Anu Radha, Vilashene Ganasan, Lalithambigai Joobi, Arunkumar S



Cosmeceuticals are the latest addition to the health industry and are described as cosmetic products with drug-like activities. Cosmetics are products
that are used to cleanse and beautify the skin (Millikan, 2001). Pharmaceuticals are essentially drug products and are defined as products that prevent,
mitigate, treat or cure disease and/or affect the structure or function of the body (Vermeer and Gilchrest, 1996). Cosmeceuticals is a deliberate
portmanteau of these two terms and is intended to connote drug-like benefits from an otherwise cosmetic product. While the food, drug, and cosmetic
act does not recognize the term “cosmeceutical,” the cosmetic industry has begun to use this word to refer to cosmetic products that have drug-like
benefits. The term cosmeceutical was coined by Kilgman, but these lines of product became popular in 1996 and have an expanding market that has
rapidly reached Africa. Many scientists and health consumers in Africa may not be conversant with this line of products. They may, therefore, be underresearched
or over-utilized. In the cosmetic arena, many materials are used commercially. Cosmetic ingredients previously considered “inert” have
the potential to provide a biologic effect to the skin. In a cosmeceutical formulation, the boundary between an “active” and “inert” ingredient may be
obscured. There is most common names of the different ingredients used in cosmeceutical products such as antioxidants, the binding agent, emollients,
emulsions, humectants, lubricants, preservatives, solvents, surfactants, vehicle, etc. “Potential for cosmeceutical ingredients in the United States alone
is SI00 million and includes such products as skin peelers, wrinkle creams, emollients, hair growth stimulants, skin lighteners and darkeners, and
botanicals. The 75 million baby boomers are the major market for cosmeceuticals. Cosmeceuticals claims are largely unsubstantiated and the term,
though misleading, has probably come to stay. The term and the target consumers appear flamboyant enough to with stand Government regulations.
In a free trade world, the benefits and adverse effects of cosmeceuticals are probably optimized by frequent review to inform the clinical and public
stake-holders of their uses and limitations. This comprehensive review attempts to briefly, expand the recent knowledge about cosmeceuticals.
Keywords: Cosmetics, Formulation/stability, Safety testing, Claim substantiation.

| PDF |


Grace R. Cosmeceuticals: Functional food for the skin. Nat Foods Merchandiser 2002;XXIII:92-9.

Millikan LE. Cosmetology, cosmetics, cosmeceuticals: definitions and regulations. Clin Dermatol 2001;19(4):371-4.

Rona C, Vailati F, Berardesca E. The cosmetic treatment of wrinkles. J Cosmet Dermatol 2004;3(1):26-34.

Reed R. The definition of “cosmeceutical”. J Soc Cosmet Chem 1962;13:103-6.

Draelos ZD. New developments in cosmetics and skin care products. Adv Dermatol 1997;12:3-17.

Oricha BS. Cosmeceuticals: A review. Afr J Pharm Pharmacol 2010;4(4):127-9.

Mehta RC, Fitzpatrick RE. Endogenous growth factors as cosmeceuticals. Dermatol Ther 2007;20(5):350-9.

Dureja H, Kaushik D, Gupta M, Kumar V, Lather V. Cosmeceuticals: An emerging concept. Indian J Pharmacol 2005;37(3):155-9.

Dooley TP. Is there room for a moderate level of regulatory oversight? In: Hori W, editor. Drug Discovery Approaches for Developing Cosmeceuticals: Advanced Skin Care and Cosmetic Products. Southborough: IBC Library Series; 1997.

Newburger AE. Cosmeceuticals: myths and misconceptions. Clin Dermatol 2009;27:446-52.

Lupo MP, Cole AL. Cosmeceutical peptides. Dermatol Ther 2007;20(5):343-9.

Rattan SI. The science of healthy aging: genes, milieu, and chance. Ann N Y Acad Sci 2007;1114:1-10.

Baumann LS. Less-known botanical cosmeceuticals. Dermatol Ther 2007;20(5):330-42.

Burke KE. Interaction of vitamins C and E as better cosmeceuticals. Dermatol Ther 2007;20(5):314-21.

Chiu PC, Chan CC, Lin HM, Chiu HC. The clinical anti-aging effects of topical kinetin and niacinamide in Asians: a randomized, double-blind, placebo-controlled, split-face comparative trial. J Cosmet Dermatol 2007;6(4):243-9.

Balch PA, Balch JF. In: Prescription for Nutritional Healing. 3rd ed. Vonore: Avery Publishing Group; 2000.

Turkington CA, Dover JS. In: The Encyclopedia of Skin and Skin Disorders. 2nd ed. New York: Facts on File; 2002.

Duber SD. Natural cosmeceuticals. Driving personal care growth today and tomorrow. Neutraceuticals World 2003;6:58-60.

Teneralli MJ. Traditional skin care lines improving looks with dietary supplements. Neutraceuticals World 2004;7:74-80.

Tamm J. Cosmetics for treatment of hair and skin. US Patent 4272508, 1981.

Kuno N. Matsumoto, M., Skin-beautifying agent, anti-aging agent for the skin, whitening agent and external agent for the skin. US Patent 6682763, 2004.

Arquette DJ. Dry emollient composition composing mono-unsaturated jojoba esters. US Patent 6432428, 2002.

Martin R. Use of atleast one extract of the genus chrysanthemum for assisting skin and/or hair pigmentation. US Patent 6726940, 2004.

Smith WP. Barrier disruption treatments for structurally deteriorated skin. US Patent 5720963, 1998.

Holloway VL. Ethnic cosmetic products. Dermatol Clin 2003;21(4):743-9.

Govier WC. Sunscreen composition. US Patent 4900541, 1990.

Filomeno VG. Skin bleaching detergent bar. US Patent 4692261, 1987.

Filomeno VG. Skin bleaching preprations. US Patent 4792443, 1988.29. Trüeb RM. Swiss trichology study group. The value of hair cosmetics and pharmaceuticals. Dermatology 2001;202:275-82.

Grollier JF, Rosenbaum G. A cosmetic composition for the treatment of hair, in particular oily hair, based on extract of yarrow (Achillea millefolium L). US Patent 4948583, 1990.

Shin MS. Hair-care cosmetic compositions having dandruff formation suppression effect. US Patent 5886031, 1999.

Buck CJ. Method for treatment for androgenic alopecia. US Patent 5609858, 1997.

Mausner JJ. Protein shampoo. US Patent 4140759, 1979.

Shapiro J, Maddin S. Medicated shampoos. Clin Dermatol 1996;14:123-8.

Mahé YF, Buan B, Bernard BA. A minoxidil-related compound lacking a C6 substitution still exhibits strong anti-lysyl hydroxylase activity in vitro. Skin Pharmacol 1996;9:177-83.

Jaworsky C, Kligman AM, Murphy GF. Characterization of inflammatory infiltrates in male pattern alopecia, implications for pathogenesis. Br J Dermatol 1992;127:239-46.

Courtois M, Loussouarn G, Hourseau C, Grollier JF. Periodicity in the growth and shedding of hair. Br J Dermatol 1996;134:47-54.

Sawaya ME. Novel agents for the treatment of alopecia. Semin Cutan Med Surg 1998;17:276-83.

Lawlor TM. Dental care compositions. US Patent 6685921, 2004.

Kapoor VK, Dureja J, Chadha R. Herbals in the control of ageing. Drug Discov Today 2009;14(19-20):992-8.

Ravichandran G, Bharadwaj VS, Kolhapure SA. Evaluation of the efficacy and safety of Anti – Wrinkle cream in the treatment of facial skin wrinkles: A prospective, open, phase III clinical trial. Antiseptic 2005;102(2):65-70.

Sharangi AB. Medicinal and therapeutic potentialities of tea (Camellia sinensis L.) – A review. Food Res Int 2009;42:529-35.

Solovchenko A, Schmitz-Eiberger M. Significance of skin flavonoids for UV-B-protection in apple fruits. J Exp Bot 2003;54(389):1977-84.

Apak R, Guçlu K, Demirata B, Özyürek M, Çelik SE, Bektasoglu B, et al. Comparative evaluation of various total antioxidant capacity assays applied to phenolic compounds with the CUPRAC assay. Molecules 2007;12:1496-547.

Vertuani S, Ziosi P, Solaroli N, Buzzoni V, Carli M, Lucchi E, et al. Determination of antioxidant efficacy of cosmetic formulations by non-invasive measurements. Skin Res Technol 2003;9(3):245-53.

Spaniter AH, Shahidi F, Paraliment TH, Mussinan C, Ho C, Contis ET. Food flavors and chemistry – Advances of the new millanium. Cambridge, UK: Royal Society Chemistry; 2001. p. 567.

Pegg RB, Amarowicz R, Naczk M. Phenolic compounds in food and natural health product. Washington, US: American Chemical Society; 2005. p. 67.

Giada MD, Mancini-Filho J. Antioxidant capacity of the striped sunflower (Helianthus annuus L.) seed extracts evaluated by three in vitro methods. Int J Food Sci Nutr 2009;60(5):395-401.

Kumar S, Maheshwari KK, Singh V. Protective effects of Punica granatum seeds extract against aging and scopolamine induced cognitive impairments in mice. Afr J Tradit Complement Altern Med 2008;6:49-56.

Shalaby NM, Maghraby AS, el-Hagrassy AM. Effect of Daucus carota var. boissieri extracts on immune response of Schistosoma mansoni infected mice. Folia Microbiol (Praha) 1999;44(4):441-8.

Koksal E, Gulcin I. Antioxidant activity of cauliflower (Brassica oleracea L.). Turk J Agric 2008;32:65-78.

Kaleem M, Asif M, Ahmed QU, Bano B. Antidiabetic and antioxidant activity of Annona squamosa extract in streptozotocin-induced diabetic rats. Singapore Med J 2006;47(8):670-5.

Fonseca AM, Bizerra AM, Souza JS, Monte FJ, Oliveira MC, Mattos MC, et al. Constituents and antioxidant activity of two varieties of coconut water (Cocos nucifera L.). Braz J Pharmacogn 2009;19(1B):193-8.

Choi J, Byun D. Studies of anti-aging action of Garlic. Allium sativum L. (I). Comparative study of garlic and ginseng compounds on antiaging action. Korean Biochem J 1986;19(2):140-6.

Saxena S. Glycyrrhiza glabra-medicine over the millennium. Nat Prod Radic 2005;4(5):358-67.

Soon YY, Tan BK. Evaluation of the hypoglycemic and antioxidant activities of Morinda officinalis in streptozotocin-induced diabetic rats. Singapore Med J 2002;43:077-85.

Srividya AR, Yadev AK, Dhanbal SP. Antioxidant and antimicrobial activity of rhizome of Curcuma aromatica and Curcuma zeodaria. Arch Pharm Sci Res 2002;1(1):14-9.

Patil SM, Kadam VJ, Ghosh R. In vitro antioxidant activity of methanolic extract of stem bark of Gmelina arborea roxb. (Verbenaceae). Int J Pharm Tech Res 2009;1(4):1480-4.

Mahadevan S, Park Y. Multifaceted therapeutic benefits of Ginkgo biloba L.: chemistry, efficacy, safety, and uses. J Food Sci 2008;73(1):R14-9.

Thornfeldt CR. Cosmeceuticals: separating fact from voodoo science. Skinmed 2005;4:214-20.

Farris PK. Topical vitamin C: a useful agent for treating photoaging and other dermatologic conditions. Dermatol Surg 2005;31:814-7.

Glaser DA. Anti-aging products and cosmeceuticals. Fac Plast Surg Clin North Am 2004;12(3):363-72.

Carpenter CP. Mammalian toxicity of 1-Napthyl-NMethylcarbamte (Sevin Insecticide). Agric Food Chem 1961;9(1):30-9.

Haward PH. Handbook of Environmental Fate and Exposure Data for Organic Chemicals. Vol. III. Chelsea, MI, USA: Lewis Publishers; 1991. p. 28.

Choi CM, Berson DS. Cosmeceuticals. Semin Cutan Med Surg 2006;25(3):163-8.

Sorg O, Antille C, Kaya G, Saurat JH. Retinoids in cosmeceuticals. Dermatol Ther 2006;19(5):289-96.

About this article





Additional Links

Manuscript Submission


Asian Journal of Pharmaceutical and Clinical Research
Vol 8 Issue 2 (March - April) 2015 Page: 64-69

Print ISSN


Online ISSN


Authors & Affiliations

Anu Radha
Aimst University

Vilashene Ganasan

Lalithambigai Joobi

Arunkumar S

Article Tools

Email this article (Login required)
Email the author (Login required)


  • There are currently no refbacks.