TREATMENT PATTERN OF COVID-19 PATIENTS IN A TERTIARY CARE TEACHING HOSPITAL OF NORTHERN INDIA

Authors

  • SUMAN LATA Department of Pharmacology, Government Medical College, Kathua, Maharashtra, India.
  • VIJAY KHAJURIA Department of Pharmacology, Government Medical College, Kathua, Maharashtra, India.
  • VINEETA SAWHNEY Department of Pharmacology, Government Medical College, Kathua, Maharashtra, India.

DOI:

https://doi.org/10.22159/ajpcr.2021.v14i11.42345

Keywords:

Coronavirus disease-19, Remdesivir, Steroids

Abstract

Objective: The objective of present study was to assess the treatment pattern in the COVID-19 patients.

Methods: The present study was a hospital-based prospective observational conducted in Government Medical College Kathua (UT Jammu and Kashmir) on COVID-19 positive confirmed cases from December 2020 to January 2021. Consent was taken from patients who were willing to participate in the study. The details of presenting complaints and treatment received by them and outcome of management was recorded and evaluated from their treatment files.

Results: A total 56 patients of COVID-19 were enrolled for the study. Majority of them were males (60.71%) and maximum of the patients between 18 and 60 years constituted 69.6%. COPD (28.5%), severe anemia (21.42%), and diabetes mellitus and hypertension (19.64% each) were common comorbidities. Sore throat, dry cough, and breathlessness were common presenting symptoms. Pattern of antibiotics and antivirals revealed that azithromycin was frequently prescribed (87.5%) followed by hydroxychloroquine (44.64%), linzolid (21.42%), ceftriaxone (19.64%), and remdesivir (14.28%). Majority of patients (>50%) were treated with steroids, while all patients received multivitamins and Vitamin C (100%) and nearly 40% were administered zinc therapy.

Conclusions: Azithromycin, hydroxyquinine, remdesivir, and steroids were frequently prescribed in patients of COVID-19. Steroids were administered in oral, inhaler or in injection forms. Multivitamins including Vitamin C were given to all patients. Most of patients had comorbidities including COPD, diabetes mellitus type 2 and severe anemia.

Downloads

Download data is not yet available.

References

Phua J, Weng L, Ling L, Egi M, Lim CM, Divatia JV, et al. Intensive care management of Coronavirus disease 2019 (COVID-19): Challenges and recommendations. Lancet Respir Med 2020;5:506-17. DOI: https://doi.org/10.1016/S2213-2600(20)30161-2

Morens DM, Daszak P, Taubenberger JK. Escaping Pandora’s box-another novel coronavirus. N Engl J Med 2020;382:1293-5. DOI: https://doi.org/10.1056/NEJMp2002106

Nicola M, O’Neill N, Sohrabi C, Khan M, Agha M, Agha R. Evidence based management guideline for the COVID-19 pandemic-reviewarticle. Int J Surg 2020;77:206-16. DOI: https://doi.org/10.1016/j.ijsu.2020.04.001

India Most Infected by COVID-19 among Asian Countries Leaves Turkey Behind, Hindustan Times; 2020.

WHO Global, India Date Updated 2021/2/22; 2021.

Jain VK, Iyengar K, Vaish A, Vaishya R. Differential mortality in COVID-19 patients from India and western countries. Diabetes Metab Syndr 2020;14:1037-41. DOI: https://doi.org/10.1016/j.dsx.2020.06.067

Transmission of COVID-19; 2021. Available from: https://www.ecdced [Last accessed on 2021 Sep 07].

Bhagat RK, Linden PF. Displacement ventilation: A viable ventilation strategy for makeshift hospitals and public buildings to contain COVID-19 and other airborne diseases. R Soc Open Sci 2020;7:200680. DOI: https://doi.org/10.1098/rsos.200680

Centres for Disease Control and Prevention; 2020. Available from: https://www.cdc.gov/coronavirus/2019-ncov/prevent-getting-sick/prevention.html?cdc_aa_refval=https%3a%2f%2fwww.cdc. gov%2fcoronavirus%2f2019

COVID-19 Vaccine Covishield Gets Approval from DCGI ‘Sexpert Panel’, The Hindu; 2021.

Astra Zaneca’s COVID-19 Vaccine Authorised for Emergency Supply in UK. AstraZeneca. Expert Panel Recomends Bharat Biotech Scovaxin For Restricted Emergency Use, News 18; 2021.

Hasan SN, Srivstava A, Bihari A, Singh PK. Management prospective of COVID-19 patients from L1 till L3 Hospital: An observational study. Natl J Physiol Pharmacol 2020;10:1002-5. DOI: https://doi.org/10.5455/njppp.2020.10.07195202026072020

Lin KJ, Schneeweiss S, Helen T, D’Andrea E, Liu J, Lii J, Murphy SN, et al. Pharmacotherapy for hospitalized patients with COVID-19: Treatment patterns by disease severity. Drug 2020;80:1961-72. DOI: https://doi.org/10.1007/s40265-020-01424-7

Ghosh A, Nundy S, Mallick TK. How India is dealing with COVID-19 pandemic. Sensors Int 2020;1:100021. DOI: https://doi.org/10.1016/j.sintl.2020.100021

Alqahtani JS, Oyelade T, Aldhahir AM, Alghamdi SM, Almehmadi M, Alqahtani AS, et al. Prevalence, severity and mortality associated with COPD and smoking in patients with COVID-19: A rapid systematic review and meta-analysis. PLoS One 2020;15:e0233147. DOI: https://doi.org/10.1371/journal.pone.0233147

Hemauer SJ, Kingeter AJ, Han X, Shotwell MS, Pandharipande PP, Weavind LM. Daily lowest hemoglobin and risk of organ dysfunctions in critically ill patients. Crit Care Med 2017;45:e479-84. DOI: https://doi.org/10.1097/CCM.0000000000002288

Longo M, Caruso P, Maiorino MI, Bellastella G, Giugliano D, Esposito K. Treating Type 2 diabetes in COVID-19 patients: The potential benefits of injective therapies. Cardiovasc Diabetol 2020;19:115. DOI: https://doi.org/10.1186/s12933-020-01090-9

Abdi AA, Jalilian BM, Sarbarzeh BP, Vlaisavljevic CZ. Diabetes and COVID-19: A systematic review on the current evidences. Diabetes Res Clin Pract 2020;166:108347. DOI: https://doi.org/10.1016/j.diabres.2020.108347

Shang L, Shao M, Guo Q, Shi J, Zhao Y, Xiaokereti J, Tang B. Diabetes Mellitus is associated with severe infection and mortality in patients with COVID-19: A systematic review and meta-analysis. Arch Med Res 2020;51:700-9. DOI: https://doi.org/10.1016/j.arcmed.2020.07.005

Saha S, Al-Rifai RH, Saha S. Diabetes prevalence and mortality in COVID-19 patients: A systematic review, meta-analysis, and meta-regression. J Diabetes Metab Disord 2021;31:1-12. DOI: https://doi.org/10.1007/s40200-021-00779-2

Palaiodimos L, Chamorro-Pareja N, Karamanis D, Li W, Zavras PD,Chang KM, et al. Diabetes is associated with increased risk for in-hospital mortality in patients with COVID-19: A systematic review and meta-analysis comprising 18, 506 patients. Hormones (Athens) 2021;20:305-14. DOI: https://doi.org/10.1007/s42000-020-00246-2

Rosenberg ES, Dufort EM, Udo T, Wilberschied LA, Kumar J, Tesoriero J, et al. Association of treatment with hydroxychloroquine or azithromycin with in-hospital mortality in patients with COVID-19 in New York state. JAMA 2020;323:2493-502. DOI: https://doi.org/10.1001/jama.2020.8630

Bull-Otterson L, Gray EB, Budnitz DS, Strosnider HM, Schieber LZ, Courtney J, et al. Hydroxychloroquine and chloroquine prescribing patterns by provider specialty following initial reports of potential Benefit for COVID-19 treatment-United States. MMWR Morb Mortal Wkly Rep 2020;69:1210-5. DOI: https://doi.org/10.15585/mmwr.mm6935a4

Gautret P, Lagier JC, Parola P, Hoang VT, Meddeb L, Mailhe M, et al. Hydroxychloroquine and azithromycin as a treatment of COVID-19: Results of an open-label non-randomized clinical trial. Int J Antimicrob Agents 2020;56:105949. DOI: https://doi.org/10.1016/j.ijantimicag.2020.105949

Molla MM, Yeasmin M, Islam K, Sharif MM, Amin MR, Nafisa T, et al. Antibiotic prescribing patterns at COVID-19 dedicated wards in Bangladesh: Findings from a single center study. Infect Prev Pract 2021;3:100134. DOI: https://doi.org/10.1016/j.infpip.2021.100134

26.Kawamura K, Ichikado K, Suga M, Yoshioka M. Efficacy of azithromycin for treatment of acute exacerbation of chronic fibrosing interstitial pneumonia: A prospective, open-label study with historical controls. Respiration 2014;87:478-84. DOI: https://doi.org/10.1159/000358443

Lamb YN. Remdesivir: First approval. Drugs 2020;80:1355-63. DOI: https://doi.org/10.1007/s40265-020-01378-w

Rai VK. COVID-19: Government Approves Plan to Increase Production of Remdesivir, Drug Cos to Cut Price; 2021.

Singh AK, Majumdar S, Singh R, Misra A. Role of corticosteroid in the management of COVID-19: A systemic review and a Clinician’s perspective. Diabetes Metab Syndr 2020;14:971-8. DOI: https://doi.org/10.1016/j.dsx.2020.06.054

Raju R, Prajith V, Biatris PS, Chander JS. Therapeutic role of corticosteroids in COVID-19: A systematic review of registered clinical trials. Futur J Pharm Sci 2021;7:67. DOI: https://doi.org/10.1186/s43094-021-00217-3

Michienzi SM, Badowski ME. Can vitamins and/or supplements provide hope against coronavirus? Drugs Context 2020;9:2020-5-7. DOI: https://doi.org/10.7573/dic.2020-5-7

Iranian Registry of Clinical Trials. Impact of Vitamin B, A, D, E, C Supplementation on Improvement and Mortality Rate in Patients with COVID-19 Admitted in Intensive Care Unit; 2020. Available from: https://www.en.irct.ir/trial/46838 [Last accessed on 2020 May 08].

Lee KC, Sewa DW, Phua GC. Potential role of statins in COVID-19. Int J Infect Dis 2020;96:615-7. DOI: https://doi.org/10.1016/j.ijid.2020.05.115

George PM, Barratt SL, Condliffe R, Desai RS, Devaraj A, Forrest I, et al. Respiratory follow-up of patients with COVID-19 pneumonia. Thorax 2020;75:1009-16. DOI: https://doi.org/10.1136/thoraxjnl-2020-215314

Published

07-11-2021

How to Cite

LATA, S., V. KHAJURIA, and V. SAWHNEY. “TREATMENT PATTERN OF COVID-19 PATIENTS IN A TERTIARY CARE TEACHING HOSPITAL OF NORTHERN INDIA”. Asian Journal of Pharmaceutical and Clinical Research, vol. 14, no. 11, Nov. 2021, pp. 48-51, doi:10.22159/ajpcr.2021.v14i11.42345.

Issue

Section

Original Article(s)