MULTICOMPONENT ONE-POT SYNTHESIS OF NOVEL INDOLE ANALOGUES AS POTENT ANTIOXIDANT AGENTS

PARVEEN RAJESAB; PRABHAKAR W CHAVAN; JAISHREE G BADIGER; PRASHANT C HANAMSHETTY

doi:10.22159/ajpcr.2022.v15i6.43926

Authors

PARVEEN RAJESAB Department of Chemistry, H. K. E. Society’s Smt. Veeramma Gangasiri Degree College and P. G. Centre for Women, Kalaburagi, Karnataka, India.
PRABHAKAR W CHAVAN Department of Post-Graduate Studies and Research in Chemistry, Sahyadri Science College, Kuvempu University, Shivamogga, Karnataka, India. https://orcid.org/0000-0001-8326-7154
JAISHREE G BADIGER Department of Chemistry, H. K. E Society’s, M. S. Irani Degree College of Arts, Science and Commerce, Kalaburagi, Karnataka, India.
PRASHANT C HANAMSHETTY Department of Chemistry, Guru Nanak Degree College, Bidar, Karnataka, India.

DOI:

https://doi.org/10.22159/ajpcr.2022.v15i6.43926

Keywords:

Indole, Multicomponent reaction, Antioxidant, DNA cleavage activities

Abstract

Objective: The purpose of this study was to design and synthesize innovative multicomponent one-pot indole analogues that would be effective antioxidants for the body.

Methods: A novel series of indolyl-pyrimidine derivatives were synthesized and characterized by spectrum analysis, and their antioxidant activity and DPPH, total antioxidant capacity, ferric reducing antioxidant power methods, and DNA cleavage activity were examined.

Results: Compound 6a displayed promising free radical scavenging and total antioxidant properties. Compound 6b has demonstrated excellent ferric reducing activity, which is due to the presence of a “CH3” substitution at five position of indole. When compared to a standard DNA marker, compound 6a demonstrated the highest DNA cleavage activity at desired concentrations.

Conclusion: We have synthesized novel pyrimidine analogues containing an indole moiety to investigate drug-like molecules. We have devised that a method that is simple, multicomponent, has a short reaction time, and is ecologically benign.

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Author Biography

PRABHAKAR W CHAVAN, Department of Post-Graduate Studies and Research in Chemistry, Sahyadri Science College, Kuvempu University, Shivamogga, Karnataka, India.

Dr. Parveen R, She is mainly involved in Design, synthesis/characterization of entitled molecules and crafting and in the generation of new heterocyles containing indole nucleus, Dr. Prabhakar Chavan, he is the supervisor of the overall work. Dr. Jaishree B. and Dr. Prashant C Hanamshetty were involved in carrying out antioxidant activities.

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