DESIGN AND EVALUATION OF TORSEMIDE CONTROLLED RELEASE MATRIX TABLETS
Objective: The controlled release Torsemide matrix tablets were prepared using different natural polymers in various proportions as release
retarding agents to control the torsemide release and to improve the patient compliance.
Methods: Torsemide matrix tablets were prepared by direct compression method. The matrix tablet is then evaluated for its thickness, hardness,
friability, weight variation, drug content and in vitro release. The compatibility of drug excipients was reviewed using Fourier transform infrared (FTIR)
and differential scanning calorimetry (DSC) studies.
Results: All the torsemide matrix formulations showed compliance with pharmacopoeial standards. Amongst all the formulations, formulation F9
containing pectin (10%) showed controlled drug release (99%) for 13 hrs, emerging as the best formulation. The formulation showed highest r2 value
of 0.9731 for zero order kinetics compared to first order kinetics indicating a drug release independent of concentration of the drug. Mechanism of
drug release of optimized formulation F-9 showed non-Fickian diffusion. FTIR and DSC studies indicated no chemical interaction between the drug
Conclusion: Hence, different natural polymers (guar gum, xanthan gum and pectin) in various proportions can be used to prepare matrix tablets of
Torsemide having controlled therapeutic effect with improved patient compliance.
Keywords: Torsemide, Guar gum, Xanthan gum, Pectin, Controlled Release, Matrix Tablets.
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