• Dr. Thilip Kumar Gnanadurai Chalmeda Anand Rao Institute of medical sciences. Bommakal Village Karim nagar , Telangana 5015001


Smoking, Electrocardiogram, Tp-e interval, Heart rate



Cigarette smoking, modifiable and preventable risk factor of death due to cardiovascular changes globally. One in every four death due to cardiovascular problem is due to smoking. Increase in the frequency of smoking has a direct effect on cardiovascular health. As the frequency increases, which alter the ventricular repolarization and sympathetic tone leads to ventricular arrhytmogenesis. Ventricular repolarization can be evaluated by QTc Interval, Tp-e interval, Tp-e/QTc ratio and we intended to record the acute effects of smoking among habitual smokers using Electrocardiogram.

Materials & Methods:-

40 healthy male volunteers who are smokers aged between 18-25 years were recruited in this study. All subjects were non alcoholics, non – tobacco chewers, took no drugs and had a uniform pattern of diet and activity. Acute effect of smoking on heart was determined by measuring the electrocardiographic parameter before and immediately after smoking a king size cigarette.


The analysis showed that there was statistically significant increase in heart rate immediately after smoking compared to baseline values in smokers. TP interval, and Tp-e interval were increased immediately after smoking and were highly significant


Our study has proven that there was a remarkable change in cardiac activity immediately after smoking. Tp-e Interval may serve as a better risk factor to predict sudden cardiac arrest in future especially in chronic smokers. Smoker’s heart is already injured due to its injurious chemicals, adding on to that every new cigarette increases the burden on cardiovascular health. So it’s never late to quit smoking rather than suffering from its injurious effect.


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Author Biography

Dr. Thilip Kumar Gnanadurai, Chalmeda Anand Rao Institute of medical sciences. Bommakal Village Karim nagar , Telangana 5015001

autonomic function test, hrv, pft, diabetes mellitus, related to blood parametre. etc...



Assistant Professor



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How to Cite

Gnanadurai, D. T. K. “ACUTE EFFECTS OF SMOKING ON VENTRICULAR REPOLARIZATION”. Asian Journal of Pharmaceutical and Clinical Research, vol. 15, no. 3, Jan. 2022,



Original Article(s)