• SATHIYA S Department of Chemistry, Vivekanandha College of Arts and Sciences for Women, Namakkal, Tamil Nadu, India.
  • KRISHNAMOORTHY BS Department of Chemistry (UA), PSG College of Arts and Science, Coimbatore, Tamil Nadu, India.
  • MEENACHI S Department of Chemistry, K. S. Rangasamy College of Technology, Namakkal, Tamil Nadu, India.
  • RAVIKUMAR R Department of Chemistry, Dr. N. G. P. Arts and Science College, Coimbatore, Tamil Nadu, India.



1,2,3-triazole, Chalcone, Pyrazoline, Anti-microbial activity , anti-oxidant activity.


Objectives: The present work planned to investigate the anti-bacterial, anti-fungal, and anti-oxidant activity against 4-amino benzamide derived 1,2,3-triazole linked chalcone and pyrazoline derivatives.

Methods: Anti-microbial activity for pyrazoline derivatives was accomplished by serial dilution method. The test organisms of bacterial strains were (Enterococcus faecalis, Staphylococcus aureus, Klebsiella pneumoniae, and Pseudomonas fluorescence) and the fungal cultures (Aspergillus niger, Aspergillus terreus, and Trichoderma harzanium). The method used in the anti-oxidant activity is 2,2-diphenyl-1-picrylhydrazyl (DPPH) and nitric oxide scavenging method.

Results: All the compounds showed good to moderate anti-bacterial and anti-fungal activities. The results of IC50 values showed lower potent inhibition activity with DPPH and higher potent inhibition activity in nitric oxide scavenging method.

Conclusion: All the compounds had exhibited capricious growth inhibitory effect on anti-bacterial, anti-fungal, and anti-oxidant activities.


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How to Cite

S, S., K. BS, M. S, and R. R. “BIOLOGICAL STUDIES OF 4-AMINO BENZAMIDE DERIVED 1,2,3-TRIAZOLE LINKED CHALCONE AND ITS PYRAZOLINE DERIVATIVES”. Asian Journal of Pharmaceutical and Clinical Research, vol. 15, no. 9, Sept. 2022, pp. 94-97, doi:10.22159/ajpcr.2022.v15i9.45089.



Original Article(s)