akhani H, Mahdavi P, Noroozi J, Zarrinpour V. Vegetation Patterns of the Irano-Turanian Steppe along a 3,000 m Altitudinal Gradient in the Alborz Mountains of Northern Iran. Folia Geobotanica 2013; 48: 229-55.

Barceloux DG. Medical toxicology of natural substances: foods, fungi, medicinal herbs, plants, and venomous animals. John Wiley & Sons, 2008.

Cakir A, Duru ME, Harmandar M, et al. Volatile constituents of Teucrium polium L. from Turkey. Journal of essential oil research 1998; 10: 113-5.

Eikani MH, Goodarznia I, Mirza M. Comparison between the Essential Oil and Supercritical Carbon Dioxide Extract of Teucrium polium L. Journal of essential oil research 1999; 11: 470-2.

Kovacevic NN, Lakusic BS, Ristic MS. Composition of the essential oils of seven Teucrium species from Serbia and Montenegro. Journal of essential oil research 2001; 13: 163-5.

Perez-Alonso M, Velasco-Negueruela A, Lopez-Saez J. The essential oils of two Iberian Teucrium species. Journal of essential oil research 1993; 5: 397-402.

Sarer E, Konuklugil B, Eczacilik F. Investigation of the volatile oil of Teucrium polium L. Turkish Tipve Eczacillk Dergisi 1987; 11: 317-25.

Aburjai T, Hudaib M, Cavrini V. Composition of the essential oil from Jordanian germander (Teucrium polium L.). Journal of essential oil research 2006; 18: 97-9.

Kabouche A, Kabouche Z, Ghannadi A, Sajjadi S. Analysis of the Essential Oil of Teucrium polium ssp. aurasiacum from Algeria. Journal of essential oil research 2007; 19: 44-6.

Hassan M, Muhtadi F, Alâ€Badr A. GLCâ€mass spectrometry of Teucrium polium oil. Journal of pharmaceutical sciences 1979; 68: 800-1.

Carreiras MC, Rodríguez B, Piozzi F, et al. A chlorine-containing and two 17β-< i> neo-clerodane diterpenoids from< i> Teucrium polium subsp.< i> Vincentinum. Phytochemistry 1989; 28: 1453-61.

Capasso F, Cerri R, Morrica P, Senatore F. Chemical composition and anti-inflammatory activity of an alcoholic extract of Teucrium polium L. Bollettino della Societa italiana di biologia sperimentale 1983; 59: 1639-43.

Harborne JB, Tomás-Barberán FA, Williams CA, Gil MI. A chemotaxonomic study of flavonoids from european< i> teucrium species. Phytochemistry 1986; 25: 2811-6.

Sharififar F, Dehghn-Nudeh G, Mirtajaldini M. Major flavonoids with antioxidant activity from< i> Teucrium polium L. Food Chemistry 2009; 112: 885-8.

Bianco A, Ramunno A, Serrilli AM, et al. Phytochemical characters of teucrium marum from Sardinia: an endemic plant. Natural product research 2004; 18: 557-64.

Elmasri WA, Hegazy M-EF, Aziz M, et al. Biofilm blocking sesquiterpenes from< i> Teucrium polium. Phytochemistry 2014; 103: 107-13.

Bahramikia S, Yazdanparast R. Phytochemistry and medicinal properties of Teucrium polium L.(Lamiaceae). Phytotherapy Research 2012; 26: 1581-93.

Jaradat N. Ethnopharmacological survey of natural products in palestine. An-Najah Univ J Res(N Sc) 2005; 19.

Essawi T, Srour M. Screening of some Palestinian medicinal plants for antibacterial activity. Journal of Ethnopharmacology 2000; 70: 343-9.

Kamel A. 7-epi-Eudesmanes from Teucrium polium. Journal of natural products 1995; 58: 428-31.

Said O, Khalil K, Fulder S, Azaizeh H. Ethnopharmacological survey of medicinal herbs in Israel, the Golan Heights and the West Bank region. Journal of Ethnopharmacology 2002; 83: 251-65.

Tariq M, Ageel A, Al-Yahya M, et al. Anti-inflammatory activity of Teucrium polium. International journal of tissue reactions 1988; 11: 185-8.

Gharaibeh MN, Elayan HH, Salhab AS. Hypoglycemic effects of< i> Teucrium polium. Journal of Ethnopharmacology 1988; 24: 93-9.

Esmaeili MA, Yazdanparast R. Hypoglycaemic effect of< i> Teucrium polium: studies with rat pancreatic islets. Journal of Ethnopharmacology 2004; 95: 27-30.

Yazdanparas R, Esmaeili MA, Ashrafi Helan J. Teucrium polium extract effects pancreatic function of streptozotocin diabetic rats: A histopathological examination. Iranian biomedical journal 2005; 9: 81-5.

Hasanein P, Shahidi S. Preventive effect of Teucrium polium on learning and memory deficits in diabetic rats. Medical science monitor: international medical journal of experimental and clinical research 2012; 18: BR41.

Ardestani A, Yazdanparast R, Jamshidi S. Therapeutic effects of Teucrium polium extract on oxidative stress in pancreas of streptozotocin-induced diabetic rats. Journal of medicinal food 2008; 11: 525-32.

Tatar M, Qujeq D, Feizi F, et al. Effects of Teucrium Polium Aerial Parts extract on oral glucose tolerance tests and pancreas histopathology in Streptozocin-induced diabetic rats. International journal of molecular and cellular medicine 2012; 1: 44.

Djeridane A, Yousfi M, Nadjemi B, et al. Antioxidant activity of some Algerian medicinal plants extracts containing phenolic compounds. Food Chemistry 2006; 97: 654-60.

Hasani P, Yasa N, Vosough-Ghanbari S, et al. In vivo antioxidant potential of Teucrium polium, as compared to α-tocopherol. Acta pharmaceutica 2007; 57: 123-9.

Qabaha KI. Antimicrobial and free radical scavenging activities of five Palestinian medicinal plants. African Journal of Traditional, Complementary and Alternative medicines 2013; 10: 101-8.

Rajabalian S. Methanolic extract of Teucrium polium L. potentiates the cytotoxic and apoptotic effects of anticancer drugs of vincristine, vinblastine and doxorubicin against a panel of cancerous cell lines. Exp Oncol 2008; 30: 133-8.

Aggelis G, Athanassopoulos N, Paliogianni A, Komaitis M. Effect of a Teucrium polium L. extract on the growth and fatty acid composition of Saccharomyces cerevisiae and Yarrowia lipolytica. Antonie van Leeuwenhoek 1998; 73: 195-8.

Alwan A, Jawad A-LM, Albana A, Ali K. Antiviral activity of some Iraqi indigenous plants. Pharmaceutical Biology 1988; 26: 107-11.

Autore G, Capasso F, De Fusco R, et al. Antipyretic and antibacterial actions of Teucrium polium (L.). Pharmacological research communications 1984; 16: 21-9.

Rojas A, Hernandez L, Pereda-Miranda R, Mata R. Screening for antimicrobial activity of crude drug extracts and pure natural products from Mexican medicinal plants. Journal of Ethnopharmacology 1992; 35: 275-83.

Sarac N, Ugur A. Antimicrobial activities and usage in folkloric medicine of some Lamiaceae species growing in Mugla, Turkey. EurAsian Journal of BioSciences 2007; 4: 28-37.

Darabpour E, Motamedi H, Nejad SMS. Antimicrobial properties of< i> Teucrium polium against some clinical pathogens. Asian Pacific Journal of Tropical Medicine 2010; 3: 124-7.

Abdollahi M, Karimpour H, Monsef-Esfehani HR. Antinociceptive effects of< i> Teucrium polium L. total extract and essential oil in mouse writhing test. Pharmacological Research 2003; 48: 31-5.

Kamel A, Sandra P. Gas chromatography—mass spectrometry analysis of the volatile oils of two< i> Teucrium polium varieties. Biochemical systematics and Ecology 1994; 22: 529-32.

Khleifat K, SHAKHANBEH J, Tarawneh K. The chronic effects of Teucrium polium on some blood parameters and histopathology of liver and kidney in the rat. Turkish journal of Biology 2002; 26: 65-71.

Panovska T, Kulevanova S, Gjorgoski I, et al. Hepatoprotective effect of the ethyl acetate extract of Teucrium polium L. against carbontetrachloride-induced hepatic injury in rats. Acta pharmaceutica 2007; 57: 241-8.

Rasekh H, Khoshnood-Mansourkhani M, Kamalinejad M. Hypolipidemic effects of< i> Teucrium polium in rats. Fitoterapia 2001; 72: 937-9.

Movahedi A, Basir R, Rahmat A, et al. Remarkable Anticancer Activity of Teucrium polium on Hepatocellular Carcinogenic Rats. Evidence-Based Complementary and Alternative Medicine 2014; 2014.

Khoshnood-Mansoorkhani MJ, Moein MR, Oveisi N. Anticonvulsant activity of Teucrium polium against seizure induced by PTZ and MES in mice. Iranian journal of pharmaceutical research: IJPR 2010; 9: 395.

Ansari M, Sharififar F, Kazemipour M, et al. Teucrium polium L. extract adsorbed on zinc oxide nanoparticles as a fortified sunscreen. International journal of pharmaceutical investigation 2013; 3: 188.

Forouzandeh H, Azemi ME, Rashidi I, et al. Study of the Protective Effect of Teucrium polium L. Extract on Acetaminophen-Induced Hepatotoxicity in Mice. Iranian journal of pharmaceutical research: IJPR 2013; 12: 123.

Orhan I, Aslan M. Appraisal of scopolamine-induced antiamnesic effect in mice and< i> in vitro antiacetylcholinesterase and antioxidant activities of some traditionally used Lamiaceae plants. Journal of Ethnopharmacology 2009; 122: 327-32.

Suleiman M-S, Abdul-Ghani A-S, Al-Khalil S, Amin R. Effect of< i> Teucrium polium boiled leaf extract on intestinal motility and blood pressure. Journal of Ethnopharmacology 1988; 22: 111-6.

Malakov PY, Papanov GY. Furanoid diterpenes from< i> Teucrium polium. Phytochemistry 1983; 22: 2791-3.

Aqel M, Gharaibeh M, Salhab A. The calcium antagonistic effect of the volatile oil of Teucrium polium. Pharmaceutical Biology 1990; 28: 201-7.

Starakis I, Siagris D, Leonidou L, et al. Hepatitis caused by the herbal remedy Teucrium polium L. European journal of gastroenterology & hepatology 2006; 18: 681-3.

Mattéi A, Pierre R, Didier S, et al. Liver transplantation for severe acute liver failure after herbal medicine:(Teucrium polium) administration. Journal of hepatology 1995; 22: 597.

Published

01-03-2015

How to Cite

Jaradat, N. A. “REVIEW OF THE TAXONOMY, ETHNOBOTANY, PHYTOCHEMISTRY, PHYTOTHERAPY AND PHYTOTOXICITY OF GERMANDER PLANT (TEUCRIUM POLIUM L.)”. Asian Journal of Pharmaceutical and Clinical Research, vol. 8, no. 2, Mar. 2015, pp. 13-19, https://journals.innovareacademics.in/index.php/ajpcr/article/view/4058.

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Review Article(s)